Recurrent sideroblastic anemia during pregnancy
Abstract Sideroblastic anemia is a heterogeneous group of disorders typified by the presence of ring sideroblasts in the bone marrow and has congenital and acquired types. Sideroblastic anemia is a rare event in pregnancy. We report a case of a 32‐year‐old female patient, gravida 4 para 3, 27th week...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-01-01
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| Series: | Clinical Case Reports |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/ccr3.6814 |
| _version_ | 1811162535099891712 |
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| author | Shehab Mohamed Firyal Ibrahim Mohamad Najib Alasafar Awni Alshurafa Susanna Akiki Dina Soliman Samah Kohla Aliaa Amer Hana Qasim Honar Cherif |
| author_facet | Shehab Mohamed Firyal Ibrahim Mohamad Najib Alasafar Awni Alshurafa Susanna Akiki Dina Soliman Samah Kohla Aliaa Amer Hana Qasim Honar Cherif |
| author_sort | Shehab Mohamed |
| collection | DOAJ |
| description | Abstract Sideroblastic anemia is a heterogeneous group of disorders typified by the presence of ring sideroblasts in the bone marrow and has congenital and acquired types. Sideroblastic anemia is a rare event in pregnancy. We report a case of a 32‐year‐old female patient, gravida 4 para 3, 27th weeks pregnant, who presented to the emergency department complaining of palpitation and generalized weakness for 2 weeks. She was found to have severe normochromic normocytic anemia, with hemoglobin of 4.2 g/dl, and low reticulocytes count of 13 × 103/μl. She gave a history of recurrent anemia, which had only occurred during pregnancy. Her bone marrow aspirate showed many ring sideroblasts concluding the diagnosis of sideroblastic anemia (SA). Further investigation revealed a significantly low pyridoxine level (vitamin B6) of (8 nmol/L). The Hb level improved with vitamin B6 replacement, without any transfusion support. |
| first_indexed | 2024-04-10T06:31:14Z |
| format | Article |
| id | doaj.art-d76762a52f3e4acbad9d2a4bbb11f201 |
| institution | Directory Open Access Journal |
| issn | 2050-0904 |
| language | English |
| last_indexed | 2024-04-10T06:31:14Z |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Clinical Case Reports |
| spelling | doaj.art-d76762a52f3e4acbad9d2a4bbb11f2012023-03-01T07:50:56ZengWileyClinical Case Reports2050-09042023-01-01111n/an/a10.1002/ccr3.6814Recurrent sideroblastic anemia during pregnancyShehab Mohamed0Firyal Ibrahim1Mohamad Najib Alasafar2Awni Alshurafa3Susanna Akiki4Dina Soliman5Samah Kohla6Aliaa Amer7Hana Qasim8Honar Cherif9Department of Hematology National Center for Cancer Care and Research, Hamad Medical Corporation Doha QatarDepartment of Laboratory Medicine and Pathology National Center for Cancer Care and Research, Hamad Medical Corporation Doha QatarWomen's Wellness and Research Center, Hamad Medical Corporation Doha QatarDepartment of Hematology National Center for Cancer Care and Research, Hamad Medical Corporation Doha QatarDepartment of Laboratory Medicine and Pathology Hamad Medical Corporation Doha QatarDepartment of Laboratory Medicine and Pathology National Center for Cancer Care and Research, Hamad Medical Corporation Doha QatarDepartment of Laboratory Medicine and Pathology National Center for Cancer Care and Research, Hamad Medical Corporation Doha QatarDepartment of Laboratory Medicine and Pathology National Center for Cancer Care and Research, Hamad Medical Corporation Doha QatarDepartment of Hematology National Center for Cancer Care and Research, Hamad Medical Corporation Doha QatarDepartment of Hematology National Center for Cancer Care and Research, Hamad Medical Corporation Doha QatarAbstract Sideroblastic anemia is a heterogeneous group of disorders typified by the presence of ring sideroblasts in the bone marrow and has congenital and acquired types. Sideroblastic anemia is a rare event in pregnancy. We report a case of a 32‐year‐old female patient, gravida 4 para 3, 27th weeks pregnant, who presented to the emergency department complaining of palpitation and generalized weakness for 2 weeks. She was found to have severe normochromic normocytic anemia, with hemoglobin of 4.2 g/dl, and low reticulocytes count of 13 × 103/μl. She gave a history of recurrent anemia, which had only occurred during pregnancy. Her bone marrow aspirate showed many ring sideroblasts concluding the diagnosis of sideroblastic anemia (SA). Further investigation revealed a significantly low pyridoxine level (vitamin B6) of (8 nmol/L). The Hb level improved with vitamin B6 replacement, without any transfusion support.https://doi.org/10.1002/ccr3.6814acquired sideroblastic anemiacongenital sideroblastic anemiaheme biosynthesisiron chelationring sideroblastsvitamin B6 |
| spellingShingle | Shehab Mohamed Firyal Ibrahim Mohamad Najib Alasafar Awni Alshurafa Susanna Akiki Dina Soliman Samah Kohla Aliaa Amer Hana Qasim Honar Cherif Recurrent sideroblastic anemia during pregnancy Clinical Case Reports acquired sideroblastic anemia congenital sideroblastic anemia heme biosynthesis iron chelation ring sideroblasts vitamin B6 |
| title | Recurrent sideroblastic anemia during pregnancy |
| title_full | Recurrent sideroblastic anemia during pregnancy |
| title_fullStr | Recurrent sideroblastic anemia during pregnancy |
| title_full_unstemmed | Recurrent sideroblastic anemia during pregnancy |
| title_short | Recurrent sideroblastic anemia during pregnancy |
| title_sort | recurrent sideroblastic anemia during pregnancy |
| topic | acquired sideroblastic anemia congenital sideroblastic anemia heme biosynthesis iron chelation ring sideroblasts vitamin B6 |
| url | https://doi.org/10.1002/ccr3.6814 |
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