The Transcription Factor c-Maf Promotes the Differentiation of Follicular Helper T Cells
Follicular helper T cells (Tfh) have been identified as the primary cell subpopulation regulating B cell responses in germinal centers, thus supporting high-affinity antibody production. Among the transcription factors orchestrating Tfh cell differentiation and function, the role played by the proto...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-04-01
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| Series: | Frontiers in Immunology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fimmu.2017.00480/full |
| _version_ | 1818614557958995968 |
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| author | Fabienne Andris Sébastien Denanglaire Maelle Anciaux Mélanie Hercor Hind Hussein Oberdan Leo |
| author_facet | Fabienne Andris Sébastien Denanglaire Maelle Anciaux Mélanie Hercor Hind Hussein Oberdan Leo |
| author_sort | Fabienne Andris |
| collection | DOAJ |
| description | Follicular helper T cells (Tfh) have been identified as the primary cell subpopulation regulating B cell responses in germinal centers, thus supporting high-affinity antibody production. Among the transcription factors orchestrating Tfh cell differentiation and function, the role played by the proto-oncogene c-Maf remains poorly characterized. We report herein that selective loss of c-Maf expression in the T cell compartment results in defective development of Tfh cells in response to both antigen/adjuvant vaccinations and commensal intestinal bacteria. Accordingly, c-Maf expression in T cells was essential for the development and high-affinity antibody secretion in vaccinated animals. c-Maf was expressed early, concomitantly to BCL6, in Tfh cell precursors and found to regulate Tfh fate in a cell-autonomous fashion. Altogether, our findings reveal a novel, non-redundant, function for c-Maf in the differentiation of Tfh cells and the regulation of humoral immune responses to T-cell-dependent antigens. |
| first_indexed | 2024-12-16T16:19:55Z |
| format | Article |
| id | doaj.art-d750791585f340e597518480782efe4a |
| institution | Directory Open Access Journal |
| issn | 1664-3224 |
| language | English |
| last_indexed | 2024-12-16T16:19:55Z |
| publishDate | 2017-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Immunology |
| spelling | doaj.art-d750791585f340e597518480782efe4a2022-12-21T22:24:57ZengFrontiers Media S.A.Frontiers in Immunology1664-32242017-04-01810.3389/fimmu.2017.00480259871The Transcription Factor c-Maf Promotes the Differentiation of Follicular Helper T CellsFabienne Andris0Sébastien Denanglaire1Maelle Anciaux2Mélanie Hercor3Hind Hussein4Oberdan Leo5Laboratoire d’Immunobiologie, Université Libre de Bruxelles, Brussels, BelgiumLaboratoire d’Immunobiologie, Université Libre de Bruxelles, Brussels, BelgiumLaboratoire d’Immunobiologie, Université Libre de Bruxelles, Brussels, BelgiumLaboratoire d’Immunobiologie, Université Libre de Bruxelles, Brussels, BelgiumLaboratoire d’Immunobiologie, Université Libre de Bruxelles, Brussels, BelgiumLaboratoire d’Immunobiologie, Université Libre de Bruxelles, Brussels, BelgiumFollicular helper T cells (Tfh) have been identified as the primary cell subpopulation regulating B cell responses in germinal centers, thus supporting high-affinity antibody production. Among the transcription factors orchestrating Tfh cell differentiation and function, the role played by the proto-oncogene c-Maf remains poorly characterized. We report herein that selective loss of c-Maf expression in the T cell compartment results in defective development of Tfh cells in response to both antigen/adjuvant vaccinations and commensal intestinal bacteria. Accordingly, c-Maf expression in T cells was essential for the development and high-affinity antibody secretion in vaccinated animals. c-Maf was expressed early, concomitantly to BCL6, in Tfh cell precursors and found to regulate Tfh fate in a cell-autonomous fashion. Altogether, our findings reveal a novel, non-redundant, function for c-Maf in the differentiation of Tfh cells and the regulation of humoral immune responses to T-cell-dependent antigens.http://journal.frontiersin.org/article/10.3389/fimmu.2017.00480/fullCD4+ T lymphocytesfollicular helper T cellshumoral responsec-MafT cell differentiation |
| spellingShingle | Fabienne Andris Sébastien Denanglaire Maelle Anciaux Mélanie Hercor Hind Hussein Oberdan Leo The Transcription Factor c-Maf Promotes the Differentiation of Follicular Helper T Cells Frontiers in Immunology CD4+ T lymphocytes follicular helper T cells humoral response c-Maf T cell differentiation |
| title | The Transcription Factor c-Maf Promotes the Differentiation of Follicular Helper T Cells |
| title_full | The Transcription Factor c-Maf Promotes the Differentiation of Follicular Helper T Cells |
| title_fullStr | The Transcription Factor c-Maf Promotes the Differentiation of Follicular Helper T Cells |
| title_full_unstemmed | The Transcription Factor c-Maf Promotes the Differentiation of Follicular Helper T Cells |
| title_short | The Transcription Factor c-Maf Promotes the Differentiation of Follicular Helper T Cells |
| title_sort | transcription factor c maf promotes the differentiation of follicular helper t cells |
| topic | CD4+ T lymphocytes follicular helper T cells humoral response c-Maf T cell differentiation |
| url | http://journal.frontiersin.org/article/10.3389/fimmu.2017.00480/full |
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