Cancer-Related Stroke: An Emerging Subtype of Ischemic Stroke with Unique Pathomechanisms
Systemic cancer and ischemic stroke are common conditions and two of the most frequent causes of death among the elderly. The association between cancer and stroke has been reported worldwide. Stroke causes severe disability for cancer patients, while cancer increases the risk of stroke. Moreover, c...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Korean Stroke Society
2020-01-01
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| Series: | Journal of Stroke |
| Subjects: | |
| Online Access: | http://www.j-stroke.org/upload/pdf/jos-2019-02278.pdf |
| _version_ | 1818265231309144064 |
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| author | Oh Young Bang Jong-Won Chung Mi Ji Lee Woo-Keun Seo Gyeong-Moon Kim Myung-Ju Ahn |
| author_facet | Oh Young Bang Jong-Won Chung Mi Ji Lee Woo-Keun Seo Gyeong-Moon Kim Myung-Ju Ahn |
| author_sort | Oh Young Bang |
| collection | DOAJ |
| description | Systemic cancer and ischemic stroke are common conditions and two of the most frequent causes of death among the elderly. The association between cancer and stroke has been reported worldwide. Stroke causes severe disability for cancer patients, while cancer increases the risk of stroke. Moreover, cancer-related stroke is expected to increase due to advances in cancer treatment and an aging population worldwide. Because cancer and stroke share risk factors (such as smoking and obesity) and treatment of cancer can increase the risk of stroke (e.g., accelerated atherosclerosis after radiation therapy), cancer may accelerate conventional stroke mechanisms (i.e., atherosclerosis, small vessel disease, and cardiac thrombus). In addition, active cancer and chemotherapy may enhance thrombin generation causing stroke related to coagulopathy. Patients with stroke due to cancer-related coagulopathy showed the characteristics findings of etiologic work ups, D-dimer levels, and infarct patterns. In this review, we summarized the frequency of cancer-related stroke among patients with ischemic stroke, mechanisms of stroke with in cancer patients, and evaluation and treatment of cancer-related stroke. We discussed the possibility of cancer-related stroke as a stroke subtype, and presented the most recent discoveries in the pathomechanisms and treatment of stroke due to cancer-related coagulopathy. |
| first_indexed | 2024-12-12T19:47:31Z |
| format | Article |
| id | doaj.art-d74d207539dc4f5480f9230ff8556dbb |
| institution | Directory Open Access Journal |
| issn | 2287-6391 2287-6405 |
| language | English |
| last_indexed | 2024-12-12T19:47:31Z |
| publishDate | 2020-01-01 |
| publisher | Korean Stroke Society |
| record_format | Article |
| series | Journal of Stroke |
| spelling | doaj.art-d74d207539dc4f5480f9230ff8556dbb2022-12-22T00:14:04ZengKorean Stroke SocietyJournal of Stroke2287-63912287-64052020-01-0122111010.5853/jos.2019.02278300Cancer-Related Stroke: An Emerging Subtype of Ischemic Stroke with Unique PathomechanismsOh Young Bang0Jong-Won Chung1Mi Ji Lee2Woo-Keun Seo3Gyeong-Moon Kim4Myung-Ju Ahn5 Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea Department of Neurology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea Department of Hemato-Oncology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, KoreaSystemic cancer and ischemic stroke are common conditions and two of the most frequent causes of death among the elderly. The association between cancer and stroke has been reported worldwide. Stroke causes severe disability for cancer patients, while cancer increases the risk of stroke. Moreover, cancer-related stroke is expected to increase due to advances in cancer treatment and an aging population worldwide. Because cancer and stroke share risk factors (such as smoking and obesity) and treatment of cancer can increase the risk of stroke (e.g., accelerated atherosclerosis after radiation therapy), cancer may accelerate conventional stroke mechanisms (i.e., atherosclerosis, small vessel disease, and cardiac thrombus). In addition, active cancer and chemotherapy may enhance thrombin generation causing stroke related to coagulopathy. Patients with stroke due to cancer-related coagulopathy showed the characteristics findings of etiologic work ups, D-dimer levels, and infarct patterns. In this review, we summarized the frequency of cancer-related stroke among patients with ischemic stroke, mechanisms of stroke with in cancer patients, and evaluation and treatment of cancer-related stroke. We discussed the possibility of cancer-related stroke as a stroke subtype, and presented the most recent discoveries in the pathomechanisms and treatment of stroke due to cancer-related coagulopathy.http://www.j-stroke.org/upload/pdf/jos-2019-02278.pdfstrokeneoplasmscoagulopathysubtypethrombosiscancer |
| spellingShingle | Oh Young Bang Jong-Won Chung Mi Ji Lee Woo-Keun Seo Gyeong-Moon Kim Myung-Ju Ahn Cancer-Related Stroke: An Emerging Subtype of Ischemic Stroke with Unique Pathomechanisms Journal of Stroke stroke neoplasms coagulopathy subtype thrombosis cancer |
| title | Cancer-Related Stroke: An Emerging Subtype of Ischemic Stroke with Unique Pathomechanisms |
| title_full | Cancer-Related Stroke: An Emerging Subtype of Ischemic Stroke with Unique Pathomechanisms |
| title_fullStr | Cancer-Related Stroke: An Emerging Subtype of Ischemic Stroke with Unique Pathomechanisms |
| title_full_unstemmed | Cancer-Related Stroke: An Emerging Subtype of Ischemic Stroke with Unique Pathomechanisms |
| title_short | Cancer-Related Stroke: An Emerging Subtype of Ischemic Stroke with Unique Pathomechanisms |
| title_sort | cancer related stroke an emerging subtype of ischemic stroke with unique pathomechanisms |
| topic | stroke neoplasms coagulopathy subtype thrombosis cancer |
| url | http://www.j-stroke.org/upload/pdf/jos-2019-02278.pdf |
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