The endoplasmic reticulum stress-autophagy pathway controls hypothalamic development and energy balance regulation in leptin-deficient neonates
Overnutrition is associated with hypothalamic ER stress and impaired leptin signaling. Here the authors show that ER stress already occurs in neonates and that treatment with the ER stress relieving drug TUDCA early in life has beneficial metabolic and neurodevelopmental effects.
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2020-04-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-020-15624-y |
| _version_ | 1819195148968394752 |
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| author | Soyoung Park Aleek Aintablian Berengere Coupe Sebastien G. Bouret |
| author_facet | Soyoung Park Aleek Aintablian Berengere Coupe Sebastien G. Bouret |
| author_sort | Soyoung Park |
| collection | DOAJ |
| description | Overnutrition is associated with hypothalamic ER stress and impaired leptin signaling. Here the authors show that ER stress already occurs in neonates and that treatment with the ER stress relieving drug TUDCA early in life has beneficial metabolic and neurodevelopmental effects. |
| first_indexed | 2024-12-23T02:08:10Z |
| format | Article |
| id | doaj.art-d74405cf600e446290944a2d17d97396 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-23T02:08:10Z |
| publishDate | 2020-04-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-d74405cf600e446290944a2d17d973962022-12-21T18:03:51ZengNature PortfolioNature Communications2041-17232020-04-0111111110.1038/s41467-020-15624-yThe endoplasmic reticulum stress-autophagy pathway controls hypothalamic development and energy balance regulation in leptin-deficient neonatesSoyoung Park0Aleek Aintablian1Berengere Coupe2Sebastien G. Bouret3The Saban Research Institute, Developmental Neuroscience Program, Children’s Hospital Los Angeles, University of Southern CaliforniaThe Saban Research Institute, Developmental Neuroscience Program, Children’s Hospital Los Angeles, University of Southern CaliforniaThe Saban Research Institute, Developmental Neuroscience Program, Children’s Hospital Los Angeles, University of Southern CaliforniaInserm, Laboratory of Development and Plasticity of the Neuroendocrine Brain, Jean-Pierre Aubert Research CentreOvernutrition is associated with hypothalamic ER stress and impaired leptin signaling. Here the authors show that ER stress already occurs in neonates and that treatment with the ER stress relieving drug TUDCA early in life has beneficial metabolic and neurodevelopmental effects.https://doi.org/10.1038/s41467-020-15624-y |
| spellingShingle | Soyoung Park Aleek Aintablian Berengere Coupe Sebastien G. Bouret The endoplasmic reticulum stress-autophagy pathway controls hypothalamic development and energy balance regulation in leptin-deficient neonates Nature Communications |
| title | The endoplasmic reticulum stress-autophagy pathway controls hypothalamic development and energy balance regulation in leptin-deficient neonates |
| title_full | The endoplasmic reticulum stress-autophagy pathway controls hypothalamic development and energy balance regulation in leptin-deficient neonates |
| title_fullStr | The endoplasmic reticulum stress-autophagy pathway controls hypothalamic development and energy balance regulation in leptin-deficient neonates |
| title_full_unstemmed | The endoplasmic reticulum stress-autophagy pathway controls hypothalamic development and energy balance regulation in leptin-deficient neonates |
| title_short | The endoplasmic reticulum stress-autophagy pathway controls hypothalamic development and energy balance regulation in leptin-deficient neonates |
| title_sort | endoplasmic reticulum stress autophagy pathway controls hypothalamic development and energy balance regulation in leptin deficient neonates |
| url | https://doi.org/10.1038/s41467-020-15624-y |
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