Value of P300 amplitude in the diagnosis of untreated first-episode schizophrenia and psychosis risk syndrome in children and adolescents
Abstract Background Identifying the characteristic neurobiological changes of early psychosis is helpful for early clinical diagnosis. However, previous studies on the brain electrophysiology of children and adolescents with psychosis are rare. Methods This study compared P300 amplitude at multiple...
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| Format: | Article |
| Language: | English |
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BMC
2023-10-01
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| Series: | BMC Psychiatry |
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| Online Access: | https://doi.org/10.1186/s12888-023-05218-5 |
| _version_ | 1797451853606158336 |
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| author | Yaru Zhang Tingyu Yang Yuqiong He Fanchao Meng Kun Zhang Xingyue Jin Xilong Cui Xuerong Luo |
| author_facet | Yaru Zhang Tingyu Yang Yuqiong He Fanchao Meng Kun Zhang Xingyue Jin Xilong Cui Xuerong Luo |
| author_sort | Yaru Zhang |
| collection | DOAJ |
| description | Abstract Background Identifying the characteristic neurobiological changes of early psychosis is helpful for early clinical diagnosis. However, previous studies on the brain electrophysiology of children and adolescents with psychosis are rare. Methods This study compared P300 amplitude at multiple electrodes between children and adolescents with first-episode schizophrenia (FES, n = 48), children and adolescents with psychosis risk syndrome (PRS, n = 24), and healthy controls (HC, n = 30). Receiver operating characteristic (ROC) analysis was used to test the ability of P300 amplitude to distinguish FES, PRS and HC individuals. Results The P300 amplitude in the FES group were significantly lower than those in the HC at the Cz, Pz, and Oz electrodes. The P300 amplitude was also significantly lower in the prodromal group than in the HC at the Pz and Oz electrodes. ROC curve analysis showed that at the Pz electrode, the P300 amplitude evoked by the target and standard stimulus showed high sensitivity, specificity, accuracy, and area under the curve value for distinguishing FES from HC individuals. Conclusions This study found early visual P300 deficits in children and adolescents with FES and PRS, with the exclusion of possible influence of medication and chronic medical conditions, suggesting the value of P300 amplitude for the identification of early psychosis. |
| first_indexed | 2024-03-09T15:00:21Z |
| format | Article |
| id | doaj.art-d745dd6e909f43899ca5c455d35f9241 |
| institution | Directory Open Access Journal |
| issn | 1471-244X |
| language | English |
| last_indexed | 2024-03-09T15:00:21Z |
| publishDate | 2023-10-01 |
| publisher | BMC |
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| series | BMC Psychiatry |
| spelling | doaj.art-d745dd6e909f43899ca5c455d35f92412023-11-26T13:56:31ZengBMCBMC Psychiatry1471-244X2023-10-0123111010.1186/s12888-023-05218-5Value of P300 amplitude in the diagnosis of untreated first-episode schizophrenia and psychosis risk syndrome in children and adolescentsYaru Zhang0Tingyu Yang1Yuqiong He2Fanchao Meng3Kun Zhang4Xingyue Jin5Xilong Cui6Xuerong Luo7Department of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South UniversityDepartment of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South UniversityDepartment of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South UniversityThe National Clinical Research Center for Mental Disorders & Beijing Key Laboratory of Mental Disorders, Beijing Anding Hospital, Capital Medical UniversityDepartment of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South UniversityDepartment of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South UniversityDepartment of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South UniversityDepartment of Psychiatry, and National Clinical Research Center for Mental Disorders, The Second Xiangya Hospital of Central South UniversityAbstract Background Identifying the characteristic neurobiological changes of early psychosis is helpful for early clinical diagnosis. However, previous studies on the brain electrophysiology of children and adolescents with psychosis are rare. Methods This study compared P300 amplitude at multiple electrodes between children and adolescents with first-episode schizophrenia (FES, n = 48), children and adolescents with psychosis risk syndrome (PRS, n = 24), and healthy controls (HC, n = 30). Receiver operating characteristic (ROC) analysis was used to test the ability of P300 amplitude to distinguish FES, PRS and HC individuals. Results The P300 amplitude in the FES group were significantly lower than those in the HC at the Cz, Pz, and Oz electrodes. The P300 amplitude was also significantly lower in the prodromal group than in the HC at the Pz and Oz electrodes. ROC curve analysis showed that at the Pz electrode, the P300 amplitude evoked by the target and standard stimulus showed high sensitivity, specificity, accuracy, and area under the curve value for distinguishing FES from HC individuals. Conclusions This study found early visual P300 deficits in children and adolescents with FES and PRS, with the exclusion of possible influence of medication and chronic medical conditions, suggesting the value of P300 amplitude for the identification of early psychosis.https://doi.org/10.1186/s12888-023-05218-5AdolescentsChildrenFirst-episode schizophreniaP300Psychosis risk syndrome |
| spellingShingle | Yaru Zhang Tingyu Yang Yuqiong He Fanchao Meng Kun Zhang Xingyue Jin Xilong Cui Xuerong Luo Value of P300 amplitude in the diagnosis of untreated first-episode schizophrenia and psychosis risk syndrome in children and adolescents BMC Psychiatry Adolescents Children First-episode schizophrenia P300 Psychosis risk syndrome |
| title | Value of P300 amplitude in the diagnosis of untreated first-episode schizophrenia and psychosis risk syndrome in children and adolescents |
| title_full | Value of P300 amplitude in the diagnosis of untreated first-episode schizophrenia and psychosis risk syndrome in children and adolescents |
| title_fullStr | Value of P300 amplitude in the diagnosis of untreated first-episode schizophrenia and psychosis risk syndrome in children and adolescents |
| title_full_unstemmed | Value of P300 amplitude in the diagnosis of untreated first-episode schizophrenia and psychosis risk syndrome in children and adolescents |
| title_short | Value of P300 amplitude in the diagnosis of untreated first-episode schizophrenia and psychosis risk syndrome in children and adolescents |
| title_sort | value of p300 amplitude in the diagnosis of untreated first episode schizophrenia and psychosis risk syndrome in children and adolescents |
| topic | Adolescents Children First-episode schizophrenia P300 Psychosis risk syndrome |
| url | https://doi.org/10.1186/s12888-023-05218-5 |
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