Die Another Way: Interplay between Influenza A Virus, Inflammation and Cell Death
Influenza A virus (IAV) is a major concern to human health due to the ongoing global threat of a pandemic. Inflammatory and cell death signalling pathways play important roles in host defence against IAV infection. However, severe IAV infections in humans are characterised by excessive inflammation...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-04-01
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| Series: | Viruses |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1999-4915/12/4/401 |
| _version_ | 1827719306441392128 |
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| author | Gabriel Laghlali Kate E. Lawlor Michelle D. Tate |
| author_facet | Gabriel Laghlali Kate E. Lawlor Michelle D. Tate |
| author_sort | Gabriel Laghlali |
| collection | DOAJ |
| description | Influenza A virus (IAV) is a major concern to human health due to the ongoing global threat of a pandemic. Inflammatory and cell death signalling pathways play important roles in host defence against IAV infection. However, severe IAV infections in humans are characterised by excessive inflammation and tissue damage, often leading to fatal disease. While the molecular mechanisms involved in the induction of inflammation during IAV infection have been well studied, the pathways involved in IAV-induced cell death and their impact on immunopathology have not been fully elucidated. There is increasing evidence of significant crosstalk between cell death and inflammatory pathways and a greater understanding of their role in host defence and disease may facilitate the design of new treatments for IAV infection. |
| first_indexed | 2024-03-10T20:40:28Z |
| format | Article |
| id | doaj.art-d77c2339f0604751bb21afffd00f715b |
| institution | Directory Open Access Journal |
| issn | 1999-4915 |
| language | English |
| last_indexed | 2024-03-10T20:40:28Z |
| publishDate | 2020-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Viruses |
| spelling | doaj.art-d77c2339f0604751bb21afffd00f715b2023-11-19T20:44:36ZengMDPI AGViruses1999-49152020-04-0112440110.3390/v12040401Die Another Way: Interplay between Influenza A Virus, Inflammation and Cell DeathGabriel Laghlali0Kate E. Lawlor1Michelle D. Tate2Centre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC 3168, AustraliaCentre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC 3168, AustraliaCentre for Innate Immunity and Infectious Diseases, Hudson Institute of Medical Research, Clayton, VIC 3168, AustraliaInfluenza A virus (IAV) is a major concern to human health due to the ongoing global threat of a pandemic. Inflammatory and cell death signalling pathways play important roles in host defence against IAV infection. However, severe IAV infections in humans are characterised by excessive inflammation and tissue damage, often leading to fatal disease. While the molecular mechanisms involved in the induction of inflammation during IAV infection have been well studied, the pathways involved in IAV-induced cell death and their impact on immunopathology have not been fully elucidated. There is increasing evidence of significant crosstalk between cell death and inflammatory pathways and a greater understanding of their role in host defence and disease may facilitate the design of new treatments for IAV infection.https://www.mdpi.com/1999-4915/12/4/401Influenza A viruscell deathinflammationpathogenesis |
| spellingShingle | Gabriel Laghlali Kate E. Lawlor Michelle D. Tate Die Another Way: Interplay between Influenza A Virus, Inflammation and Cell Death Viruses Influenza A virus cell death inflammation pathogenesis |
| title | Die Another Way: Interplay between Influenza A Virus, Inflammation and Cell Death |
| title_full | Die Another Way: Interplay between Influenza A Virus, Inflammation and Cell Death |
| title_fullStr | Die Another Way: Interplay between Influenza A Virus, Inflammation and Cell Death |
| title_full_unstemmed | Die Another Way: Interplay between Influenza A Virus, Inflammation and Cell Death |
| title_short | Die Another Way: Interplay between Influenza A Virus, Inflammation and Cell Death |
| title_sort | die another way interplay between influenza a virus inflammation and cell death |
| topic | Influenza A virus cell death inflammation pathogenesis |
| url | https://www.mdpi.com/1999-4915/12/4/401 |
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