The Transcription Factor c-Maf Promotes the Differentiation of Follicular Helper T Cells

The Transcription Factor c-Maf Promotes the Differentiation of Follicular Helper T Cells

Follicular helper T cells (Tfh) have been identified as the primary cell subpopulation regulating B cell responses in germinal centers, thus supporting high-affinity antibody production. Among the transcription factors orchestrating Tfh cell differentiation and function, the role played by the proto...

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Bibliographic Details
Main Authors: Fabienne Andris, Sébastien Denanglaire, Maelle Anciaux, Mélanie Hercor, Hind Hussein, Oberdan Leo
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-04-01
Series:Frontiers in Immunology
Subjects:
CD4+ T lymphocytes
follicular helper T cells
humoral response
c-Maf
T cell differentiation
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2017.00480/full

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