Plasma myeloperoxidase-conjugated DNA level predicts outcomes and organ dysfunction in patients with septic shock

Plasma myeloperoxidase-conjugated DNA level predicts outcomes and organ dysfunction in patients with septic shock

Abstract Background Recent studies have suggested that excessive formation of neutrophil extracellular traps (NETs) plays a critical role in the pathogenesis of sepsis. Although elevation of the plasma level of cell-free DNA (cf-DNA) has been reported in sepsis patients, there has been little direct...

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Bibliographic Details
Main Authors: Yuki Maruchi, Masanobu Tsuda, Hisatake Mori, Nobuyoshi Takenaka, Takayoshi Gocho, Muhammad A. Huq, Naoshi Takeyama
Format: Article
Language:English
Published: BMC 2018-07-01
Series:Critical Care
Subjects:
Neutrophil extracellular traps
Septic shock
Cell-free DNA
Myeloperoxidase
Neutrophil elastase
SOFA score
Online Access:http://link.springer.com/article/10.1186/s13054-018-2109-7

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