Mortality from Parkinson’s disease and other causes among a workforce manufacturing paraquat: an updated retrospective cohort study
Abstract Background Epidemiological studies of the association between Parkinson’s disease (PD) and paraquat (PQ) exposure have given inconsistent findings. The aim of the study was to update information on the risk of PD and mortality from major causes of death among a UK workforce who manufactured...
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| Format: | Article |
| Language: | English |
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BMC
2021-05-01
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| Series: | Journal of Occupational Medicine and Toxicology |
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| Online Access: | https://doi.org/10.1186/s12995-021-00309-z |
| _version_ | 1811279572350533632 |
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| author | John Andrew Tomenson Clive Campbell |
| author_facet | John Andrew Tomenson Clive Campbell |
| author_sort | John Andrew Tomenson |
| collection | DOAJ |
| description | Abstract Background Epidemiological studies of the association between Parkinson’s disease (PD) and paraquat (PQ) exposure have given inconsistent findings. The aim of the study was to update information on the risk of PD and mortality from major causes of death among a UK workforce who manufactured PQ by extending the follow-up by seven and a half years. Methods This retrospective cohort study included all employees who had ever worked on any of the four plants at Widnes, UK where PQ was manufactured between 1961 and 1995. The 926 male and 42 female workers were followed through 31 December 2017. Mortalities for males were compared with national and local rates, including rates for PD as a mentioned cause of death. Results A total of 394 male and 21 female workers had died by end of follow-up. Four death certificates of male workers mentioned PD, including two deaths that were due to PD. At least 6 death certificates of male employees would have been expected to have mentioned PD (SMR = 0.67; 95% CI 0.18–1.72). Reduced mortalities compared with local rates were found for major causes of death. Conclusions The study provided no evidence of an increased risk of PD, or increased mortalities from other causes among PQ production workers whose exposure to PQ on a daily basis was at least comparable to that of a PQ sprayer or mixer/loader. |
| first_indexed | 2024-04-13T00:58:06Z |
| format | Article |
| id | doaj.art-d76bc3d89f8845ec9ab25021c6f7b4f0 |
| institution | Directory Open Access Journal |
| issn | 1745-6673 |
| language | English |
| last_indexed | 2024-04-13T00:58:06Z |
| publishDate | 2021-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Occupational Medicine and Toxicology |
| spelling | doaj.art-d76bc3d89f8845ec9ab25021c6f7b4f02022-12-22T03:09:36ZengBMCJournal of Occupational Medicine and Toxicology1745-66732021-05-011611810.1186/s12995-021-00309-zMortality from Parkinson’s disease and other causes among a workforce manufacturing paraquat: an updated retrospective cohort studyJohn Andrew Tomenson0Clive Campbell1Causation LtdSyngenta Crop Protection AGAbstract Background Epidemiological studies of the association between Parkinson’s disease (PD) and paraquat (PQ) exposure have given inconsistent findings. The aim of the study was to update information on the risk of PD and mortality from major causes of death among a UK workforce who manufactured PQ by extending the follow-up by seven and a half years. Methods This retrospective cohort study included all employees who had ever worked on any of the four plants at Widnes, UK where PQ was manufactured between 1961 and 1995. The 926 male and 42 female workers were followed through 31 December 2017. Mortalities for males were compared with national and local rates, including rates for PD as a mentioned cause of death. Results A total of 394 male and 21 female workers had died by end of follow-up. Four death certificates of male workers mentioned PD, including two deaths that were due to PD. At least 6 death certificates of male employees would have been expected to have mentioned PD (SMR = 0.67; 95% CI 0.18–1.72). Reduced mortalities compared with local rates were found for major causes of death. Conclusions The study provided no evidence of an increased risk of PD, or increased mortalities from other causes among PQ production workers whose exposure to PQ on a daily basis was at least comparable to that of a PQ sprayer or mixer/loader.https://doi.org/10.1186/s12995-021-00309-zParkinson’s diseaseParaquatCohort studyMortality studyPesticides |
| spellingShingle | John Andrew Tomenson Clive Campbell Mortality from Parkinson’s disease and other causes among a workforce manufacturing paraquat: an updated retrospective cohort study Journal of Occupational Medicine and Toxicology Parkinson’s disease Paraquat Cohort study Mortality study Pesticides |
| title | Mortality from Parkinson’s disease and other causes among a workforce manufacturing paraquat: an updated retrospective cohort study |
| title_full | Mortality from Parkinson’s disease and other causes among a workforce manufacturing paraquat: an updated retrospective cohort study |
| title_fullStr | Mortality from Parkinson’s disease and other causes among a workforce manufacturing paraquat: an updated retrospective cohort study |
| title_full_unstemmed | Mortality from Parkinson’s disease and other causes among a workforce manufacturing paraquat: an updated retrospective cohort study |
| title_short | Mortality from Parkinson’s disease and other causes among a workforce manufacturing paraquat: an updated retrospective cohort study |
| title_sort | mortality from parkinson s disease and other causes among a workforce manufacturing paraquat an updated retrospective cohort study |
| topic | Parkinson’s disease Paraquat Cohort study Mortality study Pesticides |
| url | https://doi.org/10.1186/s12995-021-00309-z |
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