Irisin ameliorates myocardial ischemia-reperfusion injury by modulating gut microbiota and intestinal permeability in rats
Recently, myocardial ischemia-reperfusion (I/R) injury was suggested associated with intestinal flora. However, irisin has demonstrated beneficial effects on myocardial I/R injury, thus increasing interest in exploring its mechanism. Therefore, whether irisin interferes in gut microbiota and gut muc...
| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Public Library of Science (PLoS)
2023-01-01
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| Series: | PLoS ONE |
| Online Access: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473488/?tool=EBI |
| _version_ | 1797690820180049920 |
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| author | Qingqing Liu Yu Zhu Guangyao Li Tiantian Guo Mengtong Jin Duan Xi Shuai Wang Xuezhi Liu Shuming Guo Hui Liu Jiamao Fan Ronghua Liu |
| author_facet | Qingqing Liu Yu Zhu Guangyao Li Tiantian Guo Mengtong Jin Duan Xi Shuai Wang Xuezhi Liu Shuming Guo Hui Liu Jiamao Fan Ronghua Liu |
| author_sort | Qingqing Liu |
| collection | DOAJ |
| description | Recently, myocardial ischemia-reperfusion (I/R) injury was suggested associated with intestinal flora. However, irisin has demonstrated beneficial effects on myocardial I/R injury, thus increasing interest in exploring its mechanism. Therefore, whether irisin interferes in gut microbiota and gut mucosal barrier during myocardial I/R injury was investigated in the present study. Irisin was found to reduce the infiltration of inflammatory cells and fracture in myocardial tissue, myocardial enzyme levels, and the myocardial infarction (MI) area. In addition, the data showed that irisin reverses I/R-induced gut dysbiosis as indicated by the decreased abundance of Actinobacteriota and the increased abundance of Firmicutes, and maintains intestinal barrier integrity, reduces metabolic endotoxemia, and inhibits the production of proinflammatory cytokines interleukin 1β (IL-1β), interleukin 6 (IL-6), and tumor necrosis factor α (TNF-α). Based on the results, irisin could be a good candidate for ameliorating myocardial I/R injury and associated diseases by alleviating gut dysbiosis, endothelial dysfunction and anti-inflammatory properties. |
| first_indexed | 2024-03-12T02:05:37Z |
| format | Article |
| id | doaj.art-d7494d22df4f403b9251a22532e2cdf4 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-03-12T02:05:37Z |
| publishDate | 2023-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-d7494d22df4f403b9251a22532e2cdf42023-09-07T05:31:43ZengPublic Library of Science (PLoS)PLoS ONE1932-62032023-01-01189Irisin ameliorates myocardial ischemia-reperfusion injury by modulating gut microbiota and intestinal permeability in ratsQingqing LiuYu ZhuGuangyao LiTiantian GuoMengtong JinDuan XiShuai WangXuezhi LiuShuming GuoHui LiuJiamao FanRonghua LiuRecently, myocardial ischemia-reperfusion (I/R) injury was suggested associated with intestinal flora. However, irisin has demonstrated beneficial effects on myocardial I/R injury, thus increasing interest in exploring its mechanism. Therefore, whether irisin interferes in gut microbiota and gut mucosal barrier during myocardial I/R injury was investigated in the present study. Irisin was found to reduce the infiltration of inflammatory cells and fracture in myocardial tissue, myocardial enzyme levels, and the myocardial infarction (MI) area. In addition, the data showed that irisin reverses I/R-induced gut dysbiosis as indicated by the decreased abundance of Actinobacteriota and the increased abundance of Firmicutes, and maintains intestinal barrier integrity, reduces metabolic endotoxemia, and inhibits the production of proinflammatory cytokines interleukin 1β (IL-1β), interleukin 6 (IL-6), and tumor necrosis factor α (TNF-α). Based on the results, irisin could be a good candidate for ameliorating myocardial I/R injury and associated diseases by alleviating gut dysbiosis, endothelial dysfunction and anti-inflammatory properties.https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473488/?tool=EBI |
| spellingShingle | Qingqing Liu Yu Zhu Guangyao Li Tiantian Guo Mengtong Jin Duan Xi Shuai Wang Xuezhi Liu Shuming Guo Hui Liu Jiamao Fan Ronghua Liu Irisin ameliorates myocardial ischemia-reperfusion injury by modulating gut microbiota and intestinal permeability in rats PLoS ONE |
| title | Irisin ameliorates myocardial ischemia-reperfusion injury by modulating gut microbiota and intestinal permeability in rats |
| title_full | Irisin ameliorates myocardial ischemia-reperfusion injury by modulating gut microbiota and intestinal permeability in rats |
| title_fullStr | Irisin ameliorates myocardial ischemia-reperfusion injury by modulating gut microbiota and intestinal permeability in rats |
| title_full_unstemmed | Irisin ameliorates myocardial ischemia-reperfusion injury by modulating gut microbiota and intestinal permeability in rats |
| title_short | Irisin ameliorates myocardial ischemia-reperfusion injury by modulating gut microbiota and intestinal permeability in rats |
| title_sort | irisin ameliorates myocardial ischemia reperfusion injury by modulating gut microbiota and intestinal permeability in rats |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10473488/?tool=EBI |
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