Comparison of Clonidine versus Esmolol in Controlled Hypotension in Patients Undergoing FESS Surgery
Background: FESS has its share of complications which can be a challenge for both the surgeon as well the anesthetist and achieving a bloodless surgical field is essential So the principle of controlled hypotension can be used to combat this issue. Methods: A hospital-based randomized comparative i...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Tehran University of Medical Sciences
2023-10-01
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| Series: | Archives of Anesthesia and Critical Care |
| Subjects: | |
| Online Access: | https://aacc.tums.ac.ir/index.php/aacc/article/view/729 |
| _version_ | 1797304030901305344 |
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| author | Komal Garg Samridhi Nanda Usha Bafna Chandan Bala Mali Sumaila Naaz Nelwin Jerald Sabu |
| author_facet | Komal Garg Samridhi Nanda Usha Bafna Chandan Bala Mali Sumaila Naaz Nelwin Jerald Sabu |
| author_sort | Komal Garg |
| collection | DOAJ |
| description |
Background: FESS has its share of complications which can be a challenge for both the surgeon as well the anesthetist and achieving a bloodless surgical field is essential So the principle of controlled hypotension can be used to combat this issue.
Methods: A hospital-based randomized comparative interventional study was conducted on 60 patients to compare Clonidine (2mcg/kg in 10 ml of saline over 10 minutes before induction followed by an infusion of 1mcg/kg/hr during maintenance) and Esmolol (1mg/kg in 10 ml of saline over 10 minutes before induction followed by an infusion of 1mg/kg/hr during maintenance) to assess and compare the hypotensive properties of both the drugs.
Results: After the induction of anesthesia, there was a significant difference in the mean heart rate, and mean arterial pressure between the two groups throughout the intraoperative period (p-value < 0.05). Both groups achieved a target mean arterial pressure (MAP) of 65-70 mmHg and improved surgical field quality.
Conclusion: This study concluded that clonidine and esmolol both provide hemodynamic stability and a better surgical field in functional endoscopic sinus surgery (FESS). Clonidine also helps in achieving postoperative sedation and analgesia.
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| first_indexed | 2024-03-08T00:02:27Z |
| format | Article |
| id | doaj.art-d75d3ab11a944bfc9a7679ae5ff49c47 |
| institution | Directory Open Access Journal |
| issn | 2423-5849 |
| language | English |
| last_indexed | 2024-03-08T00:02:27Z |
| publishDate | 2023-10-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Archives of Anesthesia and Critical Care |
| spelling | doaj.art-d75d3ab11a944bfc9a7679ae5ff49c472024-02-18T03:52:21ZengTehran University of Medical SciencesArchives of Anesthesia and Critical Care2423-58492023-10-0110110.18502/aacc.v10i1.14765Comparison of Clonidine versus Esmolol in Controlled Hypotension in Patients Undergoing FESS SurgeryKomal Garg0Samridhi Nanda1Usha Bafna2Chandan Bala Mali3Sumaila Naaz4Nelwin Jerald Sabu5Department of Anaesthesia, SMS Medical College and Hospital, Rajasthan University of Health Sciences, Jaipur, India.Department of Anaesthesia, SMS Medical College and Hospital, Rajasthan University of Health Sciences, Jaipur, India.Department of Anaesthesia, SMS Medical College and Hospital, Rajasthan University of Health Sciences, Jaipur, India.Department of Anaesthesia, SMS Medical College and Hospital, Rajasthan University of Health Sciences, Jaipur, India.Department of Anaesthesia, SMS Medical College and Hospital, Rajasthan University of Health Sciences, Jaipur, India.Department of Anaesthesia, SMS Medical College and Hospital, Rajasthan University of Health Sciences, Jaipur, India. Background: FESS has its share of complications which can be a challenge for both the surgeon as well the anesthetist and achieving a bloodless surgical field is essential So the principle of controlled hypotension can be used to combat this issue. Methods: A hospital-based randomized comparative interventional study was conducted on 60 patients to compare Clonidine (2mcg/kg in 10 ml of saline over 10 minutes before induction followed by an infusion of 1mcg/kg/hr during maintenance) and Esmolol (1mg/kg in 10 ml of saline over 10 minutes before induction followed by an infusion of 1mg/kg/hr during maintenance) to assess and compare the hypotensive properties of both the drugs. Results: After the induction of anesthesia, there was a significant difference in the mean heart rate, and mean arterial pressure between the two groups throughout the intraoperative period (p-value < 0.05). Both groups achieved a target mean arterial pressure (MAP) of 65-70 mmHg and improved surgical field quality. Conclusion: This study concluded that clonidine and esmolol both provide hemodynamic stability and a better surgical field in functional endoscopic sinus surgery (FESS). Clonidine also helps in achieving postoperative sedation and analgesia. https://aacc.tums.ac.ir/index.php/aacc/article/view/729Controlled hypotensionClonidineEsmolol |
| spellingShingle | Komal Garg Samridhi Nanda Usha Bafna Chandan Bala Mali Sumaila Naaz Nelwin Jerald Sabu Comparison of Clonidine versus Esmolol in Controlled Hypotension in Patients Undergoing FESS Surgery Archives of Anesthesia and Critical Care Controlled hypotension Clonidine Esmolol |
| title | Comparison of Clonidine versus Esmolol in Controlled Hypotension in Patients Undergoing FESS Surgery |
| title_full | Comparison of Clonidine versus Esmolol in Controlled Hypotension in Patients Undergoing FESS Surgery |
| title_fullStr | Comparison of Clonidine versus Esmolol in Controlled Hypotension in Patients Undergoing FESS Surgery |
| title_full_unstemmed | Comparison of Clonidine versus Esmolol in Controlled Hypotension in Patients Undergoing FESS Surgery |
| title_short | Comparison of Clonidine versus Esmolol in Controlled Hypotension in Patients Undergoing FESS Surgery |
| title_sort | comparison of clonidine versus esmolol in controlled hypotension in patients undergoing fess surgery |
| topic | Controlled hypotension Clonidine Esmolol |
| url | https://aacc.tums.ac.ir/index.php/aacc/article/view/729 |
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