Anti-Inflammatory Effect of Phytoncide in an Animal Model of Gastrointestinal Inflammation
<i>Background:</i> Phytoncide is known to have antimicrobial and anti-inflammatory properties. <i>Purpose:</i> This study was carried out to confirm the anti-inflammatory activity of two types of phytoncide extracts from pinecone waste. <i>Methods:</i> We made two...
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| Format: | Article |
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MDPI AG
2021-03-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/26/7/1895 |
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| author | Azra Memon Bae Yong Kim Se-eun Kim Yuliya Pyao Yeong-Geun Lee Se Chan Kang Woon Kyu Lee |
| author_facet | Azra Memon Bae Yong Kim Se-eun Kim Yuliya Pyao Yeong-Geun Lee Se Chan Kang Woon Kyu Lee |
| author_sort | Azra Memon |
| collection | DOAJ |
| description | <i>Background:</i> Phytoncide is known to have antimicrobial and anti-inflammatory properties. <i>Purpose:</i> This study was carried out to confirm the anti-inflammatory activity of two types of phytoncide extracts from pinecone waste. <i>Methods:</i> We made two types of animal models to evaluate the efficacy, an indomethacin-induced gastroenteritis rat model and a dextran sulfate sodium-induced colitis mouse model. <i>Result:</i> In the gastroenteritis experiment, the expression of induced-nitric oxide synthase (iNOS), a marker for inflammation, decreased in the phytoncide-supplemented groups, and gastric ulcer development was significantly inhibited (<i>p</i> < 0.05). In the colitis experiment, the shortening of the colon length and the iNOS expression were significantly suppressed in the phytoncide-supplemented group (<i>p</i> < 0.05). <i>Conclusions:</i> Through this study, we confirmed that phytoncide can directly inhibit inflammation in digestive organs. Although further research is needed, we conclude that phytoncide has potential anti-inflammatory properties in the digestive tract and can be developed as a functional agent. |
| first_indexed | 2024-03-10T12:51:42Z |
| format | Article |
| id | doaj.art-d76a3a81a9794b19a5da860d95a16e6d |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-10T12:51:42Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-d76a3a81a9794b19a5da860d95a16e6d2023-11-21T13:01:56ZengMDPI AGMolecules1420-30492021-03-01267189510.3390/molecules26071895Anti-Inflammatory Effect of Phytoncide in an Animal Model of Gastrointestinal InflammationAzra Memon0Bae Yong Kim1Se-eun Kim2Yuliya Pyao3Yeong-Geun Lee4Se Chan Kang5Woon Kyu Lee6Department of Biomedical Sciences, School of Medicine, Inha University, Incheon 22212, KoreaResearch Institute, Phylus Co., LTD., Danyang-gun 27000, KoreaDepartment of Oriental Medicine Biotechnology, College of Life Sciences, Kyung Hee University, Yongin-si 17104, KoreaDepartment of Biomedical Sciences, School of Medicine, Inha University, Incheon 22212, KoreaDepartment of Oriental Medicine Biotechnology, College of Life Sciences, Kyung Hee University, Yongin-si 17104, KoreaDepartment of Oriental Medicine Biotechnology, College of Life Sciences, Kyung Hee University, Yongin-si 17104, KoreaDepartment of Biomedical Sciences, School of Medicine, Inha University, Incheon 22212, Korea<i>Background:</i> Phytoncide is known to have antimicrobial and anti-inflammatory properties. <i>Purpose:</i> This study was carried out to confirm the anti-inflammatory activity of two types of phytoncide extracts from pinecone waste. <i>Methods:</i> We made two types of animal models to evaluate the efficacy, an indomethacin-induced gastroenteritis rat model and a dextran sulfate sodium-induced colitis mouse model. <i>Result:</i> In the gastroenteritis experiment, the expression of induced-nitric oxide synthase (iNOS), a marker for inflammation, decreased in the phytoncide-supplemented groups, and gastric ulcer development was significantly inhibited (<i>p</i> < 0.05). In the colitis experiment, the shortening of the colon length and the iNOS expression were significantly suppressed in the phytoncide-supplemented group (<i>p</i> < 0.05). <i>Conclusions:</i> Through this study, we confirmed that phytoncide can directly inhibit inflammation in digestive organs. Although further research is needed, we conclude that phytoncide has potential anti-inflammatory properties in the digestive tract and can be developed as a functional agent.https://www.mdpi.com/1420-3049/26/7/1895<i>Pinus koraiensis</i>phytoncideanti-inflammationgastritiscolitis |
| spellingShingle | Azra Memon Bae Yong Kim Se-eun Kim Yuliya Pyao Yeong-Geun Lee Se Chan Kang Woon Kyu Lee Anti-Inflammatory Effect of Phytoncide in an Animal Model of Gastrointestinal Inflammation Molecules <i>Pinus koraiensis</i> phytoncide anti-inflammation gastritis colitis |
| title | Anti-Inflammatory Effect of Phytoncide in an Animal Model of Gastrointestinal Inflammation |
| title_full | Anti-Inflammatory Effect of Phytoncide in an Animal Model of Gastrointestinal Inflammation |
| title_fullStr | Anti-Inflammatory Effect of Phytoncide in an Animal Model of Gastrointestinal Inflammation |
| title_full_unstemmed | Anti-Inflammatory Effect of Phytoncide in an Animal Model of Gastrointestinal Inflammation |
| title_short | Anti-Inflammatory Effect of Phytoncide in an Animal Model of Gastrointestinal Inflammation |
| title_sort | anti inflammatory effect of phytoncide in an animal model of gastrointestinal inflammation |
| topic | <i>Pinus koraiensis</i> phytoncide anti-inflammation gastritis colitis |
| url | https://www.mdpi.com/1420-3049/26/7/1895 |
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