Behavioural multigenerational effects induced by the administration of very low doses of zinc during pregnancy, lactation, and prepuberal period in the rat
In studies from this laboratory, the chronic administration of ZnTe during pregnancy, lactation, and prepuberal stages of litter (F1 generation) modified the behavioral patterns of motivated exploration, lateralized exploration, social activity, and survival responses of maturing rats. To determine...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-03-01
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| Series: | Journal of Neurorestoratology |
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| Online Access: | https://www.sciopen.com/article/10.26599/JNR.2021.9040004 |
| _version_ | 1797706084787421184 |
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| author | Silvia G. Ratti Osvaldo J. Sacchi Edgardo O. Alvarez |
| author_facet | Silvia G. Ratti Osvaldo J. Sacchi Edgardo O. Alvarez |
| author_sort | Silvia G. Ratti |
| collection | DOAJ |
| description | In studies from this laboratory, the chronic administration of ZnTe during pregnancy, lactation, and prepuberal stages of litter (F1 generation) modified the behavioral patterns of motivated exploration, lateralized exploration, social activity, and survival responses of maturing rats. To determine whether these affected behaviors would extend to the next generation, F1 litter rats previously exposed to tellurium (Te) up to 30-day-old were left at rest with no further treatment up to 90-day-old. Then, F1 female rats were mated with normal untreated male rats, and in the next generation (F2), the litter rats at 30-day-old preserved the modified behaviors previously observed in their parents. The study revealed that Te effects were intergenerational. Here, considering that ZnTe was used in the previous study and that Zn ion has many physiological functions in the cell, experiments were conducted to elucidate if Zn would have an intergenerational effect similar to Te. Working with the same experimental setup as in the previous study but using ZnCl2 instead of ZnTe, results revealed that none of the behavioral responses studied were affected by the F1 generation. However, in the F2 generation, lateralized exploration and survival behavior were inhibited, suggesting that Zn also has an intergenerational effect. |
| first_indexed | 2024-03-12T05:45:59Z |
| format | Article |
| id | doaj.art-d77c7053327c4eebbf2d185b2551a87e |
| institution | Directory Open Access Journal |
| issn | 2324-2426 |
| language | English |
| last_indexed | 2024-03-12T05:45:59Z |
| publishDate | 2021-03-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Neurorestoratology |
| spelling | doaj.art-d77c7053327c4eebbf2d185b2551a87e2023-09-03T05:38:16ZengElsevierJournal of Neurorestoratology2324-24262021-03-0191728010.26599/JNR.2021.9040004Behavioural multigenerational effects induced by the administration of very low doses of zinc during pregnancy, lactation, and prepuberal period in the ratSilvia G. Ratti0Osvaldo J. Sacchi1Edgardo O. Alvarez2<institution>Laboratorio de Epigénesis y Neuropsicofarmacología Experimental, Facultad de Ciencias Médicas, Facultad de Ciencias Veterinarias, Universidad Católica de Cuyo, sede San Luis</institution>, <city>San Luis</city>, <country>Argentina</country><institution>Laboratorio de Epigénesis y Neuropsicofarmacología Experimental, Facultad de Ciencias Médicas, Facultad de Ciencias Veterinarias, Universidad Católica de Cuyo, sede San Luis</institution>, <city>San Luis</city>, <country>Argentina</country><institution>Laboratorio de Epigénesis y Neuropsicofarmacología Experimental, Facultad de Ciencias Médicas, Facultad de Ciencias Veterinarias, Universidad Católica de Cuyo, sede San Luis</institution>, <city>San Luis</city>, <country>Argentina</country>In studies from this laboratory, the chronic administration of ZnTe during pregnancy, lactation, and prepuberal stages of litter (F1 generation) modified the behavioral patterns of motivated exploration, lateralized exploration, social activity, and survival responses of maturing rats. To determine whether these affected behaviors would extend to the next generation, F1 litter rats previously exposed to tellurium (Te) up to 30-day-old were left at rest with no further treatment up to 90-day-old. Then, F1 female rats were mated with normal untreated male rats, and in the next generation (F2), the litter rats at 30-day-old preserved the modified behaviors previously observed in their parents. The study revealed that Te effects were intergenerational. Here, considering that ZnTe was used in the previous study and that Zn ion has many physiological functions in the cell, experiments were conducted to elucidate if Zn would have an intergenerational effect similar to Te. Working with the same experimental setup as in the previous study but using ZnCl2 instead of ZnTe, results revealed that none of the behavioral responses studied were affected by the F1 generation. However, in the F2 generation, lateralized exploration and survival behavior were inhibited, suggesting that Zn also has an intergenerational effect.https://www.sciopen.com/article/10.26599/JNR.2021.9040004lateralityzinctrace elementtransgenerational effects |
| spellingShingle | Silvia G. Ratti Osvaldo J. Sacchi Edgardo O. Alvarez Behavioural multigenerational effects induced by the administration of very low doses of zinc during pregnancy, lactation, and prepuberal period in the rat Journal of Neurorestoratology laterality zinc trace element transgenerational effects |
| title | Behavioural multigenerational effects induced by the administration of very low doses of zinc during pregnancy, lactation, and prepuberal period in the rat |
| title_full | Behavioural multigenerational effects induced by the administration of very low doses of zinc during pregnancy, lactation, and prepuberal period in the rat |
| title_fullStr | Behavioural multigenerational effects induced by the administration of very low doses of zinc during pregnancy, lactation, and prepuberal period in the rat |
| title_full_unstemmed | Behavioural multigenerational effects induced by the administration of very low doses of zinc during pregnancy, lactation, and prepuberal period in the rat |
| title_short | Behavioural multigenerational effects induced by the administration of very low doses of zinc during pregnancy, lactation, and prepuberal period in the rat |
| title_sort | behavioural multigenerational effects induced by the administration of very low doses of zinc during pregnancy lactation and prepuberal period in the rat |
| topic | laterality zinc trace element transgenerational effects |
| url | https://www.sciopen.com/article/10.26599/JNR.2021.9040004 |
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