Salivary Osteopontin as a Potential Biomarker for Oral Mucositis
Osteopontin (OPN), a multifunctional phosphoglycoprotein also presents in saliva, plays a crucial role in tumour progression, inflammation and mucosal protection. Mucosal barrier injury due to high-dose conditioning regimen administered during autologous and allogeneic peripheral stem cell transplan...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Metabolites |
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| Online Access: | https://www.mdpi.com/2218-1989/11/4/208 |
| _version_ | 1797539579950006272 |
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| author | Enikő Gebri Attila Kiss Ferenc Tóth Tibor Hortobágyi |
| author_facet | Enikő Gebri Attila Kiss Ferenc Tóth Tibor Hortobágyi |
| author_sort | Enikő Gebri |
| collection | DOAJ |
| description | Osteopontin (OPN), a multifunctional phosphoglycoprotein also presents in saliva, plays a crucial role in tumour progression, inflammation and mucosal protection. Mucosal barrier injury due to high-dose conditioning regimen administered during autologous and allogeneic peripheral stem cell transplantation (APSCT) has neither efficient therapy nor established biomarkers. Our aim was to assess the biomarker role of OPN during APSCT, with primary focus on oral mucositis (OM). Serum and salivary OPN levels were determined by ELISA in 10 patients during APSCT at four stages of transplantation (day −3/−7, 0, +7, +14), and in 23 respective healthy controls. Results: There was a negative correlation between both salivary and serum OPN levels and grade of OM severity during APSCT (<i>r</i> = −0.791, <i>p</i> = 0.019; <i>r</i> = −0.973, <i>p</i> = 0.001). Salivary OPN increased at days +7 (<i>p</i> = 0.011) and +14 (<i>p</i> = 0.034) compared to controls. Among patients, it was higher at day +14 compared to the time of admission (day −3/−7) (<i>p</i> = 0.039) and transplantation (day 0) (<i>p</i> = 0.011). Serum OPN remained elevated at all four stages of transplantation compared to controls (<i>p</i> = 0.013, <i>p</i> = 0.02, <i>p</i> = 0.011, <i>p</i> = 0.028). During APSCT elevated salivary OPN is a potential non-invasive biomarker of oral mucositis whereas the importance of high serum OPN warrants further studies. |
| first_indexed | 2024-03-10T12:47:51Z |
| format | Article |
| id | doaj.art-d75207d58a724fb99bb68e6e213723f1 |
| institution | Directory Open Access Journal |
| issn | 2218-1989 |
| language | English |
| last_indexed | 2024-03-10T12:47:51Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Metabolites |
| spelling | doaj.art-d75207d58a724fb99bb68e6e213723f12023-11-21T13:24:10ZengMDPI AGMetabolites2218-19892021-03-0111420810.3390/metabo11040208Salivary Osteopontin as a Potential Biomarker for Oral MucositisEnikő Gebri0Attila Kiss1Ferenc Tóth2Tibor Hortobágyi3Department of Dentoalveolar Surgery and Dental Outpatient Care, Faculty of Dentistry, University of Debrecen, Nagyerdei krt. 98, H-4032 Debrecen, HungaryDepartment of Hematopoietic Transplantation Centre, Faculty of Medicine, University of Debrecen, Nagyerdei krt. 98, H-4032 Debrecen, HungaryDepartment of Biomaterials and Prosthetic Dentistry, Faculty of Dentistry, University of Debrecen, Nagyerdei krt. 98, H-4032 Debrecen, HungaryInstitute of Pathology, Faculty of Medicine, University of Szeged, Állomás utca 1, H-6725 Szeged, HungaryOsteopontin (OPN), a multifunctional phosphoglycoprotein also presents in saliva, plays a crucial role in tumour progression, inflammation and mucosal protection. Mucosal barrier injury due to high-dose conditioning regimen administered during autologous and allogeneic peripheral stem cell transplantation (APSCT) has neither efficient therapy nor established biomarkers. Our aim was to assess the biomarker role of OPN during APSCT, with primary focus on oral mucositis (OM). Serum and salivary OPN levels were determined by ELISA in 10 patients during APSCT at four stages of transplantation (day −3/−7, 0, +7, +14), and in 23 respective healthy controls. Results: There was a negative correlation between both salivary and serum OPN levels and grade of OM severity during APSCT (<i>r</i> = −0.791, <i>p</i> = 0.019; <i>r</i> = −0.973, <i>p</i> = 0.001). Salivary OPN increased at days +7 (<i>p</i> = 0.011) and +14 (<i>p</i> = 0.034) compared to controls. Among patients, it was higher at day +14 compared to the time of admission (day −3/−7) (<i>p</i> = 0.039) and transplantation (day 0) (<i>p</i> = 0.011). Serum OPN remained elevated at all four stages of transplantation compared to controls (<i>p</i> = 0.013, <i>p</i> = 0.02, <i>p</i> = 0.011, <i>p</i> = 0.028). During APSCT elevated salivary OPN is a potential non-invasive biomarker of oral mucositis whereas the importance of high serum OPN warrants further studies.https://www.mdpi.com/2218-1989/11/4/208autologous peripheral stem-cell transplantation (APSCT)oral immunityoral mucositisosteopontinsalivary biomarkers |
| spellingShingle | Enikő Gebri Attila Kiss Ferenc Tóth Tibor Hortobágyi Salivary Osteopontin as a Potential Biomarker for Oral Mucositis Metabolites autologous peripheral stem-cell transplantation (APSCT) oral immunity oral mucositis osteopontin salivary biomarkers |
| title | Salivary Osteopontin as a Potential Biomarker for Oral Mucositis |
| title_full | Salivary Osteopontin as a Potential Biomarker for Oral Mucositis |
| title_fullStr | Salivary Osteopontin as a Potential Biomarker for Oral Mucositis |
| title_full_unstemmed | Salivary Osteopontin as a Potential Biomarker for Oral Mucositis |
| title_short | Salivary Osteopontin as a Potential Biomarker for Oral Mucositis |
| title_sort | salivary osteopontin as a potential biomarker for oral mucositis |
| topic | autologous peripheral stem-cell transplantation (APSCT) oral immunity oral mucositis osteopontin salivary biomarkers |
| url | https://www.mdpi.com/2218-1989/11/4/208 |
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