Nano-Methoxatin Improves Ischemia-Reperfusion Injury in Torsion-Detorsion Model of Ovary
Using a rat ovary model, protective effects of nano-methoxatin (NMXTN) were studied on ischemia-reperfusion injury. Following randomization of forty-eight healthy female Wistar rats ~250 g, the animals were subjected to eight experimental groups (n = 6): Group SHAM: Only laparotomy was performed. Gr...
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| Format: | Article |
| Language: | English |
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Iranian Veterinary Surgery Association (IVSA)
2023-10-01
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| Series: | Iranian Journal of Veterinary Surgery |
| Subjects: | |
| Online Access: | https://www.ivsajournals.com/article_168545_edb5fcd04f5fc016dfb58cd5817ffd13.pdf |
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| author | Kave Koorehpaz Alireza Najafpour Rahim Mohammadi |
| author_facet | Kave Koorehpaz Alireza Najafpour Rahim Mohammadi |
| author_sort | Kave Koorehpaz |
| collection | DOAJ |
| description | Using a rat ovary model, protective effects of nano-methoxatin (NMXTN) were studied on ischemia-reperfusion injury. Following randomization of forty-eight healthy female Wistar rats ~250 g, the animals were subjected to eight experimental groups (n = 6): Group SHAM: Only laparotomy was performed. Group IS: Only a 3-hour ischemia was performed. Group IS/Oil: Only a 3-hour ischemia was performed and 50 µl soybean oil alone (Solvent of MXTN) was administered 30 min before cessation of ischemia. Group IS/REP: The procedure included a 3-hour ischemia followed by a 3-hour reperfusion and 50 µl soybean oil alone was administered 30 min before cessation of ischemia. Group IS/MXTN: The procedure included a 3-hour ischemia only and 50 µl (0.3 mmol/l/IP) of MXTN 30 min before cessation of ischemia. Group IS/NMXTN: The procedure included a 3-hour ischemia only and 50 µl (0. 3 mmol/l/IP) of NMXTN 30 min before cessation of ischemia. Group IS/REP/MXTN: The procedure included a 3-hour ischemia, a 3-hour reperfusion and 20 µl (0.3 mmol/l) of MXTN 30 min before cessation of ischemia. Group IS/REP/NMXTN: The procedure included a 3-hour ischemia, a 3-hour reperfusion and 20 µl (0.3 mmol/l) of NMXTN 30 min before cessation of ischemia. Significantly amended development of ischemia/reperfusion tissue injury was observed in animals treated with NMXTN compared to those of other groups (p = 0.001). Mean values of biochemical indices were significantly higher than those observed for other groups (p = 0.001). Significantly lower values of MDA were observed in IS/REP/NMXTN animals compared to those of other groups (p = 0.001). Where ovarian tissue is exposed to ischemia intraperitoneal administration of NMXTN could bear clinical benefits in diminishing ischemia-reperfusion injury. |
| first_indexed | 2024-03-11T20:47:48Z |
| format | Article |
| id | doaj.art-d767b8651c2d45c497100447a7575063 |
| institution | Directory Open Access Journal |
| issn | 2008-3033 2676-6299 |
| language | English |
| last_indexed | 2024-03-11T20:47:48Z |
| publishDate | 2023-10-01 |
| publisher | Iranian Veterinary Surgery Association (IVSA) |
| record_format | Article |
| series | Iranian Journal of Veterinary Surgery |
| spelling | doaj.art-d767b8651c2d45c497100447a75750632023-10-01T07:22:00ZengIranian Veterinary Surgery Association (IVSA)Iranian Journal of Veterinary Surgery2008-30332676-62992023-10-0118210611210.30500/ivsa.2023.378615.1329168545Nano-Methoxatin Improves Ischemia-Reperfusion Injury in Torsion-Detorsion Model of OvaryKave Koorehpaz0Alireza Najafpour1Rahim Mohammadi2Department of Clinical Sciences, Faculty of Veterinary Medicine, Urmia Branch, Islamic Azad University, Urmia, Iran.Department of Clinical Sciences, Faculty of Veterinary Medicine, Urmia Branch, Islamic Azad University, Urmia, Iran.Department of Surgery and Diagnostic Imaging, Faculty of Veterinary Medicine, Urmia University, Urmia, Iran.Using a rat ovary model, protective effects of nano-methoxatin (NMXTN) were studied on ischemia-reperfusion injury. Following randomization of forty-eight healthy female Wistar rats ~250 g, the animals were subjected to eight experimental groups (n = 6): Group SHAM: Only laparotomy was performed. Group IS: Only a 3-hour ischemia was performed. Group IS/Oil: Only a 3-hour ischemia was performed and 50 µl soybean oil alone (Solvent of MXTN) was administered 30 min before cessation of ischemia. Group IS/REP: The procedure included a 3-hour ischemia followed by a 3-hour reperfusion and 50 µl soybean oil alone was administered 30 min before cessation of ischemia. Group IS/MXTN: The procedure included a 3-hour ischemia only and 50 µl (0.3 mmol/l/IP) of MXTN 30 min before cessation of ischemia. Group IS/NMXTN: The procedure included a 3-hour ischemia only and 50 µl (0. 3 mmol/l/IP) of NMXTN 30 min before cessation of ischemia. Group IS/REP/MXTN: The procedure included a 3-hour ischemia, a 3-hour reperfusion and 20 µl (0.3 mmol/l) of MXTN 30 min before cessation of ischemia. Group IS/REP/NMXTN: The procedure included a 3-hour ischemia, a 3-hour reperfusion and 20 µl (0.3 mmol/l) of NMXTN 30 min before cessation of ischemia. Significantly amended development of ischemia/reperfusion tissue injury was observed in animals treated with NMXTN compared to those of other groups (p = 0.001). Mean values of biochemical indices were significantly higher than those observed for other groups (p = 0.001). Significantly lower values of MDA were observed in IS/REP/NMXTN animals compared to those of other groups (p = 0.001). Where ovarian tissue is exposed to ischemia intraperitoneal administration of NMXTN could bear clinical benefits in diminishing ischemia-reperfusion injury.https://www.ivsajournals.com/article_168545_edb5fcd04f5fc016dfb58cd5817ffd13.pdfnano-methoxatinischemia-reperfusionintraperitonealovary |
| spellingShingle | Kave Koorehpaz Alireza Najafpour Rahim Mohammadi Nano-Methoxatin Improves Ischemia-Reperfusion Injury in Torsion-Detorsion Model of Ovary Iranian Journal of Veterinary Surgery nano-methoxatin ischemia-reperfusion intraperitoneal ovary |
| title | Nano-Methoxatin Improves Ischemia-Reperfusion Injury in Torsion-Detorsion Model of Ovary |
| title_full | Nano-Methoxatin Improves Ischemia-Reperfusion Injury in Torsion-Detorsion Model of Ovary |
| title_fullStr | Nano-Methoxatin Improves Ischemia-Reperfusion Injury in Torsion-Detorsion Model of Ovary |
| title_full_unstemmed | Nano-Methoxatin Improves Ischemia-Reperfusion Injury in Torsion-Detorsion Model of Ovary |
| title_short | Nano-Methoxatin Improves Ischemia-Reperfusion Injury in Torsion-Detorsion Model of Ovary |
| title_sort | nano methoxatin improves ischemia reperfusion injury in torsion detorsion model of ovary |
| topic | nano-methoxatin ischemia-reperfusion intraperitoneal ovary |
| url | https://www.ivsajournals.com/article_168545_edb5fcd04f5fc016dfb58cd5817ffd13.pdf |
| work_keys_str_mv | AT kavekoorehpaz nanomethoxatinimprovesischemiareperfusioninjuryintorsiondetorsionmodelofovary AT alirezanajafpour nanomethoxatinimprovesischemiareperfusioninjuryintorsiondetorsionmodelofovary AT rahimmohammadi nanomethoxatinimprovesischemiareperfusioninjuryintorsiondetorsionmodelofovary |