Prevalence and predictors of dyslipidemia among HAART treated and HAART naive HIV positive clients attending Debre Tabor Hospital, Debre Tabor, Ethiopia
Background: Highly active anti-retroviral therapy has been reported to be associated with a number of side effects in human immunodeficiency virus patients among which dyslipidemia isa common metabolic disorder. Methods: A Hospital based comparative cross-sectional study among 228 HIV positive patie...
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| Format: | Article |
| Language: | English |
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Elsevier
2022-11-01
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| Series: | Heliyon |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2405844022026305 |
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| author | Anemut Tilahun Endeshaw Chekol Awgchew Behaile Teklemaryam Melaku Mekonnen Agidew Zelalem Tilahun Fitalew Tadele Admassu Nega Dagnaw Misganaw Asmamaw Mengstie Alebachew Amsalu Enyew Fenta Mengistu Yibeltal Akelew Tadesse Asmamaw Berihun Bantie |
| author_facet | Anemut Tilahun Endeshaw Chekol Awgchew Behaile Teklemaryam Melaku Mekonnen Agidew Zelalem Tilahun Fitalew Tadele Admassu Nega Dagnaw Misganaw Asmamaw Mengstie Alebachew Amsalu Enyew Fenta Mengistu Yibeltal Akelew Tadesse Asmamaw Berihun Bantie |
| author_sort | Anemut Tilahun |
| collection | DOAJ |
| description | Background: Highly active anti-retroviral therapy has been reported to be associated with a number of side effects in human immunodeficiency virus patients among which dyslipidemia isa common metabolic disorder. Methods: A Hospital based comparative cross-sectional study among 228 HIV positive patients was conducted from July to August 2020. Socio-demographic and clinical data were collected using structured questionnaires. Fasting venous blood sample was collected and analyzed for Lipid profiles. EDTA sample was analyzed for CD4+ T cell determination. Anthropometric measurement was done. Data were analyzed using SPSS version 22. Independent t-test was done. Logistic and binary regression was done. Result: A total of 228 HIV patients were enrolled in the study. Prevalence of dyslipidemia in HAART naive and HAART treated patients was 61 (53.5%) and 84 (73.7%), respectively. The prevalence of Total Cholesterol ≥200 mg/dl was 50% and 30%; High density lipoprotein cholesterol <40 mg/dl was 43.8% and 36%; Low density lipoprotein cholesterol ≥130 mg/dl was 48.3% and 28.1%; and Triglyceride ≥ 150 mg/dl 59.6% and 39% among HAART treated and HAART naive, respectively. Age greater than 40 years (AOR = 3.27, 95% C.I: 1.47–7.25), blood pressure ≥140/90 (AOR = 16.13, 95% C.I: 5.81–44.75), being on HAART (AOR = 2.73, 95% C.I: 1.35–5.53) and body mass index >25 kg/m2 (AOR = 1.92, 95% C.I: 1.20–4.81) were identified as determinants of dyslipidemia. Conclusion: The mean value of lipid profile was significantly higher among HAART treated as compared to those HAART naive HIV positive clients. |
| first_indexed | 2024-04-11T15:18:34Z |
| format | Article |
| id | doaj.art-d7490ffc3206436baadf94d867f34118 |
| institution | Directory Open Access Journal |
| issn | 2405-8440 |
| language | English |
| last_indexed | 2024-04-11T15:18:34Z |
| publishDate | 2022-11-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Heliyon |
| spelling | doaj.art-d7490ffc3206436baadf94d867f341182022-12-22T04:16:26ZengElsevierHeliyon2405-84402022-11-01811e11342Prevalence and predictors of dyslipidemia among HAART treated and HAART naive HIV positive clients attending Debre Tabor Hospital, Debre Tabor, EthiopiaAnemut Tilahun0Endeshaw Chekol1Awgchew Behaile Teklemaryam2Melaku Mekonnen Agidew3Zelalem Tilahun4Fitalew Tadele Admassu5Nega Dagnaw6Misganaw Asmamaw Mengstie7Alebachew Amsalu8Enyew Fenta Mengistu9Yibeltal Akelew10Tadesse Asmamaw11Berihun Bantie12Department of Biomedical Sciences, College of Health Sciences, Debre Tabor University, Debre Tabor, Ethiopia; Corresponding author.Department of Biomedical Sciences, College of Health Sciences, Debre Tabor University, Debre Tabor, EthiopiaDepartment of Biomedical Sciences, College of Health Sciences, Debre Tabor University, Debre Tabor, EthiopiaDepartment of Biomedical Sciences, College of Health Sciences, Debre Tabor University, Debre Tabor, EthiopiaDepartment of Biomedical Sciences, College of Health Sciences, Debre Tabor University, Debre Tabor, EthiopiaDepartment of Biomedical Sciences, College of Health Sciences, Debre Tabor University, Debre Tabor, EthiopiaDepartment of Biomedical Sciences, College of Health Sciences, Debre Tabor University, Debre Tabor, EthiopiaDepartment of Biomedical Sciences, College of Health Sciences, Debre Tabor University, Debre Tabor, EthiopiaDepartment of Public Health, College of Health Sciences, Debre Tabor University, Debre Tabor, EthiopiaDepartment of Biomedical Sciences, College of Health Sciences, Debre Markos University, Debre Markos, EthiopiaDepartment of Medical Laboratory, College of Health Sciences, Debre Markos University, Debre Markos, EthiopiaDepartment of Biochemistry, College of Health Sciences, Gondar University, Gondar, EthiopiaDepartment of Adult Health Nursing, College of Health Sciences, Debre Tabor University, Debre Tabor, EthiopiaBackground: Highly active anti-retroviral therapy has been reported to be associated with a number of side effects in human immunodeficiency virus patients among which dyslipidemia isa common metabolic disorder. Methods: A Hospital based comparative cross-sectional study among 228 HIV positive patients was conducted from July to August 2020. Socio-demographic and clinical data were collected using structured questionnaires. Fasting venous blood sample was collected and analyzed for Lipid profiles. EDTA sample was analyzed for CD4+ T cell determination. Anthropometric measurement was done. Data were analyzed using SPSS version 22. Independent t-test was done. Logistic and binary regression was done. Result: A total of 228 HIV patients were enrolled in the study. Prevalence of dyslipidemia in HAART naive and HAART treated patients was 61 (53.5%) and 84 (73.7%), respectively. The prevalence of Total Cholesterol ≥200 mg/dl was 50% and 30%; High density lipoprotein cholesterol <40 mg/dl was 43.8% and 36%; Low density lipoprotein cholesterol ≥130 mg/dl was 48.3% and 28.1%; and Triglyceride ≥ 150 mg/dl 59.6% and 39% among HAART treated and HAART naive, respectively. Age greater than 40 years (AOR = 3.27, 95% C.I: 1.47–7.25), blood pressure ≥140/90 (AOR = 16.13, 95% C.I: 5.81–44.75), being on HAART (AOR = 2.73, 95% C.I: 1.35–5.53) and body mass index >25 kg/m2 (AOR = 1.92, 95% C.I: 1.20–4.81) were identified as determinants of dyslipidemia. Conclusion: The mean value of lipid profile was significantly higher among HAART treated as compared to those HAART naive HIV positive clients.http://www.sciencedirect.com/science/article/pii/S2405844022026305DyslipidemiaHAARTHIV/AIDSDebre TaborEthiopia |
| spellingShingle | Anemut Tilahun Endeshaw Chekol Awgchew Behaile Teklemaryam Melaku Mekonnen Agidew Zelalem Tilahun Fitalew Tadele Admassu Nega Dagnaw Misganaw Asmamaw Mengstie Alebachew Amsalu Enyew Fenta Mengistu Yibeltal Akelew Tadesse Asmamaw Berihun Bantie Prevalence and predictors of dyslipidemia among HAART treated and HAART naive HIV positive clients attending Debre Tabor Hospital, Debre Tabor, Ethiopia Heliyon Dyslipidemia HAART HIV/AIDS Debre Tabor Ethiopia |
| title | Prevalence and predictors of dyslipidemia among HAART treated and HAART naive HIV positive clients attending Debre Tabor Hospital, Debre Tabor, Ethiopia |
| title_full | Prevalence and predictors of dyslipidemia among HAART treated and HAART naive HIV positive clients attending Debre Tabor Hospital, Debre Tabor, Ethiopia |
| title_fullStr | Prevalence and predictors of dyslipidemia among HAART treated and HAART naive HIV positive clients attending Debre Tabor Hospital, Debre Tabor, Ethiopia |
| title_full_unstemmed | Prevalence and predictors of dyslipidemia among HAART treated and HAART naive HIV positive clients attending Debre Tabor Hospital, Debre Tabor, Ethiopia |
| title_short | Prevalence and predictors of dyslipidemia among HAART treated and HAART naive HIV positive clients attending Debre Tabor Hospital, Debre Tabor, Ethiopia |
| title_sort | prevalence and predictors of dyslipidemia among haart treated and haart naive hiv positive clients attending debre tabor hospital debre tabor ethiopia |
| topic | Dyslipidemia HAART HIV/AIDS Debre Tabor Ethiopia |
| url | http://www.sciencedirect.com/science/article/pii/S2405844022026305 |
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