Characterization and evaluation of Bletilla striata polysaccharide/ethanol extract composite multifunctional sponges
Development of a fully functional dressing that can be applied throughout wound healing remains challenging. In this study, Bletilla striata polysaccharide (BSP) and the ethanol extract of B. striata (EEB) were physically blended and vacuum freeze-dried into a new medical dressing with various funct...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-08-01
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| Series: | Materials & Design |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127521003592 |
| _version_ | 1819107711534497792 |
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| author | Wen Cheng Fangmei Zhou Bingqi Zhu Xinghong Ding Jingjing Lu Chaodong Qian Xiaoqing Ye Zhishan Ding |
| author_facet | Wen Cheng Fangmei Zhou Bingqi Zhu Xinghong Ding Jingjing Lu Chaodong Qian Xiaoqing Ye Zhishan Ding |
| author_sort | Wen Cheng |
| collection | DOAJ |
| description | Development of a fully functional dressing that can be applied throughout wound healing remains challenging. In this study, Bletilla striata polysaccharide (BSP) and the ethanol extract of B. striata (EEB) were physically blended and vacuum freeze-dried into a new medical dressing with various functions, such as hemostasis, anti-inflammatory, antibacterial and wound healing promotion. The in vivo and in vitro blood coagulation evaluation results showed that the most obvious hemostasis effects coming from the EEB25 sponge was probably due to good water absorption capacity. The drug sensitivity test results showed that the sponges presented a good antibacterial effect originated from the addition of EEB. In addition, the EEB25 sponge showed significant anti-inflammatory effects, as well as excellent biodegradability and biocompatibility. The full-thickness wound experiment illustrated the wound healing rates of EEB25 group on the 8th day and 16th day was 82.76 ± 2.78% and 95.36 ± 3.72%, respectively, which showed significant differences (p < 0.05) in comparison to the model group. Histological observations showed that the EEB25 group formed dense collagen fibers, granulation tissue and numerous new blood vessels on the 16th day, with the skin basically cured. Therefore, BSP/EEB multifunctional composite sponge provided a new perspective for the safe application of wound dressings. |
| first_indexed | 2024-12-22T02:58:23Z |
| format | Article |
| id | doaj.art-d7518fbea4904c708cf9873eccb77148 |
| institution | Directory Open Access Journal |
| issn | 0264-1275 |
| language | English |
| last_indexed | 2024-12-22T02:58:23Z |
| publishDate | 2021-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials & Design |
| spelling | doaj.art-d7518fbea4904c708cf9873eccb771482022-12-21T18:41:13ZengElsevierMaterials & Design0264-12752021-08-01206109806Characterization and evaluation of Bletilla striata polysaccharide/ethanol extract composite multifunctional spongesWen Cheng0Fangmei Zhou1Bingqi Zhu2Xinghong Ding3Jingjing Lu4Chaodong Qian5Xiaoqing Ye6Zhishan Ding7College of Life Sciences, Zhejiang Chinese Medical University, No.548, Binjiang District, Hangzhou 310053, Zhejiang, People’s Republic of ChinaCollege of Medical Technology, Zhejiang Chinese Medical University, No.548, Binjiang District, Hangzhou 310053, Zhejiang, People’s Republic of ChinaCollege of Medical Technology, Zhejiang Chinese Medical University, No.548, Binjiang District, Hangzhou 310053, Zhejiang, People’s Republic of ChinaCollege of Basic Medical Science, Zhejiang Chinese Medical University, No.548, Binjiang District, Hangzhou 310053, Zhejiang, People’s Republic of ChinaCollege of Life Sciences, Zhejiang Chinese Medical University, No.548, Binjiang District, Hangzhou 310053, Zhejiang, People’s Republic of ChinaCollege of Life Sciences, Zhejiang Chinese Medical University, No.548, Binjiang District, Hangzhou 310053, Zhejiang, People’s Republic of ChinaCollege of Medical Technology, Zhejiang Chinese Medical University, No.548, Binjiang District, Hangzhou 310053, Zhejiang, People’s Republic of ChinaCollege of Medical Technology, Zhejiang Chinese Medical University, No.548, Binjiang District, Hangzhou 310053, Zhejiang, People’s Republic of China; Corresponding author.Development of a fully functional dressing that can be applied throughout wound healing remains challenging. In this study, Bletilla striata polysaccharide (BSP) and the ethanol extract of B. striata (EEB) were physically blended and vacuum freeze-dried into a new medical dressing with various functions, such as hemostasis, anti-inflammatory, antibacterial and wound healing promotion. The in vivo and in vitro blood coagulation evaluation results showed that the most obvious hemostasis effects coming from the EEB25 sponge was probably due to good water absorption capacity. The drug sensitivity test results showed that the sponges presented a good antibacterial effect originated from the addition of EEB. In addition, the EEB25 sponge showed significant anti-inflammatory effects, as well as excellent biodegradability and biocompatibility. The full-thickness wound experiment illustrated the wound healing rates of EEB25 group on the 8th day and 16th day was 82.76 ± 2.78% and 95.36 ± 3.72%, respectively, which showed significant differences (p < 0.05) in comparison to the model group. Histological observations showed that the EEB25 group formed dense collagen fibers, granulation tissue and numerous new blood vessels on the 16th day, with the skin basically cured. Therefore, BSP/EEB multifunctional composite sponge provided a new perspective for the safe application of wound dressings.http://www.sciencedirect.com/science/article/pii/S0264127521003592Bletilla striata polysaccharideEthanol extract substanceHemostasisAnti-inflammatoryAntibacterialWound dressing |
| spellingShingle | Wen Cheng Fangmei Zhou Bingqi Zhu Xinghong Ding Jingjing Lu Chaodong Qian Xiaoqing Ye Zhishan Ding Characterization and evaluation of Bletilla striata polysaccharide/ethanol extract composite multifunctional sponges Materials & Design Bletilla striata polysaccharide Ethanol extract substance Hemostasis Anti-inflammatory Antibacterial Wound dressing |
| title | Characterization and evaluation of Bletilla striata polysaccharide/ethanol extract composite multifunctional sponges |
| title_full | Characterization and evaluation of Bletilla striata polysaccharide/ethanol extract composite multifunctional sponges |
| title_fullStr | Characterization and evaluation of Bletilla striata polysaccharide/ethanol extract composite multifunctional sponges |
| title_full_unstemmed | Characterization and evaluation of Bletilla striata polysaccharide/ethanol extract composite multifunctional sponges |
| title_short | Characterization and evaluation of Bletilla striata polysaccharide/ethanol extract composite multifunctional sponges |
| title_sort | characterization and evaluation of bletilla striata polysaccharide ethanol extract composite multifunctional sponges |
| topic | Bletilla striata polysaccharide Ethanol extract substance Hemostasis Anti-inflammatory Antibacterial Wound dressing |
| url | http://www.sciencedirect.com/science/article/pii/S0264127521003592 |
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