Microwave assisted metal-free approach to access 1,2,3-triazoles through multicomponent synthesis
The work illustrates multicomponent reaction of aldehydes, nitroalkanes and sodium azide for the metal-free synthesis of N-unsubstituted-1,2,3-triazoles using anthranilic acid as an organocatalyst under microwave irradiation. This is the first ever green protocol to synthesize 4-aryl-NH-1,2,3-triazo...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2020-06-01
|
| Series: | Current Research in Green and Sustainable Chemistry |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666086520300163 |
| _version_ | 1819057344170950656 |
|---|---|
| author | Anirban Garg Diganta Sarma Abdul Aziz Ali |
| author_facet | Anirban Garg Diganta Sarma Abdul Aziz Ali |
| author_sort | Anirban Garg |
| collection | DOAJ |
| description | The work illustrates multicomponent reaction of aldehydes, nitroalkanes and sodium azide for the metal-free synthesis of N-unsubstituted-1,2,3-triazoles using anthranilic acid as an organocatalyst under microwave irradiation. This is the first ever green protocol to synthesize 4-aryl-NH-1,2,3-triazoles from aromatic aldehyde, nitroalkane and sodium azide under microwave condition and offers broad substrate scope with good to excellent yields. Furthermore, using this efficient protocol gram scale synthesis of biologically important molecules were successfully carried out. |
| first_indexed | 2024-12-21T13:37:49Z |
| format | Article |
| id | doaj.art-d76f09756f9a4418aaa2c072ac32bab7 |
| institution | Directory Open Access Journal |
| issn | 2666-0865 |
| language | English |
| last_indexed | 2024-12-21T13:37:49Z |
| publishDate | 2020-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Research in Green and Sustainable Chemistry |
| spelling | doaj.art-d76f09756f9a4418aaa2c072ac32bab72022-12-21T19:02:08ZengElsevierCurrent Research in Green and Sustainable Chemistry2666-08652020-06-013100013Microwave assisted metal-free approach to access 1,2,3-triazoles through multicomponent synthesisAnirban Garg0Diganta Sarma1Abdul Aziz Ali2Department of Chemistry, Dibrugarh University, Dibrugarh-786004, Assam, IndiaDepartment of Chemistry, Dibrugarh University, Dibrugarh-786004, Assam, India; Corresponding author.Department of Chemistry, Dibrugarh University, Dibrugarh-786004, Assam, India; Material Science & Technology Division, CSIR-NEIST, Jorhat-785006, Assam, India; Corresponding author. Department of Chemistry, Dibrugarh University, Dibrugarh-786004, Assam, India.The work illustrates multicomponent reaction of aldehydes, nitroalkanes and sodium azide for the metal-free synthesis of N-unsubstituted-1,2,3-triazoles using anthranilic acid as an organocatalyst under microwave irradiation. This is the first ever green protocol to synthesize 4-aryl-NH-1,2,3-triazoles from aromatic aldehyde, nitroalkane and sodium azide under microwave condition and offers broad substrate scope with good to excellent yields. Furthermore, using this efficient protocol gram scale synthesis of biologically important molecules were successfully carried out.http://www.sciencedirect.com/science/article/pii/S2666086520300163Metal-free4-aryl–NH–1,2,3-triazolesMulticomponent reactionsMicrowave condition |
| spellingShingle | Anirban Garg Diganta Sarma Abdul Aziz Ali Microwave assisted metal-free approach to access 1,2,3-triazoles through multicomponent synthesis Current Research in Green and Sustainable Chemistry Metal-free 4-aryl–NH–1,2,3-triazoles Multicomponent reactions Microwave condition |
| title | Microwave assisted metal-free approach to access 1,2,3-triazoles through multicomponent synthesis |
| title_full | Microwave assisted metal-free approach to access 1,2,3-triazoles through multicomponent synthesis |
| title_fullStr | Microwave assisted metal-free approach to access 1,2,3-triazoles through multicomponent synthesis |
| title_full_unstemmed | Microwave assisted metal-free approach to access 1,2,3-triazoles through multicomponent synthesis |
| title_short | Microwave assisted metal-free approach to access 1,2,3-triazoles through multicomponent synthesis |
| title_sort | microwave assisted metal free approach to access 1 2 3 triazoles through multicomponent synthesis |
| topic | Metal-free 4-aryl–NH–1,2,3-triazoles Multicomponent reactions Microwave condition |
| url | http://www.sciencedirect.com/science/article/pii/S2666086520300163 |
| work_keys_str_mv | AT anirbangarg microwaveassistedmetalfreeapproachtoaccess123triazolesthroughmulticomponentsynthesis AT digantasarma microwaveassistedmetalfreeapproachtoaccess123triazolesthroughmulticomponentsynthesis AT abdulazizali microwaveassistedmetalfreeapproachtoaccess123triazolesthroughmulticomponentsynthesis |