Association Between Mean Platelet Volume and Benign Prostatic Hyperplasia: A Population Study from the TCLSIH Cohort Study
Yanqi Song,1 Yeqing Gu,2 Honglei Guo,3 Honghao Yang,4– 6 Xuena Wang,4– 6 Hongmei Wu,4– 6 Aidi Wang,1 Mengxiao Wang,7 Haijin Wang,1 Qing Zhang,8 Li Liu,8 Ge Meng,6,8– 10 Baoshan Liu,1 Kaijun Niu4– 6 1Department of Traditional Chinese Medicine, Tianjin Medical University General Hospital, Tianjin, Peo...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Dove Medical Press
2023-08-01
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| Series: | Journal of Inflammation Research |
| Subjects: | |
| Online Access: | https://www.dovepress.com/association-between-mean-platelet-volume-and-benign-prostatic-hyperpla-peer-reviewed-fulltext-article-JIR |
| _version_ | 1797752584831762432 |
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| author | Song Y Gu Y Guo H Yang H Wang X Wu H Wang A Wang M Wang H Zhang Q Liu L Meng G Liu B Niu K |
| author_facet | Song Y Gu Y Guo H Yang H Wang X Wu H Wang A Wang M Wang H Zhang Q Liu L Meng G Liu B Niu K |
| author_sort | Song Y |
| collection | DOAJ |
| description | Yanqi Song,1 Yeqing Gu,2 Honglei Guo,3 Honghao Yang,4– 6 Xuena Wang,4– 6 Hongmei Wu,4– 6 Aidi Wang,1 Mengxiao Wang,7 Haijin Wang,1 Qing Zhang,8 Li Liu,8 Ge Meng,6,8– 10 Baoshan Liu,1 Kaijun Niu4– 6 1Department of Traditional Chinese Medicine, Tianjin Medical University General Hospital, Tianjin, People’s Republic of China; 2Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, People’s Republic of China; 3Tianjin University of Traditional Chinese Medicine, Tianjin, People’s Republic of China; 4School of Public Health of Tianjin University of Traditional Chinese Medicine, Tianjin, People’s Republic of China; 5School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, People’s Republic of China; 6Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, People’s Republic of China; 7Binzhou Hospital of Chinese Medicine, Shandong, People’s Republic of China; 8Health Management Centre, Tianjin Medical University General Hospital, Tianjin, People’s Republic of China; 9Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin, People’s Republic of China; 10Department of Toxicology and Sanitary Chemistry, School of Public Health, Tianjin Medical University, Tianjin, People’s Republic of ChinaCorrespondence: Kaijun Niu; Baoshan Liu, Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, 22 Qixiangtai Road, Heping District, Tianjin, 300070, People’s Republic of China, Tel +86-22-83336613, Email nkj0809@gmail.com; niukaijun@tmu.edu.cn; lbs-cd@163.comPurpose: This study aimed to prospectively investigate the association between mean platelet volume (MPV) levels and risk of benign prostatic hyperplasia (BPH) in a general Chinese adult male population, and assessed this association in metabolic syndrome (MetS) patients.Patients and methods: This study included a total of 14,923 male participants free from BPH at baseline. MPV was measured by the method of laser-based flow cytometric impedance according to the complete blood sample. BPH was defined as total prostate volume (TPV) ≥ 30 mL, TPV was determined by transabdominal ultrasonography. Multivariable Cox proportional hazards models were fitted to calculate hazards ratios (HRs) and corresponding 95% confidence intervals (CIs) for BPH risk with NLR levels.Results: During a median follow-up of 2.7 years, 4848 BPH cases were documented in total male participants, and 1787 BPH cases were documented in MetS participants. After adjusting for age, body mass index, smoking, alcohol and personal and family history of disease, the multivariable-adjusted HRs of BPH were 1.00 (reference), 1.03 (95% CIs 0.96, 1.11), 1.00 (95% CIs 0.92, 1.08) and 0.98 (95% CIs 0.90, 1.06), respectively, for participants with MPV in the 1st, 2nd, 3rd and 4th quartiles (P for trend = 0.47). In MetS patients, the multivariable-adjusted HRs of BPH were 1.00 (reference), 1.03 (95% CIs 0.90, 1.16), 0.99 (95% CIs 0.87, 1.14) and 1.01 (95% CIs 0.89, 1.15) (P for trend= 0.98), respectively.Conclusion: A non-significant association was observed between MPV levels and risk of BPH, and no association in this association in MetS patients. Our findings support the notion that MPV levels may not be a target for BPH prevention and intervention.Keywords: mean platelet volume, inflammation, benign prostatic hyerplasia, metabolic syndrome, prospective cohort study |
| first_indexed | 2024-03-12T17:05:29Z |
| format | Article |
| id | doaj.art-d75b750797f3400cb12167893dd08cda |
| institution | Directory Open Access Journal |
| issn | 1178-7031 |
| language | English |
| last_indexed | 2024-03-12T17:05:29Z |
| publishDate | 2023-08-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Journal of Inflammation Research |
| spelling | doaj.art-d75b750797f3400cb12167893dd08cda2023-08-06T18:59:49ZengDove Medical PressJournal of Inflammation Research1178-70312023-08-01Volume 163259326985696Association Between Mean Platelet Volume and Benign Prostatic Hyperplasia: A Population Study from the TCLSIH Cohort StudySong YGu YGuo HYang HWang XWu HWang AWang MWang HZhang QLiu LMeng GLiu BNiu KYanqi Song,1 Yeqing Gu,2 Honglei Guo,3 Honghao Yang,4– 6 Xuena Wang,4– 6 Hongmei Wu,4– 6 Aidi Wang,1 Mengxiao Wang,7 Haijin Wang,1 Qing Zhang,8 Li Liu,8 Ge Meng,6,8– 10 Baoshan Liu,1 Kaijun Niu4– 6 1Department of Traditional Chinese Medicine, Tianjin Medical University General Hospital, Tianjin, People’s Republic of China; 2Institute of Radiation Medicine, Chinese Academy of Medical Sciences & Peking Union Medical College, Tianjin, People’s Republic of China; 3Tianjin University of Traditional Chinese Medicine, Tianjin, People’s Republic of China; 4School of Public Health of Tianjin University of Traditional Chinese Medicine, Tianjin, People’s Republic of China; 5School of Integrative Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, People’s Republic of China; 6Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, Tianjin, People’s Republic of China; 7Binzhou Hospital of Chinese Medicine, Shandong, People’s Republic of China; 8Health Management Centre, Tianjin Medical University General Hospital, Tianjin, People’s Republic of China; 9Tianjin Key Laboratory of Environment, Nutrition and Public Health, Tianjin, People’s Republic of China; 10Department of Toxicology and Sanitary Chemistry, School of Public Health, Tianjin Medical University, Tianjin, People’s Republic of ChinaCorrespondence: Kaijun Niu; Baoshan Liu, Nutritional Epidemiology Institute and School of Public Health, Tianjin Medical University, 22 Qixiangtai Road, Heping District, Tianjin, 300070, People’s Republic of China, Tel +86-22-83336613, Email nkj0809@gmail.com; niukaijun@tmu.edu.cn; lbs-cd@163.comPurpose: This study aimed to prospectively investigate the association between mean platelet volume (MPV) levels and risk of benign prostatic hyperplasia (BPH) in a general Chinese adult male population, and assessed this association in metabolic syndrome (MetS) patients.Patients and methods: This study included a total of 14,923 male participants free from BPH at baseline. MPV was measured by the method of laser-based flow cytometric impedance according to the complete blood sample. BPH was defined as total prostate volume (TPV) ≥ 30 mL, TPV was determined by transabdominal ultrasonography. Multivariable Cox proportional hazards models were fitted to calculate hazards ratios (HRs) and corresponding 95% confidence intervals (CIs) for BPH risk with NLR levels.Results: During a median follow-up of 2.7 years, 4848 BPH cases were documented in total male participants, and 1787 BPH cases were documented in MetS participants. After adjusting for age, body mass index, smoking, alcohol and personal and family history of disease, the multivariable-adjusted HRs of BPH were 1.00 (reference), 1.03 (95% CIs 0.96, 1.11), 1.00 (95% CIs 0.92, 1.08) and 0.98 (95% CIs 0.90, 1.06), respectively, for participants with MPV in the 1st, 2nd, 3rd and 4th quartiles (P for trend = 0.47). In MetS patients, the multivariable-adjusted HRs of BPH were 1.00 (reference), 1.03 (95% CIs 0.90, 1.16), 0.99 (95% CIs 0.87, 1.14) and 1.01 (95% CIs 0.89, 1.15) (P for trend= 0.98), respectively.Conclusion: A non-significant association was observed between MPV levels and risk of BPH, and no association in this association in MetS patients. Our findings support the notion that MPV levels may not be a target for BPH prevention and intervention.Keywords: mean platelet volume, inflammation, benign prostatic hyerplasia, metabolic syndrome, prospective cohort studyhttps://www.dovepress.com/association-between-mean-platelet-volume-and-benign-prostatic-hyperpla-peer-reviewed-fulltext-article-JIRmean platelet volumeinflammationbenign prostatic hyperplasiametabolic syndromeprospective cohort study |
| spellingShingle | Song Y Gu Y Guo H Yang H Wang X Wu H Wang A Wang M Wang H Zhang Q Liu L Meng G Liu B Niu K Association Between Mean Platelet Volume and Benign Prostatic Hyperplasia: A Population Study from the TCLSIH Cohort Study Journal of Inflammation Research mean platelet volume inflammation benign prostatic hyperplasia metabolic syndrome prospective cohort study |
| title | Association Between Mean Platelet Volume and Benign Prostatic Hyperplasia: A Population Study from the TCLSIH Cohort Study |
| title_full | Association Between Mean Platelet Volume and Benign Prostatic Hyperplasia: A Population Study from the TCLSIH Cohort Study |
| title_fullStr | Association Between Mean Platelet Volume and Benign Prostatic Hyperplasia: A Population Study from the TCLSIH Cohort Study |
| title_full_unstemmed | Association Between Mean Platelet Volume and Benign Prostatic Hyperplasia: A Population Study from the TCLSIH Cohort Study |
| title_short | Association Between Mean Platelet Volume and Benign Prostatic Hyperplasia: A Population Study from the TCLSIH Cohort Study |
| title_sort | association between mean platelet volume and benign prostatic hyperplasia a population study from the tclsih cohort study |
| topic | mean platelet volume inflammation benign prostatic hyperplasia metabolic syndrome prospective cohort study |
| url | https://www.dovepress.com/association-between-mean-platelet-volume-and-benign-prostatic-hyperpla-peer-reviewed-fulltext-article-JIR |
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