Parvovirus in dermatology: A review
Abstract Parvovirus B19 is a small nonenveloped single‐stranded DNA virus belonging to the parvoviridae family. The dermatological manifestations are varied ranging from infective to inflammatory, but the most common among infective etiologies is erythema infectiosum, also known as the fifth disease...
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| Format: | Article |
| Language: | English |
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Wiley
2023-12-01
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| Series: | JEADV Clinical Practice |
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| Online Access: | https://doi.org/10.1002/jvc2.239 |
| _version_ | 1797435280082337792 |
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| author | Prajwal Pudasaini Kinnor Das Suraljit Gorai Sushil Paudel Sagar G.C. Sadiksha Adhikari Bibechan Thapa Ann John Kurien |
| author_facet | Prajwal Pudasaini Kinnor Das Suraljit Gorai Sushil Paudel Sagar G.C. Sadiksha Adhikari Bibechan Thapa Ann John Kurien |
| author_sort | Prajwal Pudasaini |
| collection | DOAJ |
| description | Abstract Parvovirus B19 is a small nonenveloped single‐stranded DNA virus belonging to the parvoviridae family. The dermatological manifestations are varied ranging from infective to inflammatory, but the most common among infective etiologies is erythema infectiosum, also known as the fifth disease or ‘slapped cheek’ disease, which is mildly contagious. Clinical corroboration of symptoms and signs with serum antibody levels has been seen in acute and persistent parvoviral infections. Other dermatological manifestations of parvovirus B19 infections include erythema multiforme, vasculitis, reticular erythema, maculopapular eruptions, pustular eruptions, papular‐purpuric gloves and socks syndrome (PPGSS) and Gianotti‐Crosti syndrome. Skin lesions are quite characteristic and begin with oedema and erythema symmetrically localized to the hands and feet. Subsequently, petechial and purpuric changes appear varying from a few millimetres in diameter to larger, confluent patches. The primary target of parvovirus B19 is the hematopoietic‐erythroid cell line, specifically near the pronormoblast stage and the vulnerability to cellular damage increases along the differentiation lineage. There's multimodal clinical phenotypic presentation seen in parvoviral infections. Among the clinical expression of HPV B19 infections, the most common is dermatologic, however other manifestations such as rheumatologic and hematologic are not uncommon. However, some infections can be asymptomatic, especially in immunocompetent hosts, whereas in others with haematological abnormalities, these can lead to aplastic cellular crises. |
| first_indexed | 2024-03-09T10:45:53Z |
| format | Article |
| id | doaj.art-d7493bd3bb2546dcacadeb56325d509e |
| institution | Directory Open Access Journal |
| issn | 2768-6566 |
| language | English |
| last_indexed | 2024-03-09T10:45:53Z |
| publishDate | 2023-12-01 |
| publisher | Wiley |
| record_format | Article |
| series | JEADV Clinical Practice |
| spelling | doaj.art-d7493bd3bb2546dcacadeb56325d509e2023-12-01T10:43:26ZengWileyJEADV Clinical Practice2768-65662023-12-012468969810.1002/jvc2.239Parvovirus in dermatology: A reviewPrajwal Pudasaini0Kinnor Das1Suraljit Gorai2Sushil Paudel3Sagar G.C.4Sadiksha Adhikari5Bibechan Thapa6Ann John Kurien7Department of Dermatology Civil Service Hospital, Government of Nepal Kathmandu NepalApollo Clinic Silchar Assam IndiaApollo Multispecialty Hospitals Kolkata West Bengal IndiaDepartment of Dermatology Civil Service Hospital, Government of Nepal Kathmandu NepalDepartment of Dermatology Civil Service Hospital, Government of Nepal Kathmandu NepalDepartment of Dermatology Civil Service Hospital, Government of Nepal Kathmandu NepalDepartment of Emergency and Inpatient Care Nepal National Hospital Kathmandu NepalDepartment of Dermatology Silchar Medical College and Hospital Assam IndiaAbstract Parvovirus B19 is a small nonenveloped single‐stranded DNA virus belonging to the parvoviridae family. The dermatological manifestations are varied ranging from infective to inflammatory, but the most common among infective etiologies is erythema infectiosum, also known as the fifth disease or ‘slapped cheek’ disease, which is mildly contagious. Clinical corroboration of symptoms and signs with serum antibody levels has been seen in acute and persistent parvoviral infections. Other dermatological manifestations of parvovirus B19 infections include erythema multiforme, vasculitis, reticular erythema, maculopapular eruptions, pustular eruptions, papular‐purpuric gloves and socks syndrome (PPGSS) and Gianotti‐Crosti syndrome. Skin lesions are quite characteristic and begin with oedema and erythema symmetrically localized to the hands and feet. Subsequently, petechial and purpuric changes appear varying from a few millimetres in diameter to larger, confluent patches. The primary target of parvovirus B19 is the hematopoietic‐erythroid cell line, specifically near the pronormoblast stage and the vulnerability to cellular damage increases along the differentiation lineage. There's multimodal clinical phenotypic presentation seen in parvoviral infections. Among the clinical expression of HPV B19 infections, the most common is dermatologic, however other manifestations such as rheumatologic and hematologic are not uncommon. However, some infections can be asymptomatic, especially in immunocompetent hosts, whereas in others with haematological abnormalities, these can lead to aplastic cellular crises.https://doi.org/10.1002/jvc2.239parvovirus infectionviral infection |
| spellingShingle | Prajwal Pudasaini Kinnor Das Suraljit Gorai Sushil Paudel Sagar G.C. Sadiksha Adhikari Bibechan Thapa Ann John Kurien Parvovirus in dermatology: A review JEADV Clinical Practice parvovirus infection viral infection |
| title | Parvovirus in dermatology: A review |
| title_full | Parvovirus in dermatology: A review |
| title_fullStr | Parvovirus in dermatology: A review |
| title_full_unstemmed | Parvovirus in dermatology: A review |
| title_short | Parvovirus in dermatology: A review |
| title_sort | parvovirus in dermatology a review |
| topic | parvovirus infection viral infection |
| url | https://doi.org/10.1002/jvc2.239 |
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