Proteomics and metabolomics analyses of camptothecin-producing Aspergillus terreus reveal the integration of PH domain-containing proteins and peptidylprolyl cis/trans isomerase in restoring the camptothecin biosynthesis

Proteomics and metabolomics analyses of camptothecin-producing Aspergillus terreus reveal the integration of PH domain-containing proteins and peptidylprolyl cis/trans isomerase in restoring the camptothecin biosynthesis

ABSTRACT Attenuating the expression of fungal camptothecin biosynthetic genes with subculturing is the challenge that halts their further implementation. The camptothecin productivity of the subcultured Aspergillus terreus has been restored upon addition of Ficus elastica indigenous microbiome; howe...

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Bibliographic Details
Main Authors: Amgad M. Rady, Ashraf S. A. El-Sayed, Ashraf F. El-Baz, Ghada G. Abdel-Fattah, Sameh Magdeldin, Eman Ahmed, Aya Osama, Sameh E. Hassanein, Hend Saed, Marwa Yassin
Format: Article
Language:English
Published: American Society for Microbiology 2023-12-01
Series:Microbiology Spectrum
Subjects:
camptothecin
Aspergillus terreus
proteomics analysis
metabolomics analysis
Online Access:https://journals.asm.org/doi/10.1128/spectrum.02281-23

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