Antithrombotic therapy in patients with non-traumatic intracerebral haemorrhage and atrial fibrillation: A retrospective study
Introduction: The aim of the study was to determine the outcome, prescribed therapy, and localization of non-traumatic intracerebral haemorrhage in patients with atrial fibrillation. Patients and methods: This retrospective study enrolled patients with atrial fibrillation hospitalised for non-trauma...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-01-01
|
| Series: | Heliyon |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844020300645 |
| _version_ | 1828889201168351232 |
|---|---|
| author | Hrvoje Budinčević Petra Črnac Žuna Christian Saleh Nicholas Lange Bartlomiej Piechowski-Jozwiak Ivan Bielen Vida Demarin |
| author_facet | Hrvoje Budinčević Petra Črnac Žuna Christian Saleh Nicholas Lange Bartlomiej Piechowski-Jozwiak Ivan Bielen Vida Demarin |
| author_sort | Hrvoje Budinčević |
| collection | DOAJ |
| description | Introduction: The aim of the study was to determine the outcome, prescribed therapy, and localization of non-traumatic intracerebral haemorrhage in patients with atrial fibrillation. Patients and methods: This retrospective study enrolled patients with atrial fibrillation hospitalised for non-traumatic intracerebral haemorrhage from 2004 to 2013. We compared the patients according to previous antithrombotic therapy, demographics, previous CHADS2 score, comorbidities, the international normalised ration, localisation of intracerebral hamorrhage, stroke severity, prescribed antithrombotic therapy and outcome. Results: A total of 85 patients were enrolled and assigned to an AT+ group (n = 49; 14 on aspirin, 35 on warfarin) and an AT- group (n = 36; without antithrombotic therapy prior to hospitalisation). The latter had a lower proportion of known atrial fibrillation (90% vs 47%, P < 0.001). The mean INR was 2.6 ± 1.5. The in-hospital mortality rates in both groups were high: 43% in AT+ group and 47% in AT- group. There were no significant differences in any of the predefined comparisons. Conclusion: Treating patients with intracerebral haemorrhage and atrial fibrillation is challenging due to higher mortality rates and issues regarding the use of antithrombotic treatment in stroke prevention. Based on our data, prior antithrombotic therapy was not associated with increased in-hospital mortality rates or poorer functional outcome at hospital discharge in comparison with no prior antithrombotic therapy. |
| first_indexed | 2024-12-13T12:36:35Z |
| format | Article |
| id | doaj.art-d748450bae8b4a68af5892885f434735 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-12-13T12:36:35Z |
| publishDate | 2020-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-d748450bae8b4a68af5892885f4347352022-12-21T23:45:49ZengElsevierHeliyon2405-84402020-01-0161e03219Antithrombotic therapy in patients with non-traumatic intracerebral haemorrhage and atrial fibrillation: A retrospective studyHrvoje Budinčević0Petra Črnac Žuna1Christian Saleh2Nicholas Lange3Bartlomiej Piechowski-Jozwiak4Ivan Bielen5Vida Demarin6Stroke and Intensive Care Unit, Department of Neurology, Sveti Duh University Hospital, Zagreb, Croatia; School of Medicine, University J. J. Strossmayer, Osijek, Croatia; Corresponding author.Stroke and Intensive Care Unit, Department of Neurology, Sveti Duh University Hospital, Zagreb, CroatiaDepartment of Neurology, Centre Hospitalier de Luxembourg, Luxembourg, LuxembourgDepartment of Psychiatry, Harvard Medical School, Boston, MA, USADepartment of Neurology, King's College Hospital NHS Foundation Trust, London, United KingdomStroke and Intensive Care Unit, Department of Neurology, Sveti Duh University Hospital, Zagreb, Croatia; School of Medicine, University J. J. Strossmayer, Osijek, CroatiaInternational Institute for Brain Health, Zagreb, CroatiaIntroduction: The aim of the study was to determine the outcome, prescribed therapy, and localization of non-traumatic intracerebral haemorrhage in patients with atrial fibrillation. Patients and methods: This retrospective study enrolled patients with atrial fibrillation hospitalised for non-traumatic intracerebral haemorrhage from 2004 to 2013. We compared the patients according to previous antithrombotic therapy, demographics, previous CHADS2 score, comorbidities, the international normalised ration, localisation of intracerebral hamorrhage, stroke severity, prescribed antithrombotic therapy and outcome. Results: A total of 85 patients were enrolled and assigned to an AT+ group (n = 49; 14 on aspirin, 35 on warfarin) and an AT- group (n = 36; without antithrombotic therapy prior to hospitalisation). The latter had a lower proportion of known atrial fibrillation (90% vs 47%, P < 0.001). The mean INR was 2.6 ± 1.5. The in-hospital mortality rates in both groups were high: 43% in AT+ group and 47% in AT- group. There were no significant differences in any of the predefined comparisons. Conclusion: Treating patients with intracerebral haemorrhage and atrial fibrillation is challenging due to higher mortality rates and issues regarding the use of antithrombotic treatment in stroke prevention. Based on our data, prior antithrombotic therapy was not associated with increased in-hospital mortality rates or poorer functional outcome at hospital discharge in comparison with no prior antithrombotic therapy.http://www.sciencedirect.com/science/article/pii/S2405844020300645CardiologyClinical researchEmergency medicineNeurologyPharmacologyIntracerebral haemorrhage |
| spellingShingle | Hrvoje Budinčević Petra Črnac Žuna Christian Saleh Nicholas Lange Bartlomiej Piechowski-Jozwiak Ivan Bielen Vida Demarin Antithrombotic therapy in patients with non-traumatic intracerebral haemorrhage and atrial fibrillation: A retrospective study Heliyon Cardiology Clinical research Emergency medicine Neurology Pharmacology Intracerebral haemorrhage |
| title | Antithrombotic therapy in patients with non-traumatic intracerebral haemorrhage and atrial fibrillation: A retrospective study |
| title_full | Antithrombotic therapy in patients with non-traumatic intracerebral haemorrhage and atrial fibrillation: A retrospective study |
| title_fullStr | Antithrombotic therapy in patients with non-traumatic intracerebral haemorrhage and atrial fibrillation: A retrospective study |
| title_full_unstemmed | Antithrombotic therapy in patients with non-traumatic intracerebral haemorrhage and atrial fibrillation: A retrospective study |
| title_short | Antithrombotic therapy in patients with non-traumatic intracerebral haemorrhage and atrial fibrillation: A retrospective study |
| title_sort | antithrombotic therapy in patients with non traumatic intracerebral haemorrhage and atrial fibrillation a retrospective study |
| topic | Cardiology Clinical research Emergency medicine Neurology Pharmacology Intracerebral haemorrhage |
| url | http://www.sciencedirect.com/science/article/pii/S2405844020300645 |
| work_keys_str_mv | AT hrvojebudincevic antithrombotictherapyinpatientswithnontraumaticintracerebralhaemorrhageandatrialfibrillationaretrospectivestudy AT petracrnaczuna antithrombotictherapyinpatientswithnontraumaticintracerebralhaemorrhageandatrialfibrillationaretrospectivestudy AT christiansaleh antithrombotictherapyinpatientswithnontraumaticintracerebralhaemorrhageandatrialfibrillationaretrospectivestudy AT nicholaslange antithrombotictherapyinpatientswithnontraumaticintracerebralhaemorrhageandatrialfibrillationaretrospectivestudy AT bartlomiejpiechowskijozwiak antithrombotictherapyinpatientswithnontraumaticintracerebralhaemorrhageandatrialfibrillationaretrospectivestudy AT ivanbielen antithrombotictherapyinpatientswithnontraumaticintracerebralhaemorrhageandatrialfibrillationaretrospectivestudy AT vidademarin antithrombotictherapyinpatientswithnontraumaticintracerebralhaemorrhageandatrialfibrillationaretrospectivestudy |