Sleep pattern, healthy lifestyle and colorectal cancer incidence
Abstract Researchers have identified an association between lifestyle factors and colorectal cancer (CRC) risk. This study examined the relationship between sleep patterns and CRC events. 392,252 individuals were sampled from the UK Biobank. Chronotype, sleep duration, insomnia, snoring, and excessi...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-10-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-022-21879-w |
| _version_ | 1811233762470526976 |
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| author | Jie Chen Nanqian Chen Tao Huang Ninghao Huang Zhenhuang Zhuang Hailun Liang |
| author_facet | Jie Chen Nanqian Chen Tao Huang Ninghao Huang Zhenhuang Zhuang Hailun Liang |
| author_sort | Jie Chen |
| collection | DOAJ |
| description | Abstract Researchers have identified an association between lifestyle factors and colorectal cancer (CRC) risk. This study examined the relationship between sleep patterns and CRC events. 392,252 individuals were sampled from the UK Biobank. Chronotype, sleep duration, insomnia, snoring, and excessive daytime sleepiness were combined to measure a healthy sleep score. A number of healthy sleep factors were defined, along with factors for healthy lifestyle scores. Using Cox proportional hazards regression, computed hazard ratios (HRs) were used to examine the associations between sleep patterns, healthy lifestyles, and the incidence of CRC. Healthy sleep scores were inversely associated with CRC events. The HRs for CRC were 0.90 (95% CI, 0.88–0.92) and 0.95 (95% CI, 0.92–0.98) for a 1-point healthy sleep score increase among males and females. When analyzing sleep components, sleeping 7–8 h/day, no frequent insomnia, no snoring, and no frequent daytime sleepiness were independently associated with a 9%, 14%, 8%, and 14% lower risk of CRC, respectively, whilst healthy lifestyle scores were inversely associated with CRC incidence across all models. Sleep pattern and lifestyle are significantly correlated with CRC risk. The healthier the subject’s lifestyle and sleep pattern, the lower their CRC risk. |
| first_indexed | 2024-04-12T11:24:44Z |
| format | Article |
| id | doaj.art-d7579bf6bfeb482993809da20fa9aa64 |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-12T11:24:44Z |
| publishDate | 2022-10-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-d7579bf6bfeb482993809da20fa9aa642022-12-22T03:35:15ZengNature PortfolioScientific Reports2045-23222022-10-0112111010.1038/s41598-022-21879-wSleep pattern, healthy lifestyle and colorectal cancer incidenceJie Chen0Nanqian Chen1Tao Huang2Ninghao Huang3Zhenhuang Zhuang4Hailun Liang5School of Public Administration and Policy, Renmin University of ChinaSchool of Public Administration and Policy, Renmin University of ChinaDepartment of Epidemiology and Biostatistics, School of Public Health, Peking UniversityDepartment of Epidemiology and Biostatistics, School of Public Health, Peking UniversityDepartment of Epidemiology and Biostatistics, School of Public Health, Peking UniversitySchool of Public Administration and Policy, Renmin University of ChinaAbstract Researchers have identified an association between lifestyle factors and colorectal cancer (CRC) risk. This study examined the relationship between sleep patterns and CRC events. 392,252 individuals were sampled from the UK Biobank. Chronotype, sleep duration, insomnia, snoring, and excessive daytime sleepiness were combined to measure a healthy sleep score. A number of healthy sleep factors were defined, along with factors for healthy lifestyle scores. Using Cox proportional hazards regression, computed hazard ratios (HRs) were used to examine the associations between sleep patterns, healthy lifestyles, and the incidence of CRC. Healthy sleep scores were inversely associated with CRC events. The HRs for CRC were 0.90 (95% CI, 0.88–0.92) and 0.95 (95% CI, 0.92–0.98) for a 1-point healthy sleep score increase among males and females. When analyzing sleep components, sleeping 7–8 h/day, no frequent insomnia, no snoring, and no frequent daytime sleepiness were independently associated with a 9%, 14%, 8%, and 14% lower risk of CRC, respectively, whilst healthy lifestyle scores were inversely associated with CRC incidence across all models. Sleep pattern and lifestyle are significantly correlated with CRC risk. The healthier the subject’s lifestyle and sleep pattern, the lower their CRC risk.https://doi.org/10.1038/s41598-022-21879-w |
| spellingShingle | Jie Chen Nanqian Chen Tao Huang Ninghao Huang Zhenhuang Zhuang Hailun Liang Sleep pattern, healthy lifestyle and colorectal cancer incidence Scientific Reports |
| title | Sleep pattern, healthy lifestyle and colorectal cancer incidence |
| title_full | Sleep pattern, healthy lifestyle and colorectal cancer incidence |
| title_fullStr | Sleep pattern, healthy lifestyle and colorectal cancer incidence |
| title_full_unstemmed | Sleep pattern, healthy lifestyle and colorectal cancer incidence |
| title_short | Sleep pattern, healthy lifestyle and colorectal cancer incidence |
| title_sort | sleep pattern healthy lifestyle and colorectal cancer incidence |
| url | https://doi.org/10.1038/s41598-022-21879-w |
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