Identifying Modulated Functional Connectivity in Corresponding Cerebral Networks in Facial Nerve Lesions Patients With Facial Asymmetry
Facial asymmetry is the major complaint of patients with unilateral facial nerve lesions. Frustratingly, although patients experience the same etiology, the extent of oral commissure asymmetry is highly heterogeneous. Emerging evidence indicates that cerebral plasticity has a large impact on clinica...
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2022-06-01
|
| Series: | Frontiers in Neuroscience |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fnins.2022.943919/full |
| _version_ | 1811238599751892992 |
|---|---|
| author | Hao Ma Yu-lu Zhou Wen-jin Wang Gang Chen Qing Li Ye-chen Lu Wei Wang |
| author_facet | Hao Ma Yu-lu Zhou Wen-jin Wang Gang Chen Qing Li Ye-chen Lu Wei Wang |
| author_sort | Hao Ma |
| collection | DOAJ |
| description | Facial asymmetry is the major complaint of patients with unilateral facial nerve lesions. Frustratingly, although patients experience the same etiology, the extent of oral commissure asymmetry is highly heterogeneous. Emerging evidence indicates that cerebral plasticity has a large impact on clinical severity by promoting or impeding the progressive adaption of brain function. However, the precise link between cerebral plasticity and oral asymmetry has not yet been identified. In the present study, we performed functional magnetic resonance imaging on patients with unilateral facial nerve transections to acquire in vivo neural activity. We then identified the regions of interest corresponding to oral movement control using a smiling motor paradigm. Next, we established three local networks: the ipsilesional (left) intrahemispheric, contralesional (right) intrahemispheric, and interhemispheric networks. The functional connectivity of each pair of nodes within each network was then calculated. After thresholding for sparsity, we analyzed the mean intensity of each network connection between patients and controls by averaging the functional connectivity. For the objective assessment of facial deflection, oral asymmetry was calculated using FACEgram software. There was decreased connectivity in the contralesional network but increased connectivity in the ipsilesional and interhemispheric networks in patients with facial nerve lesions. In addition, connectivity in the ipsilesional network was significantly correlated with the extent of oral asymmetry. Our results suggest that motor deafferentation of unilateral facial nerve leads to the upregulated ipsilesional hemispheric connections, and results in positive interhemispheric inhibition effects to the contralesional hemisphere. Our findings provide preliminary information about the possible cortical etiology of facial asymmetry, and deliver valuable clues regarding spatial information, which will likely be useful for the development of therapeutic interventions. |
| first_indexed | 2024-04-12T12:45:27Z |
| format | Article |
| id | doaj.art-d75fa6ad06404dd594ebf9f7ffee8f85 |
| institution | Directory Open Access Journal |
| issn | 1662-453X |
| language | English |
| last_indexed | 2024-04-12T12:45:27Z |
| publishDate | 2022-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Neuroscience |
| spelling | doaj.art-d75fa6ad06404dd594ebf9f7ffee8f852022-12-22T03:32:39ZengFrontiers Media S.A.Frontiers in Neuroscience1662-453X2022-06-011610.3389/fnins.2022.943919943919Identifying Modulated Functional Connectivity in Corresponding Cerebral Networks in Facial Nerve Lesions Patients With Facial AsymmetryHao Ma0Yu-lu Zhou1Wen-jin Wang2Gang Chen3Qing Li4Ye-chen Lu5Wei Wang6Department of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaMR Collaborations, Siemens Healthineers Ltd., Shanghai, ChinaWound Healing Center, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaDepartment of Plastic and Reconstructive Surgery, Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, ChinaFacial asymmetry is the major complaint of patients with unilateral facial nerve lesions. Frustratingly, although patients experience the same etiology, the extent of oral commissure asymmetry is highly heterogeneous. Emerging evidence indicates that cerebral plasticity has a large impact on clinical severity by promoting or impeding the progressive adaption of brain function. However, the precise link between cerebral plasticity and oral asymmetry has not yet been identified. In the present study, we performed functional magnetic resonance imaging on patients with unilateral facial nerve transections to acquire in vivo neural activity. We then identified the regions of interest corresponding to oral movement control using a smiling motor paradigm. Next, we established three local networks: the ipsilesional (left) intrahemispheric, contralesional (right) intrahemispheric, and interhemispheric networks. The functional connectivity of each pair of nodes within each network was then calculated. After thresholding for sparsity, we analyzed the mean intensity of each network connection between patients and controls by averaging the functional connectivity. For the objective assessment of facial deflection, oral asymmetry was calculated using FACEgram software. There was decreased connectivity in the contralesional network but increased connectivity in the ipsilesional and interhemispheric networks in patients with facial nerve lesions. In addition, connectivity in the ipsilesional network was significantly correlated with the extent of oral asymmetry. Our results suggest that motor deafferentation of unilateral facial nerve leads to the upregulated ipsilesional hemispheric connections, and results in positive interhemispheric inhibition effects to the contralesional hemisphere. Our findings provide preliminary information about the possible cortical etiology of facial asymmetry, and deliver valuable clues regarding spatial information, which will likely be useful for the development of therapeutic interventions.https://www.frontiersin.org/articles/10.3389/fnins.2022.943919/fullfacial nervecerebral plasticityfacial asymmetryfunctional connectivityinterhemispheric inhibitionfMRI |
| spellingShingle | Hao Ma Yu-lu Zhou Wen-jin Wang Gang Chen Qing Li Ye-chen Lu Wei Wang Identifying Modulated Functional Connectivity in Corresponding Cerebral Networks in Facial Nerve Lesions Patients With Facial Asymmetry Frontiers in Neuroscience facial nerve cerebral plasticity facial asymmetry functional connectivity interhemispheric inhibition fMRI |
| title | Identifying Modulated Functional Connectivity in Corresponding Cerebral Networks in Facial Nerve Lesions Patients With Facial Asymmetry |
| title_full | Identifying Modulated Functional Connectivity in Corresponding Cerebral Networks in Facial Nerve Lesions Patients With Facial Asymmetry |
| title_fullStr | Identifying Modulated Functional Connectivity in Corresponding Cerebral Networks in Facial Nerve Lesions Patients With Facial Asymmetry |
| title_full_unstemmed | Identifying Modulated Functional Connectivity in Corresponding Cerebral Networks in Facial Nerve Lesions Patients With Facial Asymmetry |
| title_short | Identifying Modulated Functional Connectivity in Corresponding Cerebral Networks in Facial Nerve Lesions Patients With Facial Asymmetry |
| title_sort | identifying modulated functional connectivity in corresponding cerebral networks in facial nerve lesions patients with facial asymmetry |
| topic | facial nerve cerebral plasticity facial asymmetry functional connectivity interhemispheric inhibition fMRI |
| url | https://www.frontiersin.org/articles/10.3389/fnins.2022.943919/full |
| work_keys_str_mv | AT haoma identifyingmodulatedfunctionalconnectivityincorrespondingcerebralnetworksinfacialnervelesionspatientswithfacialasymmetry AT yuluzhou identifyingmodulatedfunctionalconnectivityincorrespondingcerebralnetworksinfacialnervelesionspatientswithfacialasymmetry AT wenjinwang identifyingmodulatedfunctionalconnectivityincorrespondingcerebralnetworksinfacialnervelesionspatientswithfacialasymmetry AT gangchen identifyingmodulatedfunctionalconnectivityincorrespondingcerebralnetworksinfacialnervelesionspatientswithfacialasymmetry AT qingli identifyingmodulatedfunctionalconnectivityincorrespondingcerebralnetworksinfacialnervelesionspatientswithfacialasymmetry AT yechenlu identifyingmodulatedfunctionalconnectivityincorrespondingcerebralnetworksinfacialnervelesionspatientswithfacialasymmetry AT weiwang identifyingmodulatedfunctionalconnectivityincorrespondingcerebralnetworksinfacialnervelesionspatientswithfacialasymmetry |