The predictive value of fibrinogen in the occurrence of mild cognitive impairment events in patients with diabetic peripheral neuropathy
Abstract Background Research suggests that fibrinogen (Fib) is related to mild cognitive impairment (MCI) and diabetic peripheral neuropathy (DPN) and the risk of MCI in patients with DPN is greatly increased, although no studies have evaluated the predictive value of Fib for the risk of MCI in pati...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-11-01
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| Series: | BMC Endocrine Disorders |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12902-022-01185-2 |
| _version_ | 1797984715085447168 |
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| author | Yong Zhuang Huibin Huang Zhenfei Fu Jinying Zhang Qingyan Cai |
| author_facet | Yong Zhuang Huibin Huang Zhenfei Fu Jinying Zhang Qingyan Cai |
| author_sort | Yong Zhuang |
| collection | DOAJ |
| description | Abstract Background Research suggests that fibrinogen (Fib) is related to mild cognitive impairment (MCI) and diabetic peripheral neuropathy (DPN) and the risk of MCI in patients with DPN is greatly increased, although no studies have evaluated the predictive value of Fib for the risk of MCI in patients with DPN. Methods This prospective observational clinical study enrolled 207 type 2 diabetes mellitus (T2DM) patients, who were divided into diabetes with no neuropathy (102 cases) and diabetes with neuropathy (105 cases) groups. Meanwhile, 90 healthy unrelated subjects were recruited as controls. The incidence of MCI in the DPN patients was followed up for 2 years. Divide patients in the DPN group into subgroups according to whether MCI occur, use multivariate logistic regression to analyze independent factors of MCIs in DPN patients within 2 years, and use ROC curve to analyze the predictive value of Fib for MCI in DPN patients. Results Fib levels were significantly higher in diabetic subjects with neuropathy compared with those without (P < 0.001). In further subgroup analysis of DPN patients who were divided according to the occurrence of MCI, baseline data of the MCI subgroup showed Fib levels were higher than that in the non-MCI group while education levels declined (P < 0.001). The education level and increased Fib levels were independent factors for the occurrence of MCI within 2 years after the onset of DPN (OR = 0.769, 95% CI: 0.605 ~ 0.968, P = 0.037; OR = 2.674, 95% CI: 1.094 ~ 3.168, P = 0.002). The ROC curve indicated that the predictive value of Fib was (AUC = 0.764, 95% CI: 0.671 ~ 0.842, P < 0.001). Conclusions Fib may function as a predictor for assessing the risk of MCI in DPN patients. |
| first_indexed | 2024-04-11T07:07:15Z |
| format | Article |
| id | doaj.art-d744b46c9bea41a8aad239e17197e32c |
| institution | Directory Open Access Journal |
| issn | 1472-6823 |
| language | English |
| last_indexed | 2024-04-11T07:07:15Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Endocrine Disorders |
| spelling | doaj.art-d744b46c9bea41a8aad239e17197e32c2022-12-22T04:38:22ZengBMCBMC Endocrine Disorders1472-68232022-11-012211710.1186/s12902-022-01185-2The predictive value of fibrinogen in the occurrence of mild cognitive impairment events in patients with diabetic peripheral neuropathyYong Zhuang0Huibin Huang1Zhenfei Fu2Jinying Zhang3Qingyan Cai4Department of Endocrinology, The Second Affiliated Hospital of Fujian Medical UniversityDepartment of Endocrinology, The Second Affiliated Hospital of Fujian Medical UniversityDepartment of Endocrinology, The Second Affiliated Hospital of Fujian Medical UniversityDepartment of Neurology, The Second Affiliated Hospital of Fujian Medical UniversityDepartment of Endocrinology, The Second Affiliated Hospital of Fujian Medical UniversityAbstract Background Research suggests that fibrinogen (Fib) is related to mild cognitive impairment (MCI) and diabetic peripheral neuropathy (DPN) and the risk of MCI in patients with DPN is greatly increased, although no studies have evaluated the predictive value of Fib for the risk of MCI in patients with DPN. Methods This prospective observational clinical study enrolled 207 type 2 diabetes mellitus (T2DM) patients, who were divided into diabetes with no neuropathy (102 cases) and diabetes with neuropathy (105 cases) groups. Meanwhile, 90 healthy unrelated subjects were recruited as controls. The incidence of MCI in the DPN patients was followed up for 2 years. Divide patients in the DPN group into subgroups according to whether MCI occur, use multivariate logistic regression to analyze independent factors of MCIs in DPN patients within 2 years, and use ROC curve to analyze the predictive value of Fib for MCI in DPN patients. Results Fib levels were significantly higher in diabetic subjects with neuropathy compared with those without (P < 0.001). In further subgroup analysis of DPN patients who were divided according to the occurrence of MCI, baseline data of the MCI subgroup showed Fib levels were higher than that in the non-MCI group while education levels declined (P < 0.001). The education level and increased Fib levels were independent factors for the occurrence of MCI within 2 years after the onset of DPN (OR = 0.769, 95% CI: 0.605 ~ 0.968, P = 0.037; OR = 2.674, 95% CI: 1.094 ~ 3.168, P = 0.002). The ROC curve indicated that the predictive value of Fib was (AUC = 0.764, 95% CI: 0.671 ~ 0.842, P < 0.001). Conclusions Fib may function as a predictor for assessing the risk of MCI in DPN patients.https://doi.org/10.1186/s12902-022-01185-2Diabetic peripheral neuropathyMild cognitive impairment eventsFibrinogenPredictive value |
| spellingShingle | Yong Zhuang Huibin Huang Zhenfei Fu Jinying Zhang Qingyan Cai The predictive value of fibrinogen in the occurrence of mild cognitive impairment events in patients with diabetic peripheral neuropathy BMC Endocrine Disorders Diabetic peripheral neuropathy Mild cognitive impairment events Fibrinogen Predictive value |
| title | The predictive value of fibrinogen in the occurrence of mild cognitive impairment events in patients with diabetic peripheral neuropathy |
| title_full | The predictive value of fibrinogen in the occurrence of mild cognitive impairment events in patients with diabetic peripheral neuropathy |
| title_fullStr | The predictive value of fibrinogen in the occurrence of mild cognitive impairment events in patients with diabetic peripheral neuropathy |
| title_full_unstemmed | The predictive value of fibrinogen in the occurrence of mild cognitive impairment events in patients with diabetic peripheral neuropathy |
| title_short | The predictive value of fibrinogen in the occurrence of mild cognitive impairment events in patients with diabetic peripheral neuropathy |
| title_sort | predictive value of fibrinogen in the occurrence of mild cognitive impairment events in patients with diabetic peripheral neuropathy |
| topic | Diabetic peripheral neuropathy Mild cognitive impairment events Fibrinogen Predictive value |
| url | https://doi.org/10.1186/s12902-022-01185-2 |
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