Runx1+ vascular smooth muscle cells are essential for hematopoietic stem and progenitor cell development in vivo

Runx1+ vascular smooth muscle cells are essential for hematopoietic stem and progenitor cell development in vivo

Abstract Hematopoietic stem cells (HSCs) produce all essential cellular components of the blood. Stromal cell lines supporting HSCs follow a vascular smooth muscle cell (vSMC) differentiation pathway, suggesting that some hematopoiesis-supporting cells originate from vSMC precursors. These pericyte-...

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Bibliographic Details
Main Authors: Zaniah N. Gonzalez Galofre, Alastair M. Kilpatrick, Madalena Marques, Diana Sá da Bandeira, Telma Ventura, Mario Gomez Salazar, Léa Bouilleau, Yvan Marc, Ana B. Barbosa, Fiona Rossi, Mariana Beltran, Harmen J. G. van de Werken, Wilfred F. J. van IJcken, Neil C. Henderson, Stuart J. Forbes, Mihaela Crisan
Format: Article
Language:English
Published: Nature Portfolio 2024-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-44913-z

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