Changes in Gut Microbiota Correlates with Response to Treatment with Probiotics in Patients with Atopic Dermatitis. A Post Hoc Analysis of a Clinical Trial
Atopic dermatitis (AD) is a chronic recurrent inflammatory skin disease with a high impact on the comfort of those who are affected and long-term treated with corticosteroids with limited efficacy and a high prevalence of relapses. Because of the limited effectiveness of these treatments, new strate...
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| Format: | Article |
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MDPI AG
2021-04-01
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| Series: | Microorganisms |
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| Online Access: | https://www.mdpi.com/2076-2607/9/4/854 |
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| author | Eric Climent Juan Francisco Martinez-Blanch Laura Llobregat Beatriz Ruzafa-Costas Miguel Ángel Carrión-Gutiérrez Ana Ramírez-Boscá David Prieto-Merino Salvador Genovés Francisco M. Codoñer Daniel Ramón Empar Chenoll Vicente Navarro-López |
| author_facet | Eric Climent Juan Francisco Martinez-Blanch Laura Llobregat Beatriz Ruzafa-Costas Miguel Ángel Carrión-Gutiérrez Ana Ramírez-Boscá David Prieto-Merino Salvador Genovés Francisco M. Codoñer Daniel Ramón Empar Chenoll Vicente Navarro-López |
| author_sort | Eric Climent |
| collection | DOAJ |
| description | Atopic dermatitis (AD) is a chronic recurrent inflammatory skin disease with a high impact on the comfort of those who are affected and long-term treated with corticosteroids with limited efficacy and a high prevalence of relapses. Because of the limited effectiveness of these treatments, new strategies for recovery from AD lesions are continually being explored. In this article, we describe the gut microbiome changes achieved in a recently published clinical trial with the probiotic formulation <i>Bifidobacterium animalis</i> subsp. <i>lactis</i> CECT 8145, <i>Bifidobacterium longum</i> CECT 7347, and <i>Lacticaseibacillus casei</i> CECT 9104 (formerly <i>Lactobacillus casei</i> CECT 9104), showing a significant improvement in SCORAD (scoring atopic dermatitis) index in children (4–17 years) with AD (Clinicaltrials.gov identifier: NCT02585986). The present gut microbiome post hoc study showed no significant changes in diversity (Shannon and Simpson indexes) after probiotic consumption. In the probiotic group, genera <i>Bacteroides, Ruminococcus</i>, and <i>Bifidobacterium</i> significantly increased their levels while <i>Faecalibacterium</i> decreased, compared to the placebo group. <i>Faecalibacterium</i> showed the highest presence and significant positive correlation with AD severity (SCORAD index), whereas <i>Abyssivirga, Bifidobacterium,</i> and <i>Lactococcus</i> were inversely correlated. The results suggest that the consumption of the probiotic formulation here assayed modulates the gut microbiome with significant changes in genera <i>Bacteroides</i> and <i>Faecalibacterium</i>. In turn, the improvement in SCORAD correlates with a decrease in <i>Faecalibacterium</i> and an increase in <i>Bifidobacterium</i>, among others. |
| first_indexed | 2024-03-10T12:17:45Z |
| format | Article |
| id | doaj.art-d77b568a82f64dafa1fc62a1ba3467b5 |
| institution | Directory Open Access Journal |
| issn | 2076-2607 |
| language | English |
| last_indexed | 2024-03-10T12:17:45Z |
| publishDate | 2021-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Microorganisms |
| spelling | doaj.art-d77b568a82f64dafa1fc62a1ba3467b52023-11-21T15:46:40ZengMDPI AGMicroorganisms2076-26072021-04-019485410.3390/microorganisms9040854Changes in Gut Microbiota Correlates with Response to Treatment with Probiotics in Patients with Atopic Dermatitis. A Post Hoc Analysis of a Clinical TrialEric Climent0Juan Francisco Martinez-Blanch1Laura Llobregat2Beatriz Ruzafa-Costas3Miguel Ángel Carrión-Gutiérrez4Ana Ramírez-Boscá5David Prieto-Merino6Salvador Genovés7Francisco M. Codoñer8Daniel Ramón9Empar Chenoll10Vicente Navarro-López11Biopolis S.L.-ADM, Catedrático Agustín Escardino Benlloch 9 Edif. 2, 46980 Paterna, SpainBiopolis S.L.-ADM, Catedrático Agustín Escardino Benlloch 9 Edif. 2, 46980 Paterna, SpainBiopolis S.L.-ADM, Catedrático Agustín Escardino Benlloch 9 Edif. 2, 46980 Paterna, SpainDepartment of Clinical Medicine, Universidad Católica San Antonio de Murcia (UCAM), 30107 Murcia, SpainEspecialida des Farmacéuticas Centrum, Calle Sagitario 14, 03006 Alicante, SpainDepartment of Clinical Medicine, Universidad Católica San Antonio de Murcia (UCAM), 30107 Murcia, SpainApplied Statistical Methods in Medical Research Group, Universidad Católica San Antonio de Murcia (UCAM), 30107 Murcia, SpainBiopolis S.L.-ADM, Catedrático Agustín Escardino Benlloch 9 Edif. 2, 46980 Paterna, SpainBiopolis S.L.-ADM, Catedrático Agustín Escardino Benlloch 9 Edif. 2, 46980 Paterna, SpainBiopolis S.L.-ADM, Catedrático Agustín Escardino Benlloch 9 Edif. 2, 46980 Paterna, SpainBiopolis S.L.-ADM, Catedrático Agustín Escardino Benlloch 9 Edif. 2, 46980 Paterna, SpainDepartment of Clinical Medicine, Universidad Católica San Antonio de Murcia (UCAM), 30107 Murcia, SpainAtopic dermatitis (AD) is a chronic recurrent inflammatory skin disease with a high impact on the comfort of those who are affected and long-term treated with corticosteroids with limited efficacy and a high prevalence of relapses. Because of the limited effectiveness of these treatments, new strategies for recovery from AD lesions are continually being explored. In this article, we describe the gut microbiome changes achieved in a recently published clinical trial with the probiotic formulation <i>Bifidobacterium animalis</i> subsp. <i>lactis</i> CECT 8145, <i>Bifidobacterium longum</i> CECT 7347, and <i>Lacticaseibacillus casei</i> CECT 9104 (formerly <i>Lactobacillus casei</i> CECT 9104), showing a significant improvement in SCORAD (scoring atopic dermatitis) index in children (4–17 years) with AD (Clinicaltrials.gov identifier: NCT02585986). The present gut microbiome post hoc study showed no significant changes in diversity (Shannon and Simpson indexes) after probiotic consumption. In the probiotic group, genera <i>Bacteroides, Ruminococcus</i>, and <i>Bifidobacterium</i> significantly increased their levels while <i>Faecalibacterium</i> decreased, compared to the placebo group. <i>Faecalibacterium</i> showed the highest presence and significant positive correlation with AD severity (SCORAD index), whereas <i>Abyssivirga, Bifidobacterium,</i> and <i>Lactococcus</i> were inversely correlated. The results suggest that the consumption of the probiotic formulation here assayed modulates the gut microbiome with significant changes in genera <i>Bacteroides</i> and <i>Faecalibacterium</i>. In turn, the improvement in SCORAD correlates with a decrease in <i>Faecalibacterium</i> and an increase in <i>Bifidobacterium</i>, among others.https://www.mdpi.com/2076-2607/9/4/854atopic dermatitisgut-skin axismicrobiomeprobiotics<i>Faecalibacterium</i><i>Bifidobacterium</i> |
| spellingShingle | Eric Climent Juan Francisco Martinez-Blanch Laura Llobregat Beatriz Ruzafa-Costas Miguel Ángel Carrión-Gutiérrez Ana Ramírez-Boscá David Prieto-Merino Salvador Genovés Francisco M. Codoñer Daniel Ramón Empar Chenoll Vicente Navarro-López Changes in Gut Microbiota Correlates with Response to Treatment with Probiotics in Patients with Atopic Dermatitis. A Post Hoc Analysis of a Clinical Trial Microorganisms atopic dermatitis gut-skin axis microbiome probiotics <i>Faecalibacterium</i> <i>Bifidobacterium</i> |
| title | Changes in Gut Microbiota Correlates with Response to Treatment with Probiotics in Patients with Atopic Dermatitis. A Post Hoc Analysis of a Clinical Trial |
| title_full | Changes in Gut Microbiota Correlates with Response to Treatment with Probiotics in Patients with Atopic Dermatitis. A Post Hoc Analysis of a Clinical Trial |
| title_fullStr | Changes in Gut Microbiota Correlates with Response to Treatment with Probiotics in Patients with Atopic Dermatitis. A Post Hoc Analysis of a Clinical Trial |
| title_full_unstemmed | Changes in Gut Microbiota Correlates with Response to Treatment with Probiotics in Patients with Atopic Dermatitis. A Post Hoc Analysis of a Clinical Trial |
| title_short | Changes in Gut Microbiota Correlates with Response to Treatment with Probiotics in Patients with Atopic Dermatitis. A Post Hoc Analysis of a Clinical Trial |
| title_sort | changes in gut microbiota correlates with response to treatment with probiotics in patients with atopic dermatitis a post hoc analysis of a clinical trial |
| topic | atopic dermatitis gut-skin axis microbiome probiotics <i>Faecalibacterium</i> <i>Bifidobacterium</i> |
| url | https://www.mdpi.com/2076-2607/9/4/854 |
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