Novel regulatory role of non-coding RNAs in ankylosing spondylitis
Ankylosing spondylitis (AS) is a type of arthritis that primarily affects the spine and involves disorders of the immune and skeletal systems. However, the exact pathogenesis of AS is not fully understood. Non-coding RNAs (ncRNAs), particularly, long non-coding RNAs (lncRNAs), circular RNAs (circRNA...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2023-02-01
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| Series: | Frontiers in Immunology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1131355/full |
| _version_ | 1797895437378650112 |
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| author | Yanyan Fang Yanyan Fang Yanyan Fang Jian Liu Jian Liu Jian Liu |
| author_facet | Yanyan Fang Yanyan Fang Yanyan Fang Jian Liu Jian Liu Jian Liu |
| author_sort | Yanyan Fang |
| collection | DOAJ |
| description | Ankylosing spondylitis (AS) is a type of arthritis that primarily affects the spine and involves disorders of the immune and skeletal systems. However, the exact pathogenesis of AS is not fully understood. Non-coding RNAs (ncRNAs), particularly, long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), and micro RNAs (miRNAs) and their interactions have been shown to influence many biological processes such as inflammatory responses, osteogenic differentiation and apoptosis, pyroptosis, and proliferation. In addition, ncRNAs reflect the disease activity of AS. In this review, we discuss the regulatory roles of ncRNAs in AS cell functions (inflammatory responses, cellular osteogenic differentiation and apoptosis, pyroptosis, and proliferation) and their potential applications in AS diagnosis and treatment. Understanding the role of ncRNAs in the pathogenesis of AS will lay the foundation for exploring potential new therapeutic approaches for AS. |
| first_indexed | 2024-04-10T07:26:50Z |
| format | Article |
| id | doaj.art-d7430fc044064a9d919a9503dd04f3b6 |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-04-10T07:26:50Z |
| publishDate | 2023-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-d7430fc044064a9d919a9503dd04f3b62023-02-24T06:32:10ZengFrontiers Media S.A.Frontiers in Immunology1664-32242023-02-011410.3389/fimmu.2023.11313551131355Novel regulatory role of non-coding RNAs in ankylosing spondylitisYanyan Fang0Yanyan Fang1Yanyan Fang2Jian Liu3Jian Liu4Jian Liu5The First Affiliated Hospital, Anhui University of Chinese Medicine, Hefei, ChinaKey Laboratory of Xin'an Medicine of the Ministry of Education, Anhui University of Chinese Medicine, Hefei, ChinaAnhui Province Key Laboratory of Modern Chinese Medicine Department of Internal Medicine Application Foundation Research and Development, Hefei, ChinaThe First Affiliated Hospital, Anhui University of Chinese Medicine, Hefei, ChinaAnhui Province Key Laboratory of Modern Chinese Medicine Department of Internal Medicine Application Foundation Research and Development, Hefei, ChinaInstitute of Rheumatology, Anhui Academy of Chinese Medicine, Hefei, ChinaAnkylosing spondylitis (AS) is a type of arthritis that primarily affects the spine and involves disorders of the immune and skeletal systems. However, the exact pathogenesis of AS is not fully understood. Non-coding RNAs (ncRNAs), particularly, long non-coding RNAs (lncRNAs), circular RNAs (circRNAs), and micro RNAs (miRNAs) and their interactions have been shown to influence many biological processes such as inflammatory responses, osteogenic differentiation and apoptosis, pyroptosis, and proliferation. In addition, ncRNAs reflect the disease activity of AS. In this review, we discuss the regulatory roles of ncRNAs in AS cell functions (inflammatory responses, cellular osteogenic differentiation and apoptosis, pyroptosis, and proliferation) and their potential applications in AS diagnosis and treatment. Understanding the role of ncRNAs in the pathogenesis of AS will lay the foundation for exploring potential new therapeutic approaches for AS.https://www.frontiersin.org/articles/10.3389/fimmu.2023.1131355/fulllncRNAscircRNAsmiRNAsceRNAankylosing spondylitis |
| spellingShingle | Yanyan Fang Yanyan Fang Yanyan Fang Jian Liu Jian Liu Jian Liu Novel regulatory role of non-coding RNAs in ankylosing spondylitis Frontiers in Immunology lncRNAs circRNAs miRNAs ceRNA ankylosing spondylitis |
| title | Novel regulatory role of non-coding RNAs in ankylosing spondylitis |
| title_full | Novel regulatory role of non-coding RNAs in ankylosing spondylitis |
| title_fullStr | Novel regulatory role of non-coding RNAs in ankylosing spondylitis |
| title_full_unstemmed | Novel regulatory role of non-coding RNAs in ankylosing spondylitis |
| title_short | Novel regulatory role of non-coding RNAs in ankylosing spondylitis |
| title_sort | novel regulatory role of non coding rnas in ankylosing spondylitis |
| topic | lncRNAs circRNAs miRNAs ceRNA ankylosing spondylitis |
| url | https://www.frontiersin.org/articles/10.3389/fimmu.2023.1131355/full |
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