c-MET positivity and its relationship with histopathological findings in gastric carcinomas exhibiting HER2 gene expression
Context: Co-expressions of receptor tyrosine kinases such as c-MET and HER2 were reported in many studies. The concomitant expression is associated with more aggressive clinical course. Aims: In this study, it was intended to investigate the correlation of the positivity of c-MET and HER2 with histo...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2022-01-01
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| Series: | Indian Journal of Pathology and Microbiology |
| Subjects: | |
| Online Access: | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2022;volume=65;issue=4;spage=786;epage=790;aulast=Coskun |
| _version_ | 1797963532125339648 |
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| author | Ferhat Coskun Semin Ayhan Ayca Tan Aydin Isisag |
| author_facet | Ferhat Coskun Semin Ayhan Ayca Tan Aydin Isisag |
| author_sort | Ferhat Coskun |
| collection | DOAJ |
| description | Context: Co-expressions of receptor tyrosine kinases such as c-MET and HER2 were reported in many studies. The concomitant expression is associated with more aggressive clinical course. Aims: In this study, it was intended to investigate the correlation of the positivity of c-MET and HER2 with histopathologic findings and their impacts on prognosis. Subjects and Methods: After the decision of the ethics committee, a total of 64 cases, whose HER 2 status was studied by dual silver in situ hybridization/immunohistochemistry method, were included in the study. Immunohistochemical staining for c-MET was performed to all cases and the evaluation was performed similarly to the criteria for HER2 evaluation, but cytoplasmic staining was also considered significant. Statistical Analysis Used: The data were analyzed using SPSS 20 for Windows. Results: c-MET positivity which is considered by the score of 2+ and 3+ was found only in 34.4% of HER2 positive cases while it was 59.3% in HER2 negative cases (P = 0.045). The sole histopathological feature associated with c-MET positivity was distal gastric localization (P = 0.016). Conclusions: Even though higher rates of c-MET positivity in HER2 positive cases were stated in the literature, contrary results were obtained in this study. Comparing the HER2+/c-MET + co-expression group with the other groups, no difference was found about age, sex, macroscopic and microscopic characteristics. The presence of c-MET positivity in cases with HER2 expression suggests that c-MET expression might be associated with the resistance to Trastuzumab. |
| first_indexed | 2024-04-11T01:29:48Z |
| format | Article |
| id | doaj.art-d7553477b5ad487c8ceb7da9fe3d0293 |
| institution | Directory Open Access Journal |
| issn | 0377-4929 |
| language | English |
| last_indexed | 2024-04-11T01:29:48Z |
| publishDate | 2022-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Indian Journal of Pathology and Microbiology |
| spelling | doaj.art-d7553477b5ad487c8ceb7da9fe3d02932023-01-03T09:56:32ZengWolters Kluwer Medknow PublicationsIndian Journal of Pathology and Microbiology0377-49292022-01-0165478679010.4103/ijpm.ijpm_23_21c-MET positivity and its relationship with histopathological findings in gastric carcinomas exhibiting HER2 gene expressionFerhat CoskunSemin AyhanAyca TanAydin IsisagContext: Co-expressions of receptor tyrosine kinases such as c-MET and HER2 were reported in many studies. The concomitant expression is associated with more aggressive clinical course. Aims: In this study, it was intended to investigate the correlation of the positivity of c-MET and HER2 with histopathologic findings and their impacts on prognosis. Subjects and Methods: After the decision of the ethics committee, a total of 64 cases, whose HER 2 status was studied by dual silver in situ hybridization/immunohistochemistry method, were included in the study. Immunohistochemical staining for c-MET was performed to all cases and the evaluation was performed similarly to the criteria for HER2 evaluation, but cytoplasmic staining was also considered significant. Statistical Analysis Used: The data were analyzed using SPSS 20 for Windows. Results: c-MET positivity which is considered by the score of 2+ and 3+ was found only in 34.4% of HER2 positive cases while it was 59.3% in HER2 negative cases (P = 0.045). The sole histopathological feature associated with c-MET positivity was distal gastric localization (P = 0.016). Conclusions: Even though higher rates of c-MET positivity in HER2 positive cases were stated in the literature, contrary results were obtained in this study. Comparing the HER2+/c-MET + co-expression group with the other groups, no difference was found about age, sex, macroscopic and microscopic characteristics. The presence of c-MET positivity in cases with HER2 expression suggests that c-MET expression might be associated with the resistance to Trastuzumab.http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2022;volume=65;issue=4;spage=786;epage=790;aulast=Coskunc-metdual sish/ihcgastric carcinomaher2immunohistochemistryin situ hybridization |
| spellingShingle | Ferhat Coskun Semin Ayhan Ayca Tan Aydin Isisag c-MET positivity and its relationship with histopathological findings in gastric carcinomas exhibiting HER2 gene expression Indian Journal of Pathology and Microbiology c-met dual sish/ihc gastric carcinoma her2 immunohistochemistry in situ hybridization |
| title | c-MET positivity and its relationship with histopathological findings in gastric carcinomas exhibiting HER2 gene expression |
| title_full | c-MET positivity and its relationship with histopathological findings in gastric carcinomas exhibiting HER2 gene expression |
| title_fullStr | c-MET positivity and its relationship with histopathological findings in gastric carcinomas exhibiting HER2 gene expression |
| title_full_unstemmed | c-MET positivity and its relationship with histopathological findings in gastric carcinomas exhibiting HER2 gene expression |
| title_short | c-MET positivity and its relationship with histopathological findings in gastric carcinomas exhibiting HER2 gene expression |
| title_sort | c met positivity and its relationship with histopathological findings in gastric carcinomas exhibiting her2 gene expression |
| topic | c-met dual sish/ihc gastric carcinoma her2 immunohistochemistry in situ hybridization |
| url | http://www.ijpmonline.org/article.asp?issn=0377-4929;year=2022;volume=65;issue=4;spage=786;epage=790;aulast=Coskun |
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