Gliflozins Have an Anti-Inflammatory Effect on Renal Proximal Tubular Epithelial Cells in a Diabetic and Inflammatory Microenvironment In Vitro

Gliflozins Have an Anti-Inflammatory Effect on Renal Proximal Tubular Epithelial Cells in a Diabetic and Inflammatory Microenvironment In Vitro

Inflammation is intimately involved in the pathogenesis of diabetic kidney disease. Inhibition of SGLT-2 by a specific class of drugs, gliflozins, has been shown to reduce inflammation and attenuate the progression of diabetic nephropathy, in addition to its main effect of inhibiting renal glucose r...

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Bibliographic Details
Main Authors: Benjamin Koch, Dominik C. Fuhrmann, Ralf Schubert, Helmut Geiger, Thimoteus Speer, Patrick C. Baer
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:International Journal of Molecular Sciences
Subjects:
renal tubular cells
epithelial cells
proximal tubule
cytokines
inflammation
empagliflozin
Online Access:https://www.mdpi.com/1422-0067/24/3/1811

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