A comparative study of cardiovascular risk stratification methods in type 1 diabetes mellitus patients
Abstract The Steno Diabetes Center Copenhagen developed the Steno T1 Risk Engine (ST1RE) to predict cardiovascular events, encompassing fatal and nonfatal ischemic heart disease, ischemic stroke, heart failure, and peripheral arterial disease in type 1 diabetes mellitus(T1DM). The current study inve...
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| Format: | Article |
| Language: | English |
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BMC
2024-01-01
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| Series: | Diabetology & Metabolic Syndrome |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s13098-023-01224-5 |
| _version_ | 1797355679019696128 |
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| author | Fabiano Malard de Araujo Fábio Vasconcellos Comim Rodrigo N. Lamounier Natália F. Pena Virgínia C. Fajardo Regina Bicalho G. de Faria Yuri M. Silva Márcio Weissheimer Lauria |
| author_facet | Fabiano Malard de Araujo Fábio Vasconcellos Comim Rodrigo N. Lamounier Natália F. Pena Virgínia C. Fajardo Regina Bicalho G. de Faria Yuri M. Silva Márcio Weissheimer Lauria |
| author_sort | Fabiano Malard de Araujo |
| collection | DOAJ |
| description | Abstract The Steno Diabetes Center Copenhagen developed the Steno T1 Risk Engine (ST1RE) to predict cardiovascular events, encompassing fatal and nonfatal ischemic heart disease, ischemic stroke, heart failure, and peripheral arterial disease in type 1 diabetes mellitus(T1DM). The current study investigated the agreement between ST1RE and the Brazilian Society for Endocrinology and Metabology (SBEM) classification. Participants were included in the study if diagnosed with T1DM and had at least one outpatient visit in 2021. Patients with established cardiovascular disease and chronic kidney disease on dialysis were excluded. Clinical parameters were obtained from medical records, such as age, body mass index (BMI), blood pressure, physical activity, current smoking, microvascular target organ damage, levels of low-density lipoprotein cholesterol, creatinine, glycated hemoglobin (HbA1c), and albuminuria. Overall, 92 patients (38 males and 53 females) with an age median (P25; P75) of 33 years (25.5;42.5), BMI of 24.8 + 4.1 kg/m2, and duration of diabetes (mean ± SD) of 23.4 + 9.5 years were evaluated. There were no differences considering the gender for most analyzed variables, but a higher proportion of women exhibited microvascular complications such as microalbuminuria, macroalbuminuria, and retinopathy. Our results show a weak agreement in the 10-year cardiovascular risk estimation between SBEM and ST1RE classifications. According to SBEM criteria, 72.8% of patients were considered high-risk, while only 15.2% of patients received the same classification using ST1RE. The dissimilarities between these two classifications were also evident when age and gender factors were compared. While 60% of patients under 35 years were classified as high risk according to SBEM criteria, only 1.8% received this stratification risk in the ST1RE classification. The results indicate a low agreement between the 10-year cardiovascular event risk classification by SBEM and the classification by ST1RE for type 1 diabetes patients without established cardiovascular disease. |
| first_indexed | 2024-03-08T14:14:35Z |
| format | Article |
| id | doaj.art-d749ed9280644eeab3248d9c21f63eee |
| institution | Directory Open Access Journal |
| issn | 1758-5996 |
| language | English |
| last_indexed | 2024-03-08T14:14:35Z |
| publishDate | 2024-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Diabetology & Metabolic Syndrome |
| spelling | doaj.art-d749ed9280644eeab3248d9c21f63eee2024-01-14T12:30:50ZengBMCDiabetology & Metabolic Syndrome1758-59962024-01-011611710.1186/s13098-023-01224-5A comparative study of cardiovascular risk stratification methods in type 1 diabetes mellitus patientsFabiano Malard de Araujo0Fábio Vasconcellos Comim1Rodrigo N. Lamounier2Natália F. Pena3Virgínia C. Fajardo4Regina Bicalho G. de Faria5Yuri M. Silva6Márcio Weissheimer Lauria7Hospital das Clínicas da Universidade Federal de Minas GeraisUniversidade Federal de Minas GeraisUniversidade Federal de Minas GeraisUniversidade Federal de Minas GeraisUniversidade Federal de Minas GeraisUniversidade Federal de Minas GeraisUniversidade Federal de Minas GeraisUniversidade Federal de Minas GeraisAbstract The Steno Diabetes Center Copenhagen developed the Steno T1 Risk Engine (ST1RE) to predict cardiovascular events, encompassing fatal and nonfatal ischemic heart disease, ischemic stroke, heart failure, and peripheral arterial disease in type 1 diabetes mellitus(T1DM). The current study investigated the agreement between ST1RE and the Brazilian Society for Endocrinology and Metabology (SBEM) classification. Participants were included in the study if diagnosed with T1DM and had at least one outpatient visit in 2021. Patients with established cardiovascular disease and chronic kidney disease on dialysis were excluded. Clinical parameters were obtained from medical records, such as age, body mass index (BMI), blood pressure, physical activity, current smoking, microvascular target organ damage, levels of low-density lipoprotein cholesterol, creatinine, glycated hemoglobin (HbA1c), and albuminuria. Overall, 92 patients (38 males and 53 females) with an age median (P25; P75) of 33 years (25.5;42.5), BMI of 24.8 + 4.1 kg/m2, and duration of diabetes (mean ± SD) of 23.4 + 9.5 years were evaluated. There were no differences considering the gender for most analyzed variables, but a higher proportion of women exhibited microvascular complications such as microalbuminuria, macroalbuminuria, and retinopathy. Our results show a weak agreement in the 10-year cardiovascular risk estimation between SBEM and ST1RE classifications. According to SBEM criteria, 72.8% of patients were considered high-risk, while only 15.2% of patients received the same classification using ST1RE. The dissimilarities between these two classifications were also evident when age and gender factors were compared. While 60% of patients under 35 years were classified as high risk according to SBEM criteria, only 1.8% received this stratification risk in the ST1RE classification. The results indicate a low agreement between the 10-year cardiovascular event risk classification by SBEM and the classification by ST1RE for type 1 diabetes patients without established cardiovascular disease.https://doi.org/10.1186/s13098-023-01224-5Cardiovascular riskType 1 diabetes mellitusSteno calculatorST1RE |
| spellingShingle | Fabiano Malard de Araujo Fábio Vasconcellos Comim Rodrigo N. Lamounier Natália F. Pena Virgínia C. Fajardo Regina Bicalho G. de Faria Yuri M. Silva Márcio Weissheimer Lauria A comparative study of cardiovascular risk stratification methods in type 1 diabetes mellitus patients Diabetology & Metabolic Syndrome Cardiovascular risk Type 1 diabetes mellitus Steno calculator ST1RE |
| title | A comparative study of cardiovascular risk stratification methods in type 1 diabetes mellitus patients |
| title_full | A comparative study of cardiovascular risk stratification methods in type 1 diabetes mellitus patients |
| title_fullStr | A comparative study of cardiovascular risk stratification methods in type 1 diabetes mellitus patients |
| title_full_unstemmed | A comparative study of cardiovascular risk stratification methods in type 1 diabetes mellitus patients |
| title_short | A comparative study of cardiovascular risk stratification methods in type 1 diabetes mellitus patients |
| title_sort | comparative study of cardiovascular risk stratification methods in type 1 diabetes mellitus patients |
| topic | Cardiovascular risk Type 1 diabetes mellitus Steno calculator ST1RE |
| url | https://doi.org/10.1186/s13098-023-01224-5 |
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