Morphological and functional assessment of the effect of L-lysine aescinat in rats with experimental ischemia of the spinal cord
Background.Spinal cord ischemia (SCI) is accompanied by severepersistent neurological and physical disorders. The articlediscusses potential neuroprotective effect of L-lysine aescinat. Objective.to assess the effect of L-lysine aescinat on the functionalrecovery and morphological picture of spinal...
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| Format: | Article |
| Language: | English |
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Research Center of Neurology
2017-02-01
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| Series: | Анналы клинической и экспериментальной неврологии |
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| Online Access: | https://annaly-nevrologii.com/journal/pathID/article/viewFile/46/107 |
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| author | G. V. Ponomarev A. A. Shmonin A. G. Shumeeva K. T. Aliyev T. D. Vlasov E. V. Mel’nikova A. A. Skoromets |
| author_facet | G. V. Ponomarev A. A. Shmonin A. G. Shumeeva K. T. Aliyev T. D. Vlasov E. V. Mel’nikova A. A. Skoromets |
| author_sort | G. V. Ponomarev |
| collection | DOAJ |
| description | Background.Spinal cord ischemia (SCI) is accompanied by severepersistent neurological and physical disorders. The articlediscusses potential neuroprotective effect of L-lysine aescinat.
Objective.to assess the effect of L-lysine aescinat on the functionalrecovery and morphological picture of spinal cord in whiterats with simulated SCI.
Methods. Spinal cord ischemia was induced by ligation of the infrarenalabdominal aorta in two experimental groups of rats. Inthe control group (n=8), aorta was ligated; in the experimentalgroup (n=8), L-lysine aescinat was injected intraperitoneally ata dose of 0.14 mg/kg 30 minutes before ischemia, followed byligation of aorta.
Results.Pronounced and statistically significant neuroprotectiveeffect of L-lysine aescinat was demonstrated, which clinicallymanifested as neurological deficit reduction and morphologicallymanifested as increased number of normochromic neurons and decreasednumber of shrunken neurons and shadow-cells (p0.01), aswell as suppression of edema of the spinal cord substance.
Conclusion.L-lysine aescinat has a neuroprotective effect in ratswith experimental ischemia of the spinal cord. |
| first_indexed | 2024-12-12T10:37:40Z |
| format | Article |
| id | doaj.art-d7672c0155374df08b3db0e34dae20f6 |
| institution | Directory Open Access Journal |
| issn | 2075-5473 2409-2533 |
| language | English |
| last_indexed | 2024-12-12T10:37:40Z |
| publishDate | 2017-02-01 |
| publisher | Research Center of Neurology |
| record_format | Article |
| series | Анналы клинической и экспериментальной неврологии |
| spelling | doaj.art-d7672c0155374df08b3db0e34dae20f62022-12-22T00:27:09ZengResearch Center of NeurologyАнналы клинической и экспериментальной неврологии2075-54732409-25332017-02-01103404410.17816/psaic4620Morphological and functional assessment of the effect of L-lysine aescinat in rats with experimental ischemia of the spinal cordG. V. Ponomarev0A. A. Shmonin1A. G. Shumeeva2K. T. Aliyev3T. D. Vlasov4E. V. Mel’nikova5A. A. Skoromets6I.P. Pavlov First Saint-Petersburg State Medical University, Ministry of Health of the Russian Federation, St. PetersburgI.P. Pavlov First Saint-Petersburg State Medical University, Ministry of Health of the Russian Federation, St. PetersburgI.P. Pavlov First Saint-Petersburg State Medical University, Ministry of Health of the Russian Federation, St. PetersburgI.P. Pavlov First Saint-Petersburg State Medical University, Ministry of Health of the Russian Federation, St. PetersburgI.P. Pavlov First Saint-Petersburg State Medical University, Ministry of Health of the Russian Federation, St. PetersburgГБОУ ВПО «Первый Санкт-Петербургский государственный медицинский университет им. акад. И.П. Павлова» Минздрава РоссииV.A. Almazov North-West Federal Medical Research Center, Ministry of Health of the Russian Federation, St. PetersburgBackground.Spinal cord ischemia (SCI) is accompanied by severepersistent neurological and physical disorders. The articlediscusses potential neuroprotective effect of L-lysine aescinat. Objective.to assess the effect of L-lysine aescinat on the functionalrecovery and morphological picture of spinal cord in whiterats with simulated SCI. Methods. Spinal cord ischemia was induced by ligation of the infrarenalabdominal aorta in two experimental groups of rats. Inthe control group (n=8), aorta was ligated; in the experimentalgroup (n=8), L-lysine aescinat was injected intraperitoneally ata dose of 0.14 mg/kg 30 minutes before ischemia, followed byligation of aorta. Results.Pronounced and statistically significant neuroprotectiveeffect of L-lysine aescinat was demonstrated, which clinicallymanifested as neurological deficit reduction and morphologicallymanifested as increased number of normochromic neurons and decreasednumber of shrunken neurons and shadow-cells (p0.01), aswell as suppression of edema of the spinal cord substance. Conclusion.L-lysine aescinat has a neuroprotective effect in ratswith experimental ischemia of the spinal cord.https://annaly-nevrologii.com/journal/pathID/article/viewFile/46/107spinal cordischemiamodelneuronsl-lysine aescinat |
| spellingShingle | G. V. Ponomarev A. A. Shmonin A. G. Shumeeva K. T. Aliyev T. D. Vlasov E. V. Mel’nikova A. A. Skoromets Morphological and functional assessment of the effect of L-lysine aescinat in rats with experimental ischemia of the spinal cord Анналы клинической и экспериментальной неврологии spinal cord ischemia model neurons l-lysine aescinat |
| title | Morphological and functional assessment of the effect of L-lysine aescinat in rats with experimental ischemia of the spinal cord |
| title_full | Morphological and functional assessment of the effect of L-lysine aescinat in rats with experimental ischemia of the spinal cord |
| title_fullStr | Morphological and functional assessment of the effect of L-lysine aescinat in rats with experimental ischemia of the spinal cord |
| title_full_unstemmed | Morphological and functional assessment of the effect of L-lysine aescinat in rats with experimental ischemia of the spinal cord |
| title_short | Morphological and functional assessment of the effect of L-lysine aescinat in rats with experimental ischemia of the spinal cord |
| title_sort | morphological and functional assessment of the effect of l lysine aescinat in rats with experimental ischemia of the spinal cord |
| topic | spinal cord ischemia model neurons l-lysine aescinat |
| url | https://annaly-nevrologii.com/journal/pathID/article/viewFile/46/107 |
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