Driving forces behind phase separation of the carboxy-terminal domain of RNA polymerase II

Driving forces behind phase separation of the carboxy-terminal domain of RNA polymerase II

Abstract Eukaryotic gene regulation and pre-mRNA transcription depend on the carboxy-terminal domain (CTD) of RNA polymerase (Pol) II. Due to its highly repetitive, intrinsically disordered sequence, the CTD enables clustering and phase separation of Pol II. The molecular interactions that drive CTD...

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Bibliographic Details
Main Authors: David Flores-Solis, Irina P. Lushpinskaia, Anton A. Polyansky, Arya Changiarath, Marc Boehning, Milana Mirkovic, James Walshe, Lisa M. Pietrek, Patrick Cramer, Lukas S. Stelzl, Bojan Zagrovic, Markus Zweckstetter
Format: Article
Language:English
Published: Nature Portfolio 2023-09-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-41633-8

Internet

https://doi.org/10.1038/s41467-023-41633-8

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