The role of N-myristoyltransferase 1 in tumour development
AbstractN-myristoyltransferase 1 (NMT1) is an indispensable eukaryotic enzyme that catalyses the transfer of myristoyl groups to the amino acid terminal residues of numerous proteins. This catalytic process is required for the growth and development of many eukaryotes and viruses. Elevated expressio...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2023-12-01
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| Series: | Annals of Medicine |
| Subjects: | |
| Online Access: | https://www.tandfonline.com/doi/10.1080/07853890.2023.2193425 |
| _version_ | 1797353768524709888 |
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| author | Hong Wang Xin Xu Jiayi Wang Yongxia Qiao |
| author_facet | Hong Wang Xin Xu Jiayi Wang Yongxia Qiao |
| author_sort | Hong Wang |
| collection | DOAJ |
| description | AbstractN-myristoyltransferase 1 (NMT1) is an indispensable eukaryotic enzyme that catalyses the transfer of myristoyl groups to the amino acid terminal residues of numerous proteins. This catalytic process is required for the growth and development of many eukaryotes and viruses. Elevated expression and activity of NMT1 is observed to varying degrees in a variety of tumour types (e.g. colon, lung and breast tumours). Furthermore, an elevated level of NMT1 in tumours is associated with poor survival. Therefore, a relationship exists between NMT1 and tumours. In this review, we discuss the underlying mechanisms by which NMT1 is associated with tumour development from the perspective of oncogene signalling, involvement in cellular metabolism, and endoplasmic reticulum stress. Several NMT inhibitors used in cancer treatment are introduced. The review will provide some directions for future research.Key MessagesElevated expression and activity of NMT1 is observed to varying degrees in a variety of tumour types which creates the possibility of targeting NMT1 in tumours.NMT1-mediated myristoylation plays a pivotal role in cancer cell metabolism and may be particularly relevant to cancer metastasis and drug resistance. These insights can be used to direct potential therapeutic avenues for NMT1 inhibitors. |
| first_indexed | 2024-03-08T13:35:48Z |
| format | Article |
| id | doaj.art-d7545759f84f49978eeac82fadba0e50 |
| institution | Directory Open Access Journal |
| issn | 0785-3890 1365-2060 |
| language | English |
| last_indexed | 2024-03-08T13:35:48Z |
| publishDate | 2023-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Annals of Medicine |
| spelling | doaj.art-d7545759f84f49978eeac82fadba0e502024-01-16T19:13:21ZengTaylor & Francis GroupAnnals of Medicine0785-38901365-20602023-12-015511422143010.1080/07853890.2023.2193425The role of N-myristoyltransferase 1 in tumour developmentHong Wang0Xin Xu1Jiayi Wang2Yongxia Qiao3School of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Clinical Laboratory, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Clinical Laboratory, Shanghai Chest Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaSchool of Public Health, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaAbstractN-myristoyltransferase 1 (NMT1) is an indispensable eukaryotic enzyme that catalyses the transfer of myristoyl groups to the amino acid terminal residues of numerous proteins. This catalytic process is required for the growth and development of many eukaryotes and viruses. Elevated expression and activity of NMT1 is observed to varying degrees in a variety of tumour types (e.g. colon, lung and breast tumours). Furthermore, an elevated level of NMT1 in tumours is associated with poor survival. Therefore, a relationship exists between NMT1 and tumours. In this review, we discuss the underlying mechanisms by which NMT1 is associated with tumour development from the perspective of oncogene signalling, involvement in cellular metabolism, and endoplasmic reticulum stress. Several NMT inhibitors used in cancer treatment are introduced. The review will provide some directions for future research.Key MessagesElevated expression and activity of NMT1 is observed to varying degrees in a variety of tumour types which creates the possibility of targeting NMT1 in tumours.NMT1-mediated myristoylation plays a pivotal role in cancer cell metabolism and may be particularly relevant to cancer metastasis and drug resistance. These insights can be used to direct potential therapeutic avenues for NMT1 inhibitors.https://www.tandfonline.com/doi/10.1080/07853890.2023.2193425N-myristoyltransferase 1myristoylationtumourNMT1 inhibitor |
| spellingShingle | Hong Wang Xin Xu Jiayi Wang Yongxia Qiao The role of N-myristoyltransferase 1 in tumour development Annals of Medicine N-myristoyltransferase 1 myristoylation tumour NMT1 inhibitor |
| title | The role of N-myristoyltransferase 1 in tumour development |
| title_full | The role of N-myristoyltransferase 1 in tumour development |
| title_fullStr | The role of N-myristoyltransferase 1 in tumour development |
| title_full_unstemmed | The role of N-myristoyltransferase 1 in tumour development |
| title_short | The role of N-myristoyltransferase 1 in tumour development |
| title_sort | role of n myristoyltransferase 1 in tumour development |
| topic | N-myristoyltransferase 1 myristoylation tumour NMT1 inhibitor |
| url | https://www.tandfonline.com/doi/10.1080/07853890.2023.2193425 |
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