Acquisition of Cisplatin Resistance Shifts Head and Neck Squamous Cell Carcinoma Metabolism toward Neutralization of Oxidative Stress

Acquisition of Cisplatin Resistance Shifts Head and Neck Squamous Cell Carcinoma Metabolism toward Neutralization of Oxidative Stress

<i>Background</i>: Cisplatin (CDDP) is commonly utilized in the treatment of advanced solid tumors including head and neck squamous cell carcinoma (HNSCC). Cisplatin response remains highly variable among individual tumors and development of cisplatin resistance is common. We hypothesize...

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Bibliographic Details
Main Authors: Wangjie Yu, Yunyun Chen, Nagireddy Putluri, Cristian Coarfa, Matthew J. Robertson, Vasanta Putluri, Fabio Stossi, Julien Dubrulle, Michael A. Mancini, Jonathan C. Pang, Trung Nguyen, Dodge Baluya, Jeffrey N. Myers, Stephen Y. Lai, Vlad C. Sandulache
Format: Article
Language:English
Published: MDPI AG 2020-06-01
Series:Cancers
Subjects:
cisplatin
head and neck cancer
fatty acid
ferroptosis
amino acid
oxidative stress
Online Access:https://www.mdpi.com/2072-6694/12/6/1670

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