Optimization of an Antibody Light Chain Framework Enhances Expression, Biophysical Properties and Pharmacokinetics

Optimization of an Antibody Light Chain Framework Enhances Expression, Biophysical Properties and Pharmacokinetics

Efficacy, safety, and manufacturability of therapeutic antibodies are influenced by their biopharmaceutical and biophysical properties. These properties can be optimized by library approaches or rationale protein design. Here, we employed a protein engineering approach to modify the variable domain...

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Bibliographic Details
Main Authors: Patrice Douillard, Michael Freissmuth, Gerhard Antoine, Michael Thiele, Daniel Fleischanderl, Peter Matthiessen, Dirk Voelkel, Randolf J. Kerschbaumer, Friedrich Scheiflinger, Nicolas Sabarth
Format: Article
Language:English
Published: MDPI AG 2019-09-01
Series:Antibodies
Subjects:
antibody engineering
thermal stability
antibody expression
pharmacokinetics
framework
germline
MIF
aggregation
Online Access:https://www.mdpi.com/2073-4468/8/3/46

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