| Summary: | <i>Background:</i> Phytoncide is known to have antimicrobial and anti-inflammatory properties. <i>Purpose:</i> This study was carried out to confirm the anti-inflammatory activity of two types of phytoncide extracts from pinecone waste. <i>Methods:</i> We made two types of animal models to evaluate the efficacy, an indomethacin-induced gastroenteritis rat model and a dextran sulfate sodium-induced colitis mouse model. <i>Result:</i> In the gastroenteritis experiment, the expression of induced-nitric oxide synthase (iNOS), a marker for inflammation, decreased in the phytoncide-supplemented groups, and gastric ulcer development was significantly inhibited (<i>p</i> < 0.05). In the colitis experiment, the shortening of the colon length and the iNOS expression were significantly suppressed in the phytoncide-supplemented group (<i>p</i> < 0.05). <i>Conclusions:</i> Through this study, we confirmed that phytoncide can directly inhibit inflammation in digestive organs. Although further research is needed, we conclude that phytoncide has potential anti-inflammatory properties in the digestive tract and can be developed as a functional agent.
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