Colorectal cancer liver metastases – a population-based study on incidence, management and survival
Abstract Background Colorectal cancer (CRC) is a leading cause of cancer-associated deaths with liver metastases developing in 25–30% of those affected. Previous data suggest a survival difference between right- and left-sided liver metastatic CRC, even though left-sided cancer has a higher incidenc...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2018-01-01
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| Series: | BMC Cancer |
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| Online Access: | http://link.springer.com/article/10.1186/s12885-017-3925-x |
| _version_ | 1828542847812370432 |
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| author | Jennie Engstrand Henrik Nilsson Cecilia Strömberg Eduard Jonas Jacob Freedman |
| author_facet | Jennie Engstrand Henrik Nilsson Cecilia Strömberg Eduard Jonas Jacob Freedman |
| author_sort | Jennie Engstrand |
| collection | DOAJ |
| description | Abstract Background Colorectal cancer (CRC) is a leading cause of cancer-associated deaths with liver metastases developing in 25–30% of those affected. Previous data suggest a survival difference between right- and left-sided liver metastatic CRC, even though left-sided cancer has a higher incidence of liver metastases. The aim of the study was to describe the liver metastatic patterns and survival as a function of the characteristics of the primary tumour and different combinations of metastatic disease. Methods A retrospective population-based study was performed on a cohort of patients diagnosed with CRC in the region of Stockholm, Sweden during 2008. Patients were identified through the Swedish National Quality Registry for Colorectal Cancer Treatment (SCRCR) and additional information on intra- and extra-hepatic metastatic pattern and treatment were retrieved from electronic patient records. Patients were followed for 5 years or until death. Factors influencing overall survival (OS) were investigated by means of Cox regression. OS was compared using Kaplan-Meier estimations and the log-rank test. Results Liver metastases were diagnosed in 272/1026 (26.5%) patients within five years of diagnosis of the primary. Liver and lung metastases were more often diagnosed in left-sided colon cancer compared to right-sided cancer (28.4% versus 22.1%, p = 0.029 and 19.7% versus 13.2%, p = 0.010, respectively) but the extent of liver metastases were more extensive for right-sided cancer as compared to left-sided (p = 0.001). Liver metastatic left-sided cancer, including rectal cancer, was associated with a 44% decreased mortality risk compared to right-sided cancer (HR = 0.56, 95% CI: 0.39–0.79) with a 5-year OS of 16.6% versus 4.3% (p < 0.001). In liver metastatic CRC, the presence of lung metastases did not significantly influence OS as assessed by multivariate analysis (HR = 1.11, 95% CI: 0.80–1.53). Conclusion The worse survival in liver metastatic right-sided colon cancer could possibly be explained by the higher number of metastases, as well as more extensive segmental involvement compared with left-sided colon and rectal cancer, even though the latter had a higher incidence of liver metastases. Detailed population-based data on the metastatic pattern of CRC and survival could assist in more structured and individualized guidelines for follow-up of patients with CRC. |
| first_indexed | 2024-12-12T02:04:28Z |
| format | Article |
| id | doaj.art-d767bf900b3c4558bcbc2097b50c74d0 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-12T02:04:28Z |
| publishDate | 2018-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-d767bf900b3c4558bcbc2097b50c74d02022-12-22T00:42:06ZengBMCBMC Cancer1471-24072018-01-0118111110.1186/s12885-017-3925-xColorectal cancer liver metastases – a population-based study on incidence, management and survivalJennie Engstrand0Henrik Nilsson1Cecilia Strömberg2Eduard Jonas3Jacob Freedman4Division of Surgery, Department of Clinical Sciences, Karolinska Institutet at Danderyd HospitalDivision of Surgery, Department of Clinical Sciences, Karolinska Institutet at Danderyd HospitalDivision of Surgery, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet at Karolinska University HospitalDivision of Surgery, Department of Clinical Science, Intervention and Technology (CLINTEC), Karolinska Institutet at Karolinska University HospitalDivision of Surgery, Department of Clinical Sciences, Karolinska Institutet at Danderyd HospitalAbstract Background Colorectal cancer (CRC) is a leading cause of cancer-associated deaths with liver metastases developing in 25–30% of those affected. Previous data suggest a survival difference between right- and left-sided liver metastatic CRC, even though left-sided cancer has a higher incidence of liver metastases. The aim of the study was to describe the liver metastatic patterns and survival as a function of the characteristics of the primary tumour and different combinations of metastatic disease. Methods A retrospective population-based study was performed on a cohort of patients diagnosed with CRC in the region of Stockholm, Sweden during 2008. Patients were identified through the Swedish National Quality Registry for Colorectal Cancer Treatment (SCRCR) and additional information on intra- and extra-hepatic metastatic pattern and treatment were retrieved from electronic patient records. Patients were followed for 5 years or until death. Factors influencing overall survival (OS) were investigated by means of Cox regression. OS was compared using Kaplan-Meier estimations and the log-rank test. Results Liver metastases were diagnosed in 272/1026 (26.5%) patients within five years of diagnosis of the primary. Liver and lung metastases were more often diagnosed in left-sided colon cancer compared to right-sided cancer (28.4% versus 22.1%, p = 0.029 and 19.7% versus 13.2%, p = 0.010, respectively) but the extent of liver metastases were more extensive for right-sided cancer as compared to left-sided (p = 0.001). Liver metastatic left-sided cancer, including rectal cancer, was associated with a 44% decreased mortality risk compared to right-sided cancer (HR = 0.56, 95% CI: 0.39–0.79) with a 5-year OS of 16.6% versus 4.3% (p < 0.001). In liver metastatic CRC, the presence of lung metastases did not significantly influence OS as assessed by multivariate analysis (HR = 1.11, 95% CI: 0.80–1.53). Conclusion The worse survival in liver metastatic right-sided colon cancer could possibly be explained by the higher number of metastases, as well as more extensive segmental involvement compared with left-sided colon and rectal cancer, even though the latter had a higher incidence of liver metastases. Detailed population-based data on the metastatic pattern of CRC and survival could assist in more structured and individualized guidelines for follow-up of patients with CRC.http://link.springer.com/article/10.1186/s12885-017-3925-xColorectal cancerLiver metastasesRight-sided cancerLeft-sided cancerExtra-hepatic metastasesSurvival |
| spellingShingle | Jennie Engstrand Henrik Nilsson Cecilia Strömberg Eduard Jonas Jacob Freedman Colorectal cancer liver metastases – a population-based study on incidence, management and survival BMC Cancer Colorectal cancer Liver metastases Right-sided cancer Left-sided cancer Extra-hepatic metastases Survival |
| title | Colorectal cancer liver metastases – a population-based study on incidence, management and survival |
| title_full | Colorectal cancer liver metastases – a population-based study on incidence, management and survival |
| title_fullStr | Colorectal cancer liver metastases – a population-based study on incidence, management and survival |
| title_full_unstemmed | Colorectal cancer liver metastases – a population-based study on incidence, management and survival |
| title_short | Colorectal cancer liver metastases – a population-based study on incidence, management and survival |
| title_sort | colorectal cancer liver metastases a population based study on incidence management and survival |
| topic | Colorectal cancer Liver metastases Right-sided cancer Left-sided cancer Extra-hepatic metastases Survival |
| url | http://link.springer.com/article/10.1186/s12885-017-3925-x |
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