Progression of precancerous lesions of esophageal squamous cell carcinomas in a high‐risk, rural Chinese population
Abstract Background and aims This study investigated the natural history of esophageal squamous cell carcinoma (ESCC) in rural Chinese. We sought to help provide more data to support ESCC screenings. Methods This study was based on an existing Screening Program in Feicheng, China. Esophageal precanc...
| Main Authors: | , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wiley
2023-01-01
|
| Series: | Cancer Medicine |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/cam4.4965 |
| _version_ | 1811176412932997120 |
|---|---|
| author | Dongqing Gao Peipei Lu Nan Zhang Li Zhao Jinhui Liu Jia Yang Jingmin Liu Deli Zhao Jialin Wang |
| author_facet | Dongqing Gao Peipei Lu Nan Zhang Li Zhao Jinhui Liu Jia Yang Jingmin Liu Deli Zhao Jialin Wang |
| author_sort | Dongqing Gao |
| collection | DOAJ |
| description | Abstract Background and aims This study investigated the natural history of esophageal squamous cell carcinoma (ESCC) in rural Chinese. We sought to help provide more data to support ESCC screenings. Methods This study was based on an existing Screening Program in Feicheng, China. Esophageal precancerous lesions were identified in 1753 cases, diagnosed from esophageal cancer screenings from 2006 to 2016. We followed up with them through endoscopic screening until October 1, 2017. Pathology results from various grades of precancerous lesions were recorded and the annual transition probabilities and incidence density of ESCC were calculated. Results As of October 1, 2017, a total of 4055.8 person‐years has been observed. The ESCC incidence density of mild, moderate, and severe dysplasia (SD) was 0.17, 0.79, and 1.77 per 100 person‐years, respectively. The median follow‐up time of mild, moderate, and SD was 3.5, 2.3, and 2.2 years, respectively. The annual transition probability of mild, moderate, and SD to the next pathological level was 0.025, 0.038, and 0.016, respectively. The ESCC incidence density of males was 2.6 times higher than females (0.58 vs. 0.22), and the older age group (56–69 age group) had a ESCC incidence density 1.2 times higher than the younger group (40–55 age group) (0.45 vs. 0.39). Conclusions The higher the grade of precancerous lesions, the higher the incidence density of ESCC. Screening of esophageal cancer in males and the elderly should be strengthened. It is recommended to reinforce follow‐up management for untreated patients with SD/carcinoma in situ. For patients with mild and moderate dysplasia in high‐risk rural Chinese populations, endoscopic follow‐up intervals can be appropriately adjusted to once every 2 years. |
| first_indexed | 2024-04-10T19:52:12Z |
| format | Article |
| id | doaj.art-d768e7e1d1ad44e2a4a4935d0806c149 |
| institution | Directory Open Access Journal |
| issn | 2045-7634 |
| language | English |
| last_indexed | 2024-04-10T19:52:12Z |
| publishDate | 2023-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj.art-d768e7e1d1ad44e2a4a4935d0806c1492023-01-28T05:30:05ZengWileyCancer Medicine2045-76342023-01-011221791180010.1002/cam4.4965Progression of precancerous lesions of esophageal squamous cell carcinomas in a high‐risk, rural Chinese populationDongqing Gao0Peipei Lu1Nan Zhang2Li Zhao3Jinhui Liu4Jia Yang5Jingmin Liu6Deli Zhao7Jialin Wang8Jining NO.1 People's Hospital Jining ChinaShandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical Sciences Jinan ChinaShandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical Sciences Jinan ChinaCancer Center, People's Hospital of Feicheng Taian ChinaShandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical Sciences Jinan ChinaShandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical Sciences Jinan ChinaSchool of Public Health Weifang Medical University Weifang ChinaCancer Center, People's Hospital of Feicheng Taian ChinaShandong Cancer Hospital and Institute Shandong First Medical University and Shandong Academy of Medical Sciences Jinan ChinaAbstract Background and aims This study investigated the natural history of esophageal squamous cell carcinoma (ESCC) in rural Chinese. We sought to help provide more data to support ESCC screenings. Methods This study was based on an existing Screening Program in Feicheng, China. Esophageal precancerous lesions were identified in 1753 cases, diagnosed from esophageal cancer screenings from 2006 to 2016. We followed up with them through endoscopic screening until October 1, 2017. Pathology results from various grades of precancerous lesions were recorded and the annual transition probabilities and incidence density of ESCC were calculated. Results As of October 1, 2017, a total of 4055.8 person‐years has been observed. The ESCC incidence density of mild, moderate, and severe dysplasia (SD) was 0.17, 0.79, and 1.77 per 100 person‐years, respectively. The median follow‐up time of mild, moderate, and SD was 3.5, 2.3, and 2.2 years, respectively. The annual transition probability of mild, moderate, and SD to the next pathological level was 0.025, 0.038, and 0.016, respectively. The ESCC incidence density of males was 2.6 times higher than females (0.58 vs. 0.22), and the older age group (56–69 age group) had a ESCC incidence density 1.2 times higher than the younger group (40–55 age group) (0.45 vs. 0.39). Conclusions The higher the grade of precancerous lesions, the higher the incidence density of ESCC. Screening of esophageal cancer in males and the elderly should be strengthened. It is recommended to reinforce follow‐up management for untreated patients with SD/carcinoma in situ. For patients with mild and moderate dysplasia in high‐risk rural Chinese populations, endoscopic follow‐up intervals can be appropriately adjusted to once every 2 years.https://doi.org/10.1002/cam4.4965annual transition probabilityesophageal squamous cell carcinomafollow‐upnatural historyprecancerous lesions |
| spellingShingle | Dongqing Gao Peipei Lu Nan Zhang Li Zhao Jinhui Liu Jia Yang Jingmin Liu Deli Zhao Jialin Wang Progression of precancerous lesions of esophageal squamous cell carcinomas in a high‐risk, rural Chinese population Cancer Medicine annual transition probability esophageal squamous cell carcinoma follow‐up natural history precancerous lesions |
| title | Progression of precancerous lesions of esophageal squamous cell carcinomas in a high‐risk, rural Chinese population |
| title_full | Progression of precancerous lesions of esophageal squamous cell carcinomas in a high‐risk, rural Chinese population |
| title_fullStr | Progression of precancerous lesions of esophageal squamous cell carcinomas in a high‐risk, rural Chinese population |
| title_full_unstemmed | Progression of precancerous lesions of esophageal squamous cell carcinomas in a high‐risk, rural Chinese population |
| title_short | Progression of precancerous lesions of esophageal squamous cell carcinomas in a high‐risk, rural Chinese population |
| title_sort | progression of precancerous lesions of esophageal squamous cell carcinomas in a high risk rural chinese population |
| topic | annual transition probability esophageal squamous cell carcinoma follow‐up natural history precancerous lesions |
| url | https://doi.org/10.1002/cam4.4965 |
| work_keys_str_mv | AT dongqinggao progressionofprecancerouslesionsofesophagealsquamouscellcarcinomasinahighriskruralchinesepopulation AT peipeilu progressionofprecancerouslesionsofesophagealsquamouscellcarcinomasinahighriskruralchinesepopulation AT nanzhang progressionofprecancerouslesionsofesophagealsquamouscellcarcinomasinahighriskruralchinesepopulation AT lizhao progressionofprecancerouslesionsofesophagealsquamouscellcarcinomasinahighriskruralchinesepopulation AT jinhuiliu progressionofprecancerouslesionsofesophagealsquamouscellcarcinomasinahighriskruralchinesepopulation AT jiayang progressionofprecancerouslesionsofesophagealsquamouscellcarcinomasinahighriskruralchinesepopulation AT jingminliu progressionofprecancerouslesionsofesophagealsquamouscellcarcinomasinahighriskruralchinesepopulation AT delizhao progressionofprecancerouslesionsofesophagealsquamouscellcarcinomasinahighriskruralchinesepopulation AT jialinwang progressionofprecancerouslesionsofesophagealsquamouscellcarcinomasinahighriskruralchinesepopulation |