Inhibition of exosome biogenesis affects cell motility in heterogeneous sub-populations of paediatric-type diffuse high-grade gliomas

Inhibition of exosome biogenesis affects cell motility in heterogeneous sub-populations of paediatric-type diffuse high-grade gliomas

Abstract Background Paediatric-type diffuse High-Grade Gliomas (PDHGG) are highly heterogeneous tumours which include distinct cell sub-populations co-existing within the same tumour mass. We have previously shown that primary patient-derived and optical barcoded single-cell-derived clones function...

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Main Authors: Giulia Pericoli, Angela Galardi, Alessandro Paolini, Lucia Lisa Petrilli, Gerardo Pepe, Alessandro Palma, Marta Colletti, Roberta Ferretti, Ezio Giorda, Stefano Levi Mortera, Anna Burford, Andrea Carai, Angela Mastronuzzi, Alan Mackay, Lorenza Putignani, Chris Jones, Luisa Pascucci, Hector Peinado, Manuela Helmer-Citterich, Emmanuel de Billy, Andrea Masotti, Franco Locatelli, Angela Di Giannatale, Maria Vinci
Format: Article
Language:English
Published: BMC 2023-11-01
Series:Cell & Bioscience
Subjects:
Paediatric-type diffuse high-grade glioma
DIPG
GBM
Heterogeneity
Cell communication
Exosome
Online Access:https://doi.org/10.1186/s13578-023-01166-5

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