Exploring exercise-driven inhibition of pyroptosis: novel insights into treating diabetes mellitus and its complications
Diabetes mellitus (DM) and its complications are important, worldwide public health issues, exerting detrimental effects on human health and diminishing both quality of life and lifespan. Pyroptosis, as a new form of programmed cell death, plays a critical role in DM and its complications. Exercise...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2023-10-01
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| Series: | Frontiers in Endocrinology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1230646/full |
| _version_ | 1827800040399175680 |
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| author | Nan Li Liang Zhang Xintang Wang Yue Zhou Lijing Gong |
| author_facet | Nan Li Liang Zhang Xintang Wang Yue Zhou Lijing Gong |
| author_sort | Nan Li |
| collection | DOAJ |
| description | Diabetes mellitus (DM) and its complications are important, worldwide public health issues, exerting detrimental effects on human health and diminishing both quality of life and lifespan. Pyroptosis, as a new form of programmed cell death, plays a critical role in DM and its complications. Exercise has been shown to be an effective treatment for improving insulin sensitivity or preventing DM. However, the molecular mechanisms underlying the effects of exercise on pyroptosis-related diseases remain elusive. In this review, we provided a comprehensive elucidation of the molecular mechanisms underlying pyroptosis and the potential mechanism of exercise in the treatment of DM and its complications through the modulation of anti-pyroptosis-associated inflammasome pathways. Based on the existing evidence, further investigation into the mechanisms by which exercise inhibits pyroptosis through the regulation of inflammasome pathways holds promising potential for expanding preventive and therapeutic strategies for DM and facilitating the development of novel therapeutic interventions. |
| first_indexed | 2024-03-11T19:59:53Z |
| format | Article |
| id | doaj.art-d75258c6e68c49438a174d73634d39e8 |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-11T19:59:53Z |
| publishDate | 2023-10-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-d75258c6e68c49438a174d73634d39e82023-10-04T09:40:09ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-10-011410.3389/fendo.2023.12306461230646Exploring exercise-driven inhibition of pyroptosis: novel insights into treating diabetes mellitus and its complicationsNan Li0Liang Zhang1Xintang Wang2Yue Zhou3Lijing Gong4Department of Exercise Physiology, Beijing Sport University, Beijing, ChinaSchool of Strength and Conditioning Training, Beijing Sport University, Beijing, ChinaChina Institute of Sport and Health Science, Beijing Sport University, Beijing, ChinaDepartment of Exercise Physiology, Beijing Sport University, Beijing, ChinaKey Laboratory of Physical Fitness and Exercise, Ministry of Education, Beijing Sport University, Beijing, ChinaDiabetes mellitus (DM) and its complications are important, worldwide public health issues, exerting detrimental effects on human health and diminishing both quality of life and lifespan. Pyroptosis, as a new form of programmed cell death, plays a critical role in DM and its complications. Exercise has been shown to be an effective treatment for improving insulin sensitivity or preventing DM. However, the molecular mechanisms underlying the effects of exercise on pyroptosis-related diseases remain elusive. In this review, we provided a comprehensive elucidation of the molecular mechanisms underlying pyroptosis and the potential mechanism of exercise in the treatment of DM and its complications through the modulation of anti-pyroptosis-associated inflammasome pathways. Based on the existing evidence, further investigation into the mechanisms by which exercise inhibits pyroptosis through the regulation of inflammasome pathways holds promising potential for expanding preventive and therapeutic strategies for DM and facilitating the development of novel therapeutic interventions.https://www.frontiersin.org/articles/10.3389/fendo.2023.1230646/fullexercisediabetes mellituscomplicationspyroptosistherapy |
| spellingShingle | Nan Li Liang Zhang Xintang Wang Yue Zhou Lijing Gong Exploring exercise-driven inhibition of pyroptosis: novel insights into treating diabetes mellitus and its complications Frontiers in Endocrinology exercise diabetes mellitus complications pyroptosis therapy |
| title | Exploring exercise-driven inhibition of pyroptosis: novel insights into treating diabetes mellitus and its complications |
| title_full | Exploring exercise-driven inhibition of pyroptosis: novel insights into treating diabetes mellitus and its complications |
| title_fullStr | Exploring exercise-driven inhibition of pyroptosis: novel insights into treating diabetes mellitus and its complications |
| title_full_unstemmed | Exploring exercise-driven inhibition of pyroptosis: novel insights into treating diabetes mellitus and its complications |
| title_short | Exploring exercise-driven inhibition of pyroptosis: novel insights into treating diabetes mellitus and its complications |
| title_sort | exploring exercise driven inhibition of pyroptosis novel insights into treating diabetes mellitus and its complications |
| topic | exercise diabetes mellitus complications pyroptosis therapy |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1230646/full |
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