Telomere fusions as a signal of term placental aging? A pilot study
The placenta plays an essential role at the beginning of life, nourishing and supporting the fetus, but its life span is limited. In late pregnancy, the placenta develops signs of aging, including inflammation and impaired function, which may complicate pregnancy. Placentas also show another sign of...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Bioscientifica
2022-11-01
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| Series: | Reproduction and Fertility |
| Subjects: | |
| Online Access: | https://raf.bioscientifica.com/view/journals/raf/3/4/RAF-22-0065.xml |
| _version_ | 1811213730446311424 |
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| author | Fabiana B Kohlrausch Fang Wang Danxia Luo Rebecca Mahn David L Keefe |
| author_facet | Fabiana B Kohlrausch Fang Wang Danxia Luo Rebecca Mahn David L Keefe |
| author_sort | Fabiana B Kohlrausch |
| collection | DOAJ |
| description | The placenta plays an essential role at the beginning of life, nourishing and supporting the fetus, but its life span is limited. In late pregnancy, the placenta develops signs of aging, including inflammation and impaired function, which may complicate pregnancy. Placentas also show another sign of aging – cells with extra or missing chromosomes. Chromosomally abnormal cells could gather in the placenta if they get stranded there and/or if the cells do not separate normally. Chromosome separation goes wrong in aging cells when the DNA sequences, which protect the ends of the chromosomes, erode. When chromosomes lose their protective caps, they fuse which leads to abnormal numbers of chromosomes. In this pilot study, for the first time, we found fusions between the caps in a human placenta when it reaches full term. More studies are needed to decide whether this has an influence on how the placenta works and outcomes of pregnancy. |
| first_indexed | 2024-04-12T05:51:03Z |
| format | Article |
| id | doaj.art-d775b9e0216b4df58c6c759ec960f49f |
| institution | Directory Open Access Journal |
| issn | 2633-8386 |
| language | English |
| last_indexed | 2024-04-12T05:51:03Z |
| publishDate | 2022-11-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Reproduction and Fertility |
| spelling | doaj.art-d775b9e0216b4df58c6c759ec960f49f2022-12-22T03:45:18ZengBioscientificaReproduction and Fertility2633-83862022-11-0134L9L11https://doi.org/10.1530/RAF-22-0065Telomere fusions as a signal of term placental aging? A pilot studyFabiana B Kohlrausch0Fang Wang1Danxia Luo2Rebecca Mahn3David L Keefe4Departamento de Biologia Geral, Universidade Federal Fluminense, Niterói, Rio de Janeiro, Brasil; Department of Obstetrics and Gynecology, New York University, Langone Medical Center, New York, New York, USA Department of Obstetrics and Gynecology, New York University, Langone Medical Center, New York, New York, USADepartment of Obstetrics and Gynecology, New York University, Langone Medical Center, New York, New York, USADepartment of Obstetrics and Gynecology, New York University, Langone Medical Center, New York, New York, USADepartment of Obstetrics and Gynecology, New York University, Langone Medical Center, New York, New York, USAThe placenta plays an essential role at the beginning of life, nourishing and supporting the fetus, but its life span is limited. In late pregnancy, the placenta develops signs of aging, including inflammation and impaired function, which may complicate pregnancy. Placentas also show another sign of aging – cells with extra or missing chromosomes. Chromosomally abnormal cells could gather in the placenta if they get stranded there and/or if the cells do not separate normally. Chromosome separation goes wrong in aging cells when the DNA sequences, which protect the ends of the chromosomes, erode. When chromosomes lose their protective caps, they fuse which leads to abnormal numbers of chromosomes. In this pilot study, for the first time, we found fusions between the caps in a human placenta when it reaches full term. More studies are needed to decide whether this has an influence on how the placenta works and outcomes of pregnancy.https://raf.bioscientifica.com/view/journals/raf/3/4/RAF-22-0065.xmlplacentahescgenomic instabilitytelomerefusion |
| spellingShingle | Fabiana B Kohlrausch Fang Wang Danxia Luo Rebecca Mahn David L Keefe Telomere fusions as a signal of term placental aging? A pilot study Reproduction and Fertility placenta hesc genomic instability telomere fusion |
| title | Telomere fusions as a signal of term placental aging? A pilot study |
| title_full | Telomere fusions as a signal of term placental aging? A pilot study |
| title_fullStr | Telomere fusions as a signal of term placental aging? A pilot study |
| title_full_unstemmed | Telomere fusions as a signal of term placental aging? A pilot study |
| title_short | Telomere fusions as a signal of term placental aging? A pilot study |
| title_sort | telomere fusions as a signal of term placental aging a pilot study |
| topic | placenta hesc genomic instability telomere fusion |
| url | https://raf.bioscientifica.com/view/journals/raf/3/4/RAF-22-0065.xml |
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