Importance of Metalloproteinase Enzyme Group in Selected Skeletal System Diseases
Bone tissue is a dynamic structure that is involved in maintaining the homeostasis of the body due to its multidirectional functions, such as its protective, endocrine, or immunological role. Specialized cells and the extracellular matrix (ECM) are responsible for the remodeling of specific bone str...
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| Format: | Article |
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MDPI AG
2023-12-01
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| Series: | International Journal of Molecular Sciences |
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| Online Access: | https://www.mdpi.com/1422-0067/24/24/17139 |
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| author | Monika Kulesza Aleksandra Kicman Joanna Motyka Tomasz Guszczyn Sławomir Ławicki |
| author_facet | Monika Kulesza Aleksandra Kicman Joanna Motyka Tomasz Guszczyn Sławomir Ławicki |
| author_sort | Monika Kulesza |
| collection | DOAJ |
| description | Bone tissue is a dynamic structure that is involved in maintaining the homeostasis of the body due to its multidirectional functions, such as its protective, endocrine, or immunological role. Specialized cells and the extracellular matrix (ECM) are responsible for the remodeling of specific bone structures, which alters the biomechanical properties of the tissue. Imbalances in bone-forming elements lead to the formation and progression of bone diseases. The most important family of enzymes responsible for bone ECM remodeling are matrix metalloproteinases (MMPs)—enzymes physiologically present in the body’s tissues and cells. The activity of MMPs is maintained in a state of balance; disruption of their activity is associated with the progression of many groups of diseases, including those of the skeletal system. This review summarizes the current understanding of the role of MMPs in bone physiology and the pathophysiology of bone tissue and describes their role in specific skeletal disorders. Additionally, this work collects data on the potential of MMPs as bio-markers for specific skeletal diseases. |
| first_indexed | 2024-03-08T20:43:13Z |
| format | Article |
| id | doaj.art-d77660bc58ec45c9b98e8314e0a60967 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-08T20:43:13Z |
| publishDate | 2023-12-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-d77660bc58ec45c9b98e8314e0a609672023-12-22T14:13:22ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-12-0124241713910.3390/ijms242417139Importance of Metalloproteinase Enzyme Group in Selected Skeletal System DiseasesMonika Kulesza0Aleksandra Kicman1Joanna Motyka2Tomasz Guszczyn3Sławomir Ławicki4Department of Population Medicine and Lifestyle Diseases Prevention, Medical University of Bialystok, 15269 Bialystok, PolandDepartment of Aesthetic Medicine, Medical University of Bialystok, 15267 Bialystok, PolandDepartment of Population Medicine and Lifestyle Diseases Prevention, Medical University of Bialystok, 15269 Bialystok, PolandDepartment of Pediatric Orthopaedics and Traumatology, Medical University of Bialystok, 15274 Bialystok, PolandDepartment of Population Medicine and Lifestyle Diseases Prevention, Medical University of Bialystok, 15269 Bialystok, PolandBone tissue is a dynamic structure that is involved in maintaining the homeostasis of the body due to its multidirectional functions, such as its protective, endocrine, or immunological role. Specialized cells and the extracellular matrix (ECM) are responsible for the remodeling of specific bone structures, which alters the biomechanical properties of the tissue. Imbalances in bone-forming elements lead to the formation and progression of bone diseases. The most important family of enzymes responsible for bone ECM remodeling are matrix metalloproteinases (MMPs)—enzymes physiologically present in the body’s tissues and cells. The activity of MMPs is maintained in a state of balance; disruption of their activity is associated with the progression of many groups of diseases, including those of the skeletal system. This review summarizes the current understanding of the role of MMPs in bone physiology and the pathophysiology of bone tissue and describes their role in specific skeletal disorders. Additionally, this work collects data on the potential of MMPs as bio-markers for specific skeletal diseases.https://www.mdpi.com/1422-0067/24/24/17139metalloproteinasesskeletal system diseasesbone tumorsosteoporosisintervertebral disc degeneration |
| spellingShingle | Monika Kulesza Aleksandra Kicman Joanna Motyka Tomasz Guszczyn Sławomir Ławicki Importance of Metalloproteinase Enzyme Group in Selected Skeletal System Diseases International Journal of Molecular Sciences metalloproteinases skeletal system diseases bone tumors osteoporosis intervertebral disc degeneration |
| title | Importance of Metalloproteinase Enzyme Group in Selected Skeletal System Diseases |
| title_full | Importance of Metalloproteinase Enzyme Group in Selected Skeletal System Diseases |
| title_fullStr | Importance of Metalloproteinase Enzyme Group in Selected Skeletal System Diseases |
| title_full_unstemmed | Importance of Metalloproteinase Enzyme Group in Selected Skeletal System Diseases |
| title_short | Importance of Metalloproteinase Enzyme Group in Selected Skeletal System Diseases |
| title_sort | importance of metalloproteinase enzyme group in selected skeletal system diseases |
| topic | metalloproteinases skeletal system diseases bone tumors osteoporosis intervertebral disc degeneration |
| url | https://www.mdpi.com/1422-0067/24/24/17139 |
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