Deficiency of Biogenic Amines Modulates the Activity of Hypoglossal Nerve in the Reserpine Model of Parkinson’s Disease
The underlying cause of respiratory impairments appearing in Parkinson’s disease (PD) is still far from being elucidated. To better understand the pathogenesis of respiratory disorders appearing in PD, we studied hypoglossal (HG) and phrenic (PHR) motoneuron dysfunction in a rat model evoked with re...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-03-01
|
| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/10/3/531 |
| _version_ | 1827604272379854848 |
|---|---|
| author | Monika Jampolska Kryspin Andrzejewski Małgorzata Zaremba Ilona Joniec-Maciejak Katarzyna Kaczyńska |
| author_facet | Monika Jampolska Kryspin Andrzejewski Małgorzata Zaremba Ilona Joniec-Maciejak Katarzyna Kaczyńska |
| author_sort | Monika Jampolska |
| collection | DOAJ |
| description | The underlying cause of respiratory impairments appearing in Parkinson’s disease (PD) is still far from being elucidated. To better understand the pathogenesis of respiratory disorders appearing in PD, we studied hypoglossal (HG) and phrenic (PHR) motoneuron dysfunction in a rat model evoked with reserpine administration. After reserpine, a decrease in the baseline amplitude and minute HG activity was noted, and no depressive phase of the hypoxic ventilatory response was observed. The pre-inspiratory time of HG activity along with the ratio of pre-inspiratory time to total respiratory cycle time and the ratio of pre-inspiratory to inspiratory amplitude were significantly reduced during normoxia, hypoxia, and recovery compared to sham rats. We suggest that the massive depletion of not only dopamine, but above all noradrenaline and serotonin in the brainstem observed in our study, has an impact on the pre-inspiratory activity of the HG. The shortening of the pre-inspiratory activity of the HG in the reserpine model may indicate a serious problem with maintaining the correct diameter of the upper airways in the preparation phase for inspiratory effort and explain the development of obstructive sleep apnea in some PD patients. Therapies involving the supplementation of amine depletion other than dopamine should be considered. |
| first_indexed | 2024-03-09T05:56:40Z |
| format | Article |
| id | doaj.art-d77281e6f08f4564b19e0f0f201f0111 |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-09T05:56:40Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-d77281e6f08f4564b19e0f0f201f01112023-12-03T12:13:05ZengMDPI AGCells2073-44092021-03-0110353110.3390/cells10030531Deficiency of Biogenic Amines Modulates the Activity of Hypoglossal Nerve in the Reserpine Model of Parkinson’s DiseaseMonika Jampolska0Kryspin Andrzejewski1Małgorzata Zaremba2Ilona Joniec-Maciejak3Katarzyna Kaczyńska4Department of Respiration Physiology, Mossakowski Medical Research Institute, Polish Academy of Sciences, 02-106 Warsaw, PolandDepartment of Respiration Physiology, Mossakowski Medical Research Institute, Polish Academy of Sciences, 02-106 Warsaw, PolandDepartment of Experimental and Clinical Pharmacology, Centre for Preclinical Research (CePT), Medical University of Warsaw, 02-091 Warsaw, PolandDepartment of Experimental and Clinical Pharmacology, Centre for Preclinical Research (CePT), Medical University of Warsaw, 02-091 Warsaw, PolandDepartment of Respiration Physiology, Mossakowski Medical Research Institute, Polish Academy of Sciences, 02-106 Warsaw, PolandThe underlying cause of respiratory impairments appearing in Parkinson’s disease (PD) is still far from being elucidated. To better understand the pathogenesis of respiratory disorders appearing in PD, we studied hypoglossal (HG) and phrenic (PHR) motoneuron dysfunction in a rat model evoked with reserpine administration. After reserpine, a decrease in the baseline amplitude and minute HG activity was noted, and no depressive phase of the hypoxic ventilatory response was observed. The pre-inspiratory time of HG activity along with the ratio of pre-inspiratory time to total respiratory cycle time and the ratio of pre-inspiratory to inspiratory amplitude were significantly reduced during normoxia, hypoxia, and recovery compared to sham rats. We suggest that the massive depletion of not only dopamine, but above all noradrenaline and serotonin in the brainstem observed in our study, has an impact on the pre-inspiratory activity of the HG. The shortening of the pre-inspiratory activity of the HG in the reserpine model may indicate a serious problem with maintaining the correct diameter of the upper airways in the preparation phase for inspiratory effort and explain the development of obstructive sleep apnea in some PD patients. Therapies involving the supplementation of amine depletion other than dopamine should be considered.https://www.mdpi.com/2073-4409/10/3/531Parkinson’s diseasesbiogenic aminesreserpine modelhypoxiahypoglossal nervephrenic nerve |
| spellingShingle | Monika Jampolska Kryspin Andrzejewski Małgorzata Zaremba Ilona Joniec-Maciejak Katarzyna Kaczyńska Deficiency of Biogenic Amines Modulates the Activity of Hypoglossal Nerve in the Reserpine Model of Parkinson’s Disease Cells Parkinson’s diseases biogenic amines reserpine model hypoxia hypoglossal nerve phrenic nerve |
| title | Deficiency of Biogenic Amines Modulates the Activity of Hypoglossal Nerve in the Reserpine Model of Parkinson’s Disease |
| title_full | Deficiency of Biogenic Amines Modulates the Activity of Hypoglossal Nerve in the Reserpine Model of Parkinson’s Disease |
| title_fullStr | Deficiency of Biogenic Amines Modulates the Activity of Hypoglossal Nerve in the Reserpine Model of Parkinson’s Disease |
| title_full_unstemmed | Deficiency of Biogenic Amines Modulates the Activity of Hypoglossal Nerve in the Reserpine Model of Parkinson’s Disease |
| title_short | Deficiency of Biogenic Amines Modulates the Activity of Hypoglossal Nerve in the Reserpine Model of Parkinson’s Disease |
| title_sort | deficiency of biogenic amines modulates the activity of hypoglossal nerve in the reserpine model of parkinson s disease |
| topic | Parkinson’s diseases biogenic amines reserpine model hypoxia hypoglossal nerve phrenic nerve |
| url | https://www.mdpi.com/2073-4409/10/3/531 |
| work_keys_str_mv | AT monikajampolska deficiencyofbiogenicaminesmodulatestheactivityofhypoglossalnerveinthereserpinemodelofparkinsonsdisease AT kryspinandrzejewski deficiencyofbiogenicaminesmodulatestheactivityofhypoglossalnerveinthereserpinemodelofparkinsonsdisease AT małgorzatazaremba deficiencyofbiogenicaminesmodulatestheactivityofhypoglossalnerveinthereserpinemodelofparkinsonsdisease AT ilonajoniecmaciejak deficiencyofbiogenicaminesmodulatestheactivityofhypoglossalnerveinthereserpinemodelofparkinsonsdisease AT katarzynakaczynska deficiencyofbiogenicaminesmodulatestheactivityofhypoglossalnerveinthereserpinemodelofparkinsonsdisease |