Discrimination between Pancreatic Cancer, Pancreatitis and Healthy Controls Using Urinary Polyamine Panel
Backround Polyamines play an important role in cellular proliferation, and the change in polyamine metabolism is reported in various cancers. We searched for urinary polyamine signature for distinguishing between pancreatic cancer, premalignant lesions of the pancreas (PLP), acute and chronic pancre...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2021-10-01
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| Series: | Cancer Control |
| Online Access: | https://doi.org/10.1177/10732748211039762 |
| _version_ | 1818331366679379968 |
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| author | Samuli I. Nissinen MD Markus Venäläinen MD Pekka Kumpulainen DSc Antti Roine MD, PhD Merja R. Häkkinen PhD Jouko Vepsäläinen PhD Niku Oksala MD, PhD Tuomo Rantanen MD, PhD |
| author_facet | Samuli I. Nissinen MD Markus Venäläinen MD Pekka Kumpulainen DSc Antti Roine MD, PhD Merja R. Häkkinen PhD Jouko Vepsäläinen PhD Niku Oksala MD, PhD Tuomo Rantanen MD, PhD |
| author_sort | Samuli I. Nissinen MD |
| collection | DOAJ |
| description | Backround Polyamines play an important role in cellular proliferation, and the change in polyamine metabolism is reported in various cancers. We searched for urinary polyamine signature for distinguishing between pancreatic cancer, premalignant lesions of the pancreas (PLP), acute and chronic pancreatitis, and controls. Methods Patients and controls were prospectively recruited in three Finnish hospitals between October 2013 and June 2016. The patients provided a urine sample at the time of the diagnosis. The panel of 14 polyamines was obtained in a single run with mass spectrometry. The polyamine concentrations were analysed with quadratic discriminant analysis and cross-validated with leave-one-out cross-validation. Results Sixty-eight patients with pancreatic cancer, 36 with acute pancreatitis, 18 with chronic pancreatitis and 7 with PLP were recruited, as were 53 controls. The combination of 4 polyamines – acetylputrescine, diacetylspermidine, N 8 -acetylspermidine and diacetylputrescine – distinguished pancreatic cancer and PLP from controls (sensitivity = 94%, specificity = 68% and AUC = 0.88). The combination of diacetylspermidine, N8-acetylspermidine and diacetylspermine distinguished acute pancreatitis from controls (sensitivity = 94%, specificity = 92%, AUC = 0.98). The combination of acetylputrescine, diacetylspermidine and diacetylputrescine distinguished chronic pancreatitis from controls (sensitivity = 98%, specificity = 71%, AUC = 0.93). Conclusions Optimally selected urinary polyamine panels discriminate between pancreatic cancer and controls, as well as between acute and chronic pancreatitis and controls. |
| first_indexed | 2024-12-13T13:18:43Z |
| format | Article |
| id | doaj.art-d776371d2e40453f82fb01010496060c |
| institution | Directory Open Access Journal |
| issn | 1073-2748 |
| language | English |
| last_indexed | 2024-12-13T13:18:43Z |
| publishDate | 2021-10-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Cancer Control |
| spelling | doaj.art-d776371d2e40453f82fb01010496060c2022-12-21T23:44:28ZengSAGE PublishingCancer Control1073-27482021-10-012810.1177/10732748211039762Discrimination between Pancreatic Cancer, Pancreatitis and Healthy Controls Using Urinary Polyamine PanelSamuli I. Nissinen MDMarkus Venäläinen MDPekka Kumpulainen DScAntti Roine MD, PhDMerja R. Häkkinen PhDJouko Vepsäläinen PhDNiku Oksala MD, PhDTuomo Rantanen MD, PhDBackround Polyamines play an important role in cellular proliferation, and the change in polyamine metabolism is reported in various cancers. We searched for urinary polyamine signature for distinguishing between pancreatic cancer, premalignant lesions of the pancreas (PLP), acute and chronic pancreatitis, and controls. Methods Patients and controls were prospectively recruited in three Finnish hospitals between October 2013 and June 2016. The patients provided a urine sample at the time of the diagnosis. The panel of 14 polyamines was obtained in a single run with mass spectrometry. The polyamine concentrations were analysed with quadratic discriminant analysis and cross-validated with leave-one-out cross-validation. Results Sixty-eight patients with pancreatic cancer, 36 with acute pancreatitis, 18 with chronic pancreatitis and 7 with PLP were recruited, as were 53 controls. The combination of 4 polyamines – acetylputrescine, diacetylspermidine, N 8 -acetylspermidine and diacetylputrescine – distinguished pancreatic cancer and PLP from controls (sensitivity = 94%, specificity = 68% and AUC = 0.88). The combination of diacetylspermidine, N8-acetylspermidine and diacetylspermine distinguished acute pancreatitis from controls (sensitivity = 94%, specificity = 92%, AUC = 0.98). The combination of acetylputrescine, diacetylspermidine and diacetylputrescine distinguished chronic pancreatitis from controls (sensitivity = 98%, specificity = 71%, AUC = 0.93). Conclusions Optimally selected urinary polyamine panels discriminate between pancreatic cancer and controls, as well as between acute and chronic pancreatitis and controls.https://doi.org/10.1177/10732748211039762 |
| spellingShingle | Samuli I. Nissinen MD Markus Venäläinen MD Pekka Kumpulainen DSc Antti Roine MD, PhD Merja R. Häkkinen PhD Jouko Vepsäläinen PhD Niku Oksala MD, PhD Tuomo Rantanen MD, PhD Discrimination between Pancreatic Cancer, Pancreatitis and Healthy Controls Using Urinary Polyamine Panel Cancer Control |
| title | Discrimination between Pancreatic Cancer, Pancreatitis and Healthy Controls Using Urinary Polyamine Panel |
| title_full | Discrimination between Pancreatic Cancer, Pancreatitis and Healthy Controls Using Urinary Polyamine Panel |
| title_fullStr | Discrimination between Pancreatic Cancer, Pancreatitis and Healthy Controls Using Urinary Polyamine Panel |
| title_full_unstemmed | Discrimination between Pancreatic Cancer, Pancreatitis and Healthy Controls Using Urinary Polyamine Panel |
| title_short | Discrimination between Pancreatic Cancer, Pancreatitis and Healthy Controls Using Urinary Polyamine Panel |
| title_sort | discrimination between pancreatic cancer pancreatitis and healthy controls using urinary polyamine panel |
| url | https://doi.org/10.1177/10732748211039762 |
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