Influence of early colorectal cancer component on the positive margins after endoscopic resection: a retrospective study
Abstract Background Endoscopic treatment methods for early colorectal cancer (ECRC) mainly depend on the size and morphology. It is unclear whether different endoscopic resection methods could achieve curative resection for ECRC confined in the mucosa. The study was designed to compare the rate of p...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2022-01-01
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| Series: | BMC Cancer |
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| Online Access: | https://doi.org/10.1186/s12885-021-09159-8 |
| _version_ | 1819280859699609600 |
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| author | Qing-Wei Zhang Zi-Hao Dai Xiao-Yi Wang Yun-Jie Gao Zhi-Zheng Ge Xiao-Bo Li |
| author_facet | Qing-Wei Zhang Zi-Hao Dai Xiao-Yi Wang Yun-Jie Gao Zhi-Zheng Ge Xiao-Bo Li |
| author_sort | Qing-Wei Zhang |
| collection | DOAJ |
| description | Abstract Background Endoscopic treatment methods for early colorectal cancer (ECRC) mainly depend on the size and morphology. It is unclear whether different endoscopic resection methods could achieve curative resection for ECRC confined in the mucosa. The study was designed to compare the rate of positive vertical margin (VM) of ECRC with advanced adenomas (AAs) including adenoma > 1 cm, villous adenoma, high-grade intraepithelial neoplasia/dysplasia stratified by different endoscopic resection methods. Methods Rate of positive VM for 489 ECRCs including Intramucosal (pTis) and superficial submucosal invasion (pT1) carcinomas were compared with those of 753 AAs stratified by different endoscopic resection methods using Chi-squared test. Multivariate logistic model was performed to investigate the risk factors of positive VM for different endoscopic resection methods. Results The pTis ECRC exhibited a similar rate of positive VM as that of AAs for en bloc hot snare polypectomy (HSP, 0% Vs. 0.85%, P = 0.617), endoscopic mucosal resection (EMR, 0.81% vs. 0.25%, P = 0.375) and endoscopic submucosal dissection (ESD, 1.82% Vs. 1.02%, P = 0.659). The pTis carcinoma was not found to be a risk factor for positive VM by en bloc EMR (P = 0.349) or ESD (P = 0.368). The en bloc resection achieved for pT1a carcinomas exhibited similar to positive VM achieved through ESD (2.06% Vs. 1.02%, P = 1.000) for AAs. Nonetheless, EMR resulted in higher risk of positive VM (5.41% Vs. 0.25%, P < 0.001) for pT1a carcinomas as compared to AAs. The pT1a invasion was identified as a risk factor for positive VM in polyps with en bloc EMR (odds ratio = 23.90, P = 0.005) but not ESD (OR = 2.96, P = 0.396). Conclusion Collectively, the pTis carcinoma was not found to be a risk factor for positive VM resected by en bloc HSP, EMR or ESD. Additionally, ESD may be preferred over EMR for pT1a carcinomas with lower rate of positive VM. |
| first_indexed | 2024-12-24T00:50:30Z |
| format | Article |
| id | doaj.art-d77001b8396c495abcf2b7087eb3f223 |
| institution | Directory Open Access Journal |
| issn | 1471-2407 |
| language | English |
| last_indexed | 2024-12-24T00:50:30Z |
| publishDate | 2022-01-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Cancer |
| spelling | doaj.art-d77001b8396c495abcf2b7087eb3f2232022-12-21T17:23:36ZengBMCBMC Cancer1471-24072022-01-012211710.1186/s12885-021-09159-8Influence of early colorectal cancer component on the positive margins after endoscopic resection: a retrospective studyQing-Wei Zhang0Zi-Hao Dai1Xiao-Yi Wang2Yun-Jie Gao3Zhi-Zheng Ge4Xiao-Bo Li5Division of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive DiseaseDivision of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive DiseaseDivision of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive DiseaseDivision of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive DiseaseDivision of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive DiseaseDivision of Gastroenterology and Hepatology, Key Laboratory of Gastroenterology and Hepatology, Ministry of Health, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai Institute of Digestive DiseaseAbstract Background Endoscopic treatment methods for early colorectal cancer (ECRC) mainly depend on the size and morphology. It is unclear whether different endoscopic resection methods could achieve curative resection for ECRC confined in the mucosa. The study was designed to compare the rate of positive vertical margin (VM) of ECRC with advanced adenomas (AAs) including adenoma > 1 cm, villous adenoma, high-grade intraepithelial neoplasia/dysplasia stratified by different endoscopic resection methods. Methods Rate of positive VM for 489 ECRCs including Intramucosal (pTis) and superficial submucosal invasion (pT1) carcinomas were compared with those of 753 AAs stratified by different endoscopic resection methods using Chi-squared test. Multivariate logistic model was performed to investigate the risk factors of positive VM for different endoscopic resection methods. Results The pTis ECRC exhibited a similar rate of positive VM as that of AAs for en bloc hot snare polypectomy (HSP, 0% Vs. 0.85%, P = 0.617), endoscopic mucosal resection (EMR, 0.81% vs. 0.25%, P = 0.375) and endoscopic submucosal dissection (ESD, 1.82% Vs. 1.02%, P = 0.659). The pTis carcinoma was not found to be a risk factor for positive VM by en bloc EMR (P = 0.349) or ESD (P = 0.368). The en bloc resection achieved for pT1a carcinomas exhibited similar to positive VM achieved through ESD (2.06% Vs. 1.02%, P = 1.000) for AAs. Nonetheless, EMR resulted in higher risk of positive VM (5.41% Vs. 0.25%, P < 0.001) for pT1a carcinomas as compared to AAs. The pT1a invasion was identified as a risk factor for positive VM in polyps with en bloc EMR (odds ratio = 23.90, P = 0.005) but not ESD (OR = 2.96, P = 0.396). Conclusion Collectively, the pTis carcinoma was not found to be a risk factor for positive VM resected by en bloc HSP, EMR or ESD. Additionally, ESD may be preferred over EMR for pT1a carcinomas with lower rate of positive VM.https://doi.org/10.1186/s12885-021-09159-8Early colorectal cancerEndoscopic submucosal dissectionEndoscopic mucosal resectionHot snare polypectomyVertical margin |
| spellingShingle | Qing-Wei Zhang Zi-Hao Dai Xiao-Yi Wang Yun-Jie Gao Zhi-Zheng Ge Xiao-Bo Li Influence of early colorectal cancer component on the positive margins after endoscopic resection: a retrospective study BMC Cancer Early colorectal cancer Endoscopic submucosal dissection Endoscopic mucosal resection Hot snare polypectomy Vertical margin |
| title | Influence of early colorectal cancer component on the positive margins after endoscopic resection: a retrospective study |
| title_full | Influence of early colorectal cancer component on the positive margins after endoscopic resection: a retrospective study |
| title_fullStr | Influence of early colorectal cancer component on the positive margins after endoscopic resection: a retrospective study |
| title_full_unstemmed | Influence of early colorectal cancer component on the positive margins after endoscopic resection: a retrospective study |
| title_short | Influence of early colorectal cancer component on the positive margins after endoscopic resection: a retrospective study |
| title_sort | influence of early colorectal cancer component on the positive margins after endoscopic resection a retrospective study |
| topic | Early colorectal cancer Endoscopic submucosal dissection Endoscopic mucosal resection Hot snare polypectomy Vertical margin |
| url | https://doi.org/10.1186/s12885-021-09159-8 |
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