IVIM diffusion-weighted imaging of the liver at 3.0 T: Comparison with 1.5 T
Purpose: To compare intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) of the liver between 1.5 T and 3.0 T in terms of parameter quantification and inter-platform reproducibility. Materials and methods: In this IRB approved prospective study, 19 subjects (17 patients with chronic...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2015-01-01
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| Series: | European Journal of Radiology Open |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352047715300046 |
| _version_ | 1818273000488697856 |
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| author | Yong Cui Hadrien Dyvorne Cecilia Besa Nancy Cooper Bachir Taouli |
| author_facet | Yong Cui Hadrien Dyvorne Cecilia Besa Nancy Cooper Bachir Taouli |
| author_sort | Yong Cui |
| collection | DOAJ |
| description | Purpose: To compare intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) of the liver between 1.5 T and 3.0 T in terms of parameter quantification and inter-platform reproducibility.
Materials and methods: In this IRB approved prospective study, 19 subjects (17 patients with chronic liver disease and 2 healthy volunteers) underwent two repeat scans at 1.5 T and 3.0 T. Each scan included IVIM DWI using 16 b values from 0 to 800 s/mm2. A single observer measured IVIM parameters for each platform and estimated signal to noise ratio (eSNR) at b0, 200, 400 and 800 s/mm2. Wilcoxon paired tests were used to compare liver eSNR and IVIM parameters. Inter-platform reproducibility was assessed by calculating within-subject coefficient of variation (CV) and Bland–Altman limits of agreement. An ice water phantom was used to test ADC variability between the two MRI systems.
Results: The mean invitro difference in ADC between the two platforms was 6.8%. eSNR was significantly higher at 3.0T for all selected b values (p = 0.006–0.020), except for b0 (p = 0.239). Liver IVIM parameters were significantly different between 1.5 T and 3.0 T (p = 0.005–0.044), except for ADC (p = 0.748). The inter-platform reproducibility of true diffusion coefficient (D) and ADC were good, with mean CV of 10.9% and 11.1%, respectively. Perfusion fraction (PF) and pseudodiffusion coefficient (D*) showed more limited inter-platform reproducibility (mean CV of 22.6% for PF and 46.9% for D*).
Conclusion: Liver D and ADC values showed good reproducibility between 1.5 T and 3.0 T platforms; while there was more variability in PF, and large variability in D* parameters between the two platforms. These findings may have implications for drug trials assessing the role of IVIM DWI in tumor response and liver fibrosis. |
| first_indexed | 2024-12-12T21:51:00Z |
| format | Article |
| id | doaj.art-d770f425b5154078a668c955b3201da0 |
| institution | Directory Open Access Journal |
| issn | 2352-0477 |
| language | English |
| last_indexed | 2024-12-12T21:51:00Z |
| publishDate | 2015-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | European Journal of Radiology Open |
| spelling | doaj.art-d770f425b5154078a668c955b3201da02022-12-22T00:10:48ZengElsevierEuropean Journal of Radiology Open2352-04772015-01-012C12312810.1016/j.ejro.2015.08.001IVIM diffusion-weighted imaging of the liver at 3.0 T: Comparison with 1.5 TYong CuiHadrien DyvorneCecilia BesaNancy CooperBachir TaouliPurpose: To compare intravoxel incoherent motion (IVIM) diffusion-weighted imaging (DWI) of the liver between 1.5 T and 3.0 T in terms of parameter quantification and inter-platform reproducibility. Materials and methods: In this IRB approved prospective study, 19 subjects (17 patients with chronic liver disease and 2 healthy volunteers) underwent two repeat scans at 1.5 T and 3.0 T. Each scan included IVIM DWI using 16 b values from 0 to 800 s/mm2. A single observer measured IVIM parameters for each platform and estimated signal to noise ratio (eSNR) at b0, 200, 400 and 800 s/mm2. Wilcoxon paired tests were used to compare liver eSNR and IVIM parameters. Inter-platform reproducibility was assessed by calculating within-subject coefficient of variation (CV) and Bland–Altman limits of agreement. An ice water phantom was used to test ADC variability between the two MRI systems. Results: The mean invitro difference in ADC between the two platforms was 6.8%. eSNR was significantly higher at 3.0T for all selected b values (p = 0.006–0.020), except for b0 (p = 0.239). Liver IVIM parameters were significantly different between 1.5 T and 3.0 T (p = 0.005–0.044), except for ADC (p = 0.748). The inter-platform reproducibility of true diffusion coefficient (D) and ADC were good, with mean CV of 10.9% and 11.1%, respectively. Perfusion fraction (PF) and pseudodiffusion coefficient (D*) showed more limited inter-platform reproducibility (mean CV of 22.6% for PF and 46.9% for D*). Conclusion: Liver D and ADC values showed good reproducibility between 1.5 T and 3.0 T platforms; while there was more variability in PF, and large variability in D* parameters between the two platforms. These findings may have implications for drug trials assessing the role of IVIM DWI in tumor response and liver fibrosis.http://www.sciencedirect.com/science/article/pii/S2352047715300046Diffusion-weighted imagingIntravoxel incoherent motion3.0 TLiverReproducibility |
| spellingShingle | Yong Cui Hadrien Dyvorne Cecilia Besa Nancy Cooper Bachir Taouli IVIM diffusion-weighted imaging of the liver at 3.0 T: Comparison with 1.5 T European Journal of Radiology Open Diffusion-weighted imaging Intravoxel incoherent motion 3.0 T Liver Reproducibility |
| title | IVIM diffusion-weighted imaging of the liver at 3.0 T: Comparison with 1.5 T |
| title_full | IVIM diffusion-weighted imaging of the liver at 3.0 T: Comparison with 1.5 T |
| title_fullStr | IVIM diffusion-weighted imaging of the liver at 3.0 T: Comparison with 1.5 T |
| title_full_unstemmed | IVIM diffusion-weighted imaging of the liver at 3.0 T: Comparison with 1.5 T |
| title_short | IVIM diffusion-weighted imaging of the liver at 3.0 T: Comparison with 1.5 T |
| title_sort | ivim diffusion weighted imaging of the liver at 3 0 t comparison with 1 5 t |
| topic | Diffusion-weighted imaging Intravoxel incoherent motion 3.0 T Liver Reproducibility |
| url | http://www.sciencedirect.com/science/article/pii/S2352047715300046 |
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