Dysregulated Microglial Cell Activation and Proliferation Following Repeated Antigen Stimulation

Dysregulated Microglial Cell Activation and Proliferation Following Repeated Antigen Stimulation

Upon reactivation of quiescent neurotropic viruses antigen (Ag)-specific brain resident-memory CD8+ T-cells (bTRM) may respond to de novo-produced viral Ag through the rapid release of IFN-γ, which drives subsequent interferon-stimulated gene expression in surrounding microglia. Through this mechani...

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Bibliographic Details
Main Authors:	Sujata Prasad, Wen S. Sheng, Shuxian Hu, Priyanka Chauhan, James R. Lokensgard
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2021-08-01
Series:	Frontiers in Cellular Neuroscience
Subjects:	viral reactivation microglia neurotoxicity reactive gliosis resident memory T-cells immune activation
Online Access:	https://www.frontiersin.org/articles/10.3389/fncel.2021.686340/full

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