Comparative effects of ethanol leaf and stem bark extracts of Irvingia gabonensis (BUSH MANGO) on sodium arsenite-induced lipid profile perturbtions in wistar rats
Abstract Background Exposure to arsenic orchestrates a myriad of noxious health effects, including cancer. Different parts of Irvingia gabonensis are used as herbal remedies in traditional medicine. In this study, the comparative effects of the ethanol leaf (ELEIG) and stem bark extracts (ESEIG) of...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
SpringerOpen
2021-01-01
|
| Series: | Clinical Phytoscience |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s40816-020-00241-5 |
| _version_ | 1818727000353800192 |
|---|---|
| author | Efosa Godwin Ewere Ngozi Paulinus Okolie Erhunmwunsee Dalton Avan Patience Edet Umoh |
| author_facet | Efosa Godwin Ewere Ngozi Paulinus Okolie Erhunmwunsee Dalton Avan Patience Edet Umoh |
| author_sort | Efosa Godwin Ewere |
| collection | DOAJ |
| description | Abstract Background Exposure to arsenic orchestrates a myriad of noxious health effects, including cancer. Different parts of Irvingia gabonensis are used as herbal remedies in traditional medicine. In this study, the comparative effects of the ethanol leaf (ELEIG) and stem bark extracts (ESEIG) of Irvingia gabonensis on sodium arsenite (SA)-induced lipid profile disturbances in Wistar rats were investigated. Methods Fifty five Wistar rats weighing between 100 g and 179 g were distributed into eleven groups (n=5). Group 1 (control) received feed and water ad libitum. Group 2 received SA at a dose of 4.1 mg/kg body weight (kgbw) for 14 days. Groups 3–11 were treated with the extracts with or without SA. Treatment was done by oral intubation for 14 days. Serum concentrations of total cholesterol (TC), triacylglycerol (TAG), high density lipoprotein cholesterol (HDL-c), low density lipoprotein cholesterol (LDL-c), very low density lipoprotein cholesterol (VLDL-c), total lipids (TL) and atherogenic index of plasma (AIP) were used to determine the lipid profile effects of the extracts. Results Exposure to SA caused significant (p ˂ 0.05) increases in all assayed parameters, relative to control. Post-treatment and simultaneous treatment with ELEIG and ESEIG mitigated the effects of SA. In addition, ELEIG alone at various doses produced results comparable with control values. However, ESEIG alone caused significant (p ˂ 0.05) increases in all assayed parameters, relative to control. Conclusion These results show that ELEIG and ESEIG ameliorate SA-induced lipid profile disturbances in Wistar rats. However, long-term administration of ESEIG alone may be discouraged. |
| first_indexed | 2024-12-17T22:07:08Z |
| format | Article |
| id | doaj.art-d746154ae9ce494486b3c48dcb46ef69 |
| institution | Directory Open Access Journal |
| issn | 2199-1197 |
| language | English |
| last_indexed | 2024-12-17T22:07:08Z |
| publishDate | 2021-01-01 |
| publisher | SpringerOpen |
| record_format | Article |
| series | Clinical Phytoscience |
| spelling | doaj.art-d746154ae9ce494486b3c48dcb46ef692022-12-21T21:30:50ZengSpringerOpenClinical Phytoscience2199-11972021-01-01711710.1186/s40816-020-00241-5Comparative effects of ethanol leaf and stem bark extracts of Irvingia gabonensis (BUSH MANGO) on sodium arsenite-induced lipid profile perturbtions in wistar ratsEfosa Godwin Ewere0Ngozi Paulinus Okolie1Erhunmwunsee Dalton Avan2Patience Edet Umoh3Biochemistry Department, University of BeninBiochemistry Department, University of BeninBiochemistry Department, University of BeninBiochemistry Department, University of UyoAbstract Background Exposure to arsenic orchestrates a myriad of noxious health effects, including cancer. Different parts of Irvingia gabonensis are used as herbal remedies in traditional medicine. In this study, the comparative effects of the ethanol leaf (ELEIG) and stem bark extracts (ESEIG) of Irvingia gabonensis on sodium arsenite (SA)-induced lipid profile disturbances in Wistar rats were investigated. Methods Fifty five Wistar rats weighing between 100 g and 179 g were distributed into eleven groups (n=5). Group 1 (control) received feed and water ad libitum. Group 2 received SA at a dose of 4.1 mg/kg body weight (kgbw) for 14 days. Groups 3–11 were treated with the extracts with or without SA. Treatment was done by oral intubation for 14 days. Serum concentrations of total cholesterol (TC), triacylglycerol (TAG), high density lipoprotein cholesterol (HDL-c), low density lipoprotein cholesterol (LDL-c), very low density lipoprotein cholesterol (VLDL-c), total lipids (TL) and atherogenic index of plasma (AIP) were used to determine the lipid profile effects of the extracts. Results Exposure to SA caused significant (p ˂ 0.05) increases in all assayed parameters, relative to control. Post-treatment and simultaneous treatment with ELEIG and ESEIG mitigated the effects of SA. In addition, ELEIG alone at various doses produced results comparable with control values. However, ESEIG alone caused significant (p ˂ 0.05) increases in all assayed parameters, relative to control. Conclusion These results show that ELEIG and ESEIG ameliorate SA-induced lipid profile disturbances in Wistar rats. However, long-term administration of ESEIG alone may be discouraged.https://doi.org/10.1186/s40816-020-00241-5Irvingia gabonensisSodium arseniteLipid profileCholesterolArsenicEnvironmental pollutant |
| spellingShingle | Efosa Godwin Ewere Ngozi Paulinus Okolie Erhunmwunsee Dalton Avan Patience Edet Umoh Comparative effects of ethanol leaf and stem bark extracts of Irvingia gabonensis (BUSH MANGO) on sodium arsenite-induced lipid profile perturbtions in wistar rats Clinical Phytoscience Irvingia gabonensis Sodium arsenite Lipid profile Cholesterol Arsenic Environmental pollutant |
| title | Comparative effects of ethanol leaf and stem bark extracts of Irvingia gabonensis (BUSH MANGO) on sodium arsenite-induced lipid profile perturbtions in wistar rats |
| title_full | Comparative effects of ethanol leaf and stem bark extracts of Irvingia gabonensis (BUSH MANGO) on sodium arsenite-induced lipid profile perturbtions in wistar rats |
| title_fullStr | Comparative effects of ethanol leaf and stem bark extracts of Irvingia gabonensis (BUSH MANGO) on sodium arsenite-induced lipid profile perturbtions in wistar rats |
| title_full_unstemmed | Comparative effects of ethanol leaf and stem bark extracts of Irvingia gabonensis (BUSH MANGO) on sodium arsenite-induced lipid profile perturbtions in wistar rats |
| title_short | Comparative effects of ethanol leaf and stem bark extracts of Irvingia gabonensis (BUSH MANGO) on sodium arsenite-induced lipid profile perturbtions in wistar rats |
| title_sort | comparative effects of ethanol leaf and stem bark extracts of irvingia gabonensis bush mango on sodium arsenite induced lipid profile perturbtions in wistar rats |
| topic | Irvingia gabonensis Sodium arsenite Lipid profile Cholesterol Arsenic Environmental pollutant |
| url | https://doi.org/10.1186/s40816-020-00241-5 |
| work_keys_str_mv | AT efosagodwinewere comparativeeffectsofethanolleafandstembarkextractsofirvingiagabonensisbushmangoonsodiumarseniteinducedlipidprofileperturbtionsinwistarrats AT ngozipaulinusokolie comparativeeffectsofethanolleafandstembarkextractsofirvingiagabonensisbushmangoonsodiumarseniteinducedlipidprofileperturbtionsinwistarrats AT erhunmwunseedaltonavan comparativeeffectsofethanolleafandstembarkextractsofirvingiagabonensisbushmangoonsodiumarseniteinducedlipidprofileperturbtionsinwistarrats AT patienceedetumoh comparativeeffectsofethanolleafandstembarkextractsofirvingiagabonensisbushmangoonsodiumarseniteinducedlipidprofileperturbtionsinwistarrats |