Mesenchymal Stem Cell-Derived Exosomes in Cardioprotection: A Novel Application to Prevent Myocardial Injury
Perioperative myocardial injury is a common complication caused by major surgery. Many pharmacological and nonpharmacological studies have investigated perioperative cardioprotection. However, the methods are insufficient to meet the increasing clinical needs for cardioprotection. The application of...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
IMR Press
2022-09-01
|
| Series: | Reviews in Cardiovascular Medicine |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/RCM/23/9/10.31083/j.rcm2309310 |
| _version_ | 1811209251136208896 |
|---|---|
| author | Shaokang Yang Jialin Li Mingbo Tang Xinliang Gao Wei Liu Shixiong Wei |
| author_facet | Shaokang Yang Jialin Li Mingbo Tang Xinliang Gao Wei Liu Shixiong Wei |
| author_sort | Shaokang Yang |
| collection | DOAJ |
| description | Perioperative myocardial injury is a common complication caused by major surgery. Many pharmacological and nonpharmacological studies have investigated perioperative cardioprotection. However, the methods are insufficient to meet the increasing clinical needs for cardioprotection. The application of Mesenchymal Stem Cell-Derived Exosomes (MSC-Exos) is a novel cell-free therapeutic strategy and has significantly benefitted patients suffering from various diseases. In this review, we comprehensively analyzed the application of MSC-Exos to prevent myocardial infarction/injury by regulating inflammatory reactions, inhibiting cardiomyocyte apoptosis and autophagy, promoting angiogenesis, and mediating cardiac remodeling. Finally, we assessed the therapeutic effects and the challenges associated with the application of MSC-Exos from a clinical perspective. |
| first_indexed | 2024-04-12T04:35:05Z |
| format | Article |
| id | doaj.art-d778ea631fdf40dba563bb921c3329d2 |
| institution | Directory Open Access Journal |
| issn | 1530-6550 |
| language | English |
| last_indexed | 2024-04-12T04:35:05Z |
| publishDate | 2022-09-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Reviews in Cardiovascular Medicine |
| spelling | doaj.art-d778ea631fdf40dba563bb921c3329d22022-12-22T03:47:49ZengIMR PressReviews in Cardiovascular Medicine1530-65502022-09-0123931010.31083/j.rcm2309310S1530-6550(22)00635-4Mesenchymal Stem Cell-Derived Exosomes in Cardioprotection: A Novel Application to Prevent Myocardial InjuryShaokang Yang0Jialin Li1Mingbo Tang2Xinliang Gao3Wei Liu4Shixiong Wei5Department of Gastric and Colorectal Surgery, General Surgery Center, The First Hospital of Jilin University, 130021 Changchun, Jilin, ChinaDepartment of Thoracic Surgery, The First Hospital of Jilin University, 130021 Changchun, Jilin, ChinaDepartment of Thoracic Surgery, The First Hospital of Jilin University, 130021 Changchun, Jilin, ChinaDepartment of Thoracic Surgery, The First Hospital of Jilin University, 130021 Changchun, Jilin, ChinaDepartment of Thoracic Surgery, The First Hospital of Jilin University, 130021 Changchun, Jilin, ChinaDepartment of Thoracic Surgery, The First Hospital of Jilin University, 130021 Changchun, Jilin, ChinaPerioperative myocardial injury is a common complication caused by major surgery. Many pharmacological and nonpharmacological studies have investigated perioperative cardioprotection. However, the methods are insufficient to meet the increasing clinical needs for cardioprotection. The application of Mesenchymal Stem Cell-Derived Exosomes (MSC-Exos) is a novel cell-free therapeutic strategy and has significantly benefitted patients suffering from various diseases. In this review, we comprehensively analyzed the application of MSC-Exos to prevent myocardial infarction/injury by regulating inflammatory reactions, inhibiting cardiomyocyte apoptosis and autophagy, promoting angiogenesis, and mediating cardiac remodeling. Finally, we assessed the therapeutic effects and the challenges associated with the application of MSC-Exos from a clinical perspective.https://www.imrpress.com/journal/RCM/23/9/10.31083/j.rcm2309310mesenchymal stem cellexosomescardioprotectionmyocardial injury |
| spellingShingle | Shaokang Yang Jialin Li Mingbo Tang Xinliang Gao Wei Liu Shixiong Wei Mesenchymal Stem Cell-Derived Exosomes in Cardioprotection: A Novel Application to Prevent Myocardial Injury Reviews in Cardiovascular Medicine mesenchymal stem cell exosomes cardioprotection myocardial injury |
| title | Mesenchymal Stem Cell-Derived Exosomes in Cardioprotection: A Novel Application to Prevent Myocardial Injury |
| title_full | Mesenchymal Stem Cell-Derived Exosomes in Cardioprotection: A Novel Application to Prevent Myocardial Injury |
| title_fullStr | Mesenchymal Stem Cell-Derived Exosomes in Cardioprotection: A Novel Application to Prevent Myocardial Injury |
| title_full_unstemmed | Mesenchymal Stem Cell-Derived Exosomes in Cardioprotection: A Novel Application to Prevent Myocardial Injury |
| title_short | Mesenchymal Stem Cell-Derived Exosomes in Cardioprotection: A Novel Application to Prevent Myocardial Injury |
| title_sort | mesenchymal stem cell derived exosomes in cardioprotection a novel application to prevent myocardial injury |
| topic | mesenchymal stem cell exosomes cardioprotection myocardial injury |
| url | https://www.imrpress.com/journal/RCM/23/9/10.31083/j.rcm2309310 |
| work_keys_str_mv | AT shaokangyang mesenchymalstemcellderivedexosomesincardioprotectionanovelapplicationtopreventmyocardialinjury AT jialinli mesenchymalstemcellderivedexosomesincardioprotectionanovelapplicationtopreventmyocardialinjury AT mingbotang mesenchymalstemcellderivedexosomesincardioprotectionanovelapplicationtopreventmyocardialinjury AT xinlianggao mesenchymalstemcellderivedexosomesincardioprotectionanovelapplicationtopreventmyocardialinjury AT weiliu mesenchymalstemcellderivedexosomesincardioprotectionanovelapplicationtopreventmyocardialinjury AT shixiongwei mesenchymalstemcellderivedexosomesincardioprotectionanovelapplicationtopreventmyocardialinjury |